Search T Helper/CD4+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 201101

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HXB2 Location	Gag(157-171) p24(25-39) DNA(1258..1302)	Gag Epitope Map
Author Location
Epitope	KVVEEKAFSPEVIPM	Epitope Alignment
Epitope Name	G040
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201102

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HXB2 Location	Gag(217-231) p24(85-99) DNA(1438..1482)	Gag Epitope Map
Author Location
Epitope	PVHGPIAPGQMREP	Epitope Alignment
Epitope Name	G055
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201100

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HXB2 Location	Gag(225-239) p24(93-107) DNA(1462..1506)	Gag Epitope Map
Author Location
Epitope	PGQMREPRGSDIAGT	Epitope Alignment
Epitope Name	G057
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201106

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HXB2 Location	Gag(241-255) p24(109-123) DNA(1510..1554)	Gag Epitope Map
Author Location
Epitope	STLQEQIGWMTNNPP	Epitope Alignment
Epitope Name	G061
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201093

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HXB2 Location	Gag(257-271) p24(125-139) DNA(1558..1602)	Gag Epitope Map
Author Location
Epitope	PVGEIYKRWIILGLN	Epitope Alignment
Epitope Name	G065
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201091

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HXB2 Location	Gag(265-279) p24(133-147) DNA(1582..1626)	Gag Epitope Map
Author Location
Epitope	WIILGLNKIVRMYSP	Epitope Alignment
Epitope Name	G067
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201099

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HXB2 Location	Gag(285-299) p24(153-167) DNA(1642..1686)	Gag Epitope Map
Author Location
Epitope	IRQGPKEPFRDYVDR	Epitope Alignment
Epitope Name	G072
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201092

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HXB2 Location	Gag(301-315) p24(169-183) DNA(1690..1734)	Gag Epitope Map
Author Location
Epitope	YKTLRAEQASQEVKN	Epitope Alignment
Epitope Name	G076
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201096

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HXB2 Location	Nef(37-51) DNA(8905..8949)	Nef Epitope Map
Author Location
Epitope	LEKHGAITSSNTAAT	Epitope Alignment
Epitope Name	N010
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201097

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HXB2 Location	Nef(37-51) DNA(8905..8949)	Nef Epitope Map
Author Location
Epitope	LEKHGAITSSNTAAT	Epitope Alignment
Epitope Name	N010
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201098

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HXB2 Location	Nef(45-59) DNA(8929..8973)	Nef Epitope Map
Author Location
Epitope	SSNTAATNAACAWLE	Epitope Alignment
Epitope Name	N012
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201104

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HXB2 Location	Nef(65-79) DNA(8989..9033)	Nef Epitope Map
Author Location
Epitope	EVGFPVIPQVPLRPM	Epitope Alignment
Epitope Name	N017
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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Displaying record number 201103

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HXB2 Location	Nef(189-203) DNA(9361..9405)	Nef Epitope Map
Author Location
Epitope	LAFHHVARELHPEYF	Epitope Alignment
Epitope Name	N048
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.

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