Search T Helper/CD4+ T-Cell Epitope Database

Found 12 matching records:

Displaying record number 201427

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HXB2 Location	Gag(139-153) p24(7-21) DNA(1204..1248)	Gag Epitope Map
Author Location	Gag(171-)
Epitope	QGQMVHQAISPRTLN	Epitope Alignment
Epitope Name	Gag171
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201428

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HXB2 Location	Gag(259-273) p24(127-141) DNA(1564..1608)	Gag Epitope Map
Author Location	Gag(294-)
Epitope	GEIYKRWIILGLNKI	Epitope Alignment
Epitope Name	Gag294
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201429

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HXB2 Location	Gag(263-277) p24(131-145) DNA(1576..1620)	Gag Epitope Map
Author Location	Gag(298-)
Epitope	KRWIILGLNKIVRMY	Epitope Alignment
Epitope Name	Gag298
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201430

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HXB2 Location	Pol(279-293) RT(124-138) DNA(2919..2963)	Pol Epitope Map
Author Location	Pol(303-)
Epitope	FRKYTAFTIPSINNE	Epitope Alignment
Epitope Name	Pol303
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201431

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HXB2 Location	Pol(311-325) RT(156-170) DNA(3015..3059)	Pol Epitope Map
Author Location	Pol(335-)
Epitope	SPAIFQSSMTKILEP	Epitope Alignment
Epitope Name	Pol335
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201436

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HXB2 Location	Pol(592-606) RT(437-451) DNA(3858..3902)	Pol Epitope Map
Author Location	Pol(619-)
Epitope	AETFYVDGAANRETK	Epitope Alignment
Epitope Name	Pol619
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201432

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HXB2 Location	Pol(684-698) RT(529-543) DNA(4134..4178)	Pol Epitope Map
Author Location	Pol(711-)
Epitope	EKVYLAWVPAHKGIG	Epitope Alignment
Epitope Name	Pol711
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201433

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HXB2 Location	Pol(685-699) RT(530-544) DNA(4137..4181)	Pol Epitope Map
Author Location	Pol(712-)
Epitope	KVYLAWVPAHKGIGG	Epitope Alignment
Epitope Name	Pol712
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201434

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HXB2 Location	Pol(888-902) Integrase(173-187) DNA(4746..4790)	Pol Epitope Map
Author Location	Pol(915-)
Epitope	KTAVQMAVFIHNFKR	Epitope Alignment
Epitope Name	Pol915
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201435

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HXB2 Location	Pol(929-943) Integrase(214-228) DNA(4869..4913)	Pol Epitope Map
Author Location	Pol(956-)
Epitope	QKQITKIQNFRVYYR	Epitope Alignment
Epitope Name	Pol956
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201437

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HXB2 Location	Vpu(30-44) DNA(6149..6193)	Vpu Epitope Map
Author Location	Vpu(31-)
Epitope	YRKILRQRKIDRLID	Epitope Alignment
Epitope Name	Vpu31
Species (MHC/HLA)	transgenic mouse(DR)
Immunogen	vaccine
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type	polyepitope
Vaccine component	Env, Gag, Pol, Vpu

Notes

• A novel polypeptide vaccine of HIV T helper epitopes (EP-1043) and a DNA vaccine of HIV CTL epitopes was designed and tested for immunogenicity and safety in transgenic mice, rabbits and guinea pigs.
• A Phase I human trial is described in Jin2009.
• This peptide was immunogenic in H2bxd mice.

References

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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Displaying record number 201618

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HXB2 Location	HIV-1	HIV-1 Epitope Map
Author Location
Epitope
Subtype	B, multiple
Species (MHC/HLA)	human(DR1, DR4, DR7)
Immunogen	vaccine
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords	vaccine-induced immune responses

Vaccine Details

Vaccine type	DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain	B clade, multiple epitope immunogen, other

Notes

• Two HIV-1 vaccines, a DNA plasmid-vector (EP-1233) and a recombinant modified vaccinia virus Ankara vaccine (MVA-mBN32), both encoding 21 CTL and 18 HTL epitopes were evaluated in 36 uninfected adults. EP-1233 encoded the polyepitopes under one promoter while mBN32 encoded them under different promoters. Both vaccines were found to be safe but were ineffective at inducing strong, specific immune responses.
• The helper T-cell epitopes (HTL) are listed in previous entries, Walker2009, and they are discussed in Jin2009. Only 1/36 subjects showed any CD4+ T-cell response or potential for response.

References

Gorse2012 Geoffrey J. Gorse, Mark J. Newman, Allan deCamp, Christine Mhorag Hay, Stephen C. De Rosa, Elizabeth Noonan, Brian D. Livingston, Jonathan D. Fuchs, Spyros A. Kalams, Farah L. Cassis-Ghavami, and NIAID HIV Vaccine Trials Network. DNA and Modified Vaccinia Virus Ankara Vaccines Encoding Multiple Cytotoxic and Helper T-Lymphocyte Epitopes of Human Immunodeficiency Virus Type 1 (HIV-1) Are Safe but Weakly Immunogenic in HIV-1-Uninfected, Vaccinia Virus-Naive Adults. Clin. Vaccine Immunol., 19(5):649-658, May 2012. PubMed ID: 22398243. Show all entries for this paper.

Jin2009 Xia Jin, Mark J Newman, Stephen De-Rosa, Cristine Cooper, Evan Thomas, Michael Keefer, Jonathan Fuchs, William Blattner, Brian D. Livingston, Denise M. McKinney, Elizabeth Noonan, Allan deCamp, Olivier D. Defawe, Margaret Wecker, and NIAID HIV Vaccine Trials Network. A Novel HIV T Helper Epitope-Based Vaccine Elicits Cytokine-Secreting HIV-Specific CD4+ T Cells in a Phase I Clinical Trial in HIV-Uninfected Adults. Vaccine, 27(50):7080-7086, 23 Nov 2009. PubMed ID: 19786145. Show all entries for this paper.

Walker2009 Leslie E. Walker, Lo Vang, Xuefei Shen, Brian D. Livingston, Penny Post, Alessandro Sette, C. Steven Godin, and Mark J. Newman. Design and Preclinical Development of a Recombinant Protein and DNA Plasmid Mixed Format Vaccine to Deliver HIV-Derived T-Lymphocyte Epitopes. Vaccine, 27(50):7087-7095, 23 Nov 2009. PubMed ID: 19786132. Show all entries for this paper.

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