Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 201081

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HXB2 Location	Gag(163-180) p24(31-48) DNA(1276..1329)	Gag Epitope Map
Author Location	p24(31-48)
Epitope	AFSPEVIPMFSALSEGAT	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Netherlands
Experimental methods	Cytokine production
Keywords

Notes

• The relationship between CTL escape and the subsequent increase in viral load and CD4 Th responses was studied in 2 patients. In both patients T-cell reactivity and recognition were lost after CTL escape, and in 1 patient only the loss of CTL responses was paralleled by a decrease in IL-2 CD4 Th responses.
• Autologous sequences corresponding to known and predicted Th epitopes were analyzed. AFSPEVIPMFSALSEGAT had fixation of 2 mutations (AF[s/n]PEVIPMF[s/t]ALSEGAT) in 1 of the patients.

References

Geels2006 Mark J. Geels, Christine A. Jansen, Elly Baan, Iris M. De Cuyper, Gijs J. M. van Schijndel, Hanneke Schuitemaker, Jaap Goudsmit, Georgios Pollakis, Frank Miedema, William A. Paxton, and Debbie van Baarle. CTL Escape and Increased Viremia Irrespective of HIV-Specific CD4+ T-Helper Responses in Two HIV-Infected Individuals. Virology, 345(1):209-219, 5 Feb 2006. PubMed ID: 16246391. Show all entries for this paper.