Search T Helper/CD4+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 200871

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HXB2 Location	Nef(14-22) DNA(8836..8862)	Nef Epitope Map
Author Location	Nef(14-22 SF2)
Epitope	SAIRERMRR	Epitope Alignment
Epitope Name	95.12, 33.6
Subtype	B
Species (MHC/HLA)	human(DRw6)
Immunogen	in vitro stimulation or selection
Patient MHC/HLA	DP4, DQw1, DQw6, DRw15(2), DRw52, DRw6
Experimental methods	Proliferation
Keywords	epitope processing

Notes

• Seven CD4+ T-cell clones that proliferated in responses to SF2 Nef were generated in vitro by stimulation of PBMC from uninfected donors. These CD4+ clones also had cytotoxic activity.
• These seven clones were capable as of presenting their epitopes to themselves, if Nef peptides were provided.
• The two clones that recognized the epitope SAIRERMRR could also auto-present Nef protein, suggesting that they recognized this epitope in the context of the intact, unprocessed protein.

References

Wentworth1994 P. A. Wentworth and K. S. Steimer. Characterization of Human CD4+, HIV-SF2 Nef-Specific T-Cell Clones for Antigen-Processing and Presentation Requirements and for Cytotoxic Activity. Vaccine, 12(10):885-894, Aug 1994. PubMed ID: 7975829. Show all entries for this paper.

Displaying record number 200872

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HXB2 Location	Nef(43-49) DNA(8923..8943)	Nef Epitope Map
Author Location	Nef(47-53 SF2)
Epitope	ITSSNTA	Epitope Alignment
Epitope Name	1.13
Subtype	B
Species (MHC/HLA)	human(DQw7)
Immunogen	in vitro stimulation or selection
Patient MHC/HLA	DP4, DQw1, DQw7, DR1, DR8, DRw52
Experimental methods	Proliferation
Keywords	epitope processing

Notes

• Seven CD4+ T-cell clones that proliferated in responses to SF2 Nef were generated in vitro by stimulation of PBMC from uninfected donors. These CD4+ clones also had cytotoxic activity.
• These seven clones were capable as of presenting their epitopes to themselves, if Nef peptides were provided.

References

Wentworth1994 P. A. Wentworth and K. S. Steimer. Characterization of Human CD4+, HIV-SF2 Nef-Specific T-Cell Clones for Antigen-Processing and Presentation Requirements and for Cytotoxic Activity. Vaccine, 12(10):885-894, Aug 1994. PubMed ID: 7975829. Show all entries for this paper.

Displaying record number 200870

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HXB2 Location	Nef(64-73) DNA(8986..9015)	Nef Epitope Map
Author Location	Nef(68-77 SF2)
Epitope	EEVGFPVRPQ	Epitope Alignment
Epitope Name	59.25
Subtype	B
Species (MHC/HLA)	human(DRB1*15:01)
Immunogen	in vitro stimulation or selection
Patient MHC/HLA	DP4, DQw1, DR1, DRw15(2)
Experimental methods	Proliferation
Keywords	epitope processing

Notes

• Seven CD4+ T-cell clones that proliferated in responses to SF2 Nef were generated in vitro by stimulation of PBMC from uninfected donors. These CD4+ clones also had cytotoxic activity.
• These seven clones were capable as of presenting their epitopes to themselves, if Nef peptides were provided.
• Database note: author-assigned restricting HLA DRw15(2) was reassigned to DRB1*1501, based on updated nomenclature, Bodmer1999 [PMID 10363728].

References

Wentworth1994 P. A. Wentworth and K. S. Steimer. Characterization of Human CD4+, HIV-SF2 Nef-Specific T-Cell Clones for Antigen-Processing and Presentation Requirements and for Cytotoxic Activity. Vaccine, 12(10):885-894, Aug 1994. PubMed ID: 7975829. Show all entries for this paper.

Displaying record number 200875

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HXB2 Location	Nef(66-73) DNA(8992..9015)	Nef Epitope Map
Author Location	Nef(70-77 SF2)
Epitope	VGFPVRPQ	Epitope Alignment
Epitope Name	29.16
Subtype	B
Species (MHC/HLA)	human(DRB1*01, DRB1*15:01)
Immunogen	in vitro stimulation or selection
Patient MHC/HLA	DP4, DQw1, DR1, DRw15(2)
Experimental methods	Proliferation
Keywords	epitope processing

Notes

• Seven CD4+ T-cell clones that proliferated in responses to SF2 Nef were generated in vitro by stimulation of PBMC from uninfected donors. These CD4+ clones also had cytotoxic activity.
• These seven clones were capable as of presenting their epitopes to themselves, if Nef peptides were provided.
• Database note: author-assigned restricting HLA DRw15(2) was reassigned to DRB1*1501; author-assigned restricting HLA DR1 was reassigned to DRB1*01, based on updated nomenclature, Bodmer1999 [PMID 10363728].

References

Wentworth1994 P. A. Wentworth and K. S. Steimer. Characterization of Human CD4+, HIV-SF2 Nef-Specific T-Cell Clones for Antigen-Processing and Presentation Requirements and for Cytotoxic Activity. Vaccine, 12(10):885-894, Aug 1994. PubMed ID: 7975829. Show all entries for this paper.

Displaying record number 200874

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HXB2 Location	Nef(181-188) DNA(9337..9360)	Nef Epitope Map
Author Location	Nef(185-192 SF2)
Epitope	LVWRFDSK	Epitope Alignment
Epitope Name	6.38
Subtype	B
Species (MHC/HLA)	human(DP5)
Immunogen	in vitro stimulation or selection
Patient MHC/HLA	DP5, DQw7, DRw11, DRw52
Experimental methods	Proliferation
Keywords	epitope processing

Notes

• Seven CD4+ T-cell clones that proliferated in responses to SF2 Nef were generated in vitro by stimulation of PBMC from uninfected donors. These CD4+ clones also had cytotoxic activity.
• These seven clones were capable as of presenting their epitopes to themselves, if Nef peptides were provided.

References

Wentworth1994 P. A. Wentworth and K. S. Steimer. Characterization of Human CD4+, HIV-SF2 Nef-Specific T-Cell Clones for Antigen-Processing and Presentation Requirements and for Cytotoxic Activity. Vaccine, 12(10):885-894, Aug 1994. PubMed ID: 7975829. Show all entries for this paper.

Displaying record number 200873

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HXB2 Location	Nef(191-199) DNA(9367..9393)	Nef Epitope Map
Author Location	Nef(195-203 SF2)
Epitope	FHHMARELH	Epitope Alignment
Epitope Name	3.2
Subtype	B
Species (MHC/HLA)	human(DRB1*01)
Immunogen	in vitro stimulation or selection
Patient MHC/HLA	DP4, DQw1, DQw7, DR1, DR8, DRw52
Experimental methods	Proliferation
Keywords	epitope processing

Notes

• Seven CD4+ T-cell clones that proliferated in responses to SF2 Nef were generated in vitro by stimulation of PBMC from uninfected donors. These CD4+ clones also had cytotoxic activity.
• These seven clones were capable as of presenting their epitopes to themselves, if Nef peptides were provided.
• Database note: author-assigned restricting HLA DR1 was reassigned to DRB1*01, based on updated nomenclature, Bodmer1999 [PMID 10363728].

References

Wentworth1994 P. A. Wentworth and K. S. Steimer. Characterization of Human CD4+, HIV-SF2 Nef-Specific T-Cell Clones for Antigen-Processing and Presentation Requirements and for Cytotoxic Activity. Vaccine, 12(10):885-894, Aug 1994. PubMed ID: 7975829. Show all entries for this paper.