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HIV Molecular Immunology Database

Search T Helper/CD4+ T-Cell Epitope Database

Found 9 matching records:

Displaying record number 127

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HXB2 Location Env(32-44)
gp120(32-44)
DNA(6318..6356)
Env Epitope Map
Author Location gp120(39-51)
Epitope EQLWVTVYYGVPV Epitope Alignment
EQLWVTVYYGVPV epitope logo
Species (MHC/HLA) mouse(H-2bxk)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 128

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HXB2 Location Env(38-48)
gp120(38-48)
DNA(6336..6368)
Env Epitope Map
Author Location gp120(45-55)
Epitope VYYGVPVWKEA Epitope Alignment
VYYGVPVWKEA epitope logo
Species (MHC/HLA) mouse(H-2bxk, H-2sxd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 131

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HXB2 Location Env(41-54)
gp120(41-54)
DNA(6345..6386)
Env Epitope Map
Author Location gp120(48-61)
Epitope GVPVWKEATTLFC Epitope Alignment
GVPVWKEATTLFC epitope logo
Species (MHC/HLA) mouse(H-2sxd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 133

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HXB2 Location Env(65-75)
gp120(65-75)
DNA(6417..6449)
Env Epitope Map
Author Location gp120(72-82)
Epitope AHKVWATHACV Epitope Alignment
AHKVWATHACV epitope logo
Species (MHC/HLA) mouse(H-2bxk, H-2sxd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 135

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HXB2 Location Env(74-85)
gp120(74-85)
DNA(6444..6479)
Env Epitope Map
Author Location gp120(81-92)
Epitope CVPTNPVPQEVV Epitope Alignment
CVPTNPVPQEVV epitope logo
Species (MHC/HLA) mouse(H-2bxk, H-2sxd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 138

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HXB2 Location Env(102-114)
gp120(102-114)
DNA(6528..6566)
Env Epitope Map
Author Location gp120(109-121)
Epitope EQMHEDIISLWDQ Epitope Alignment
EQMHEDIISLWDQ epitope logo
Species (MHC/HLA) mouse(H-2bxk)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 164

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HXB2 Location Env(199-211)
gp120(199-211)
DNA(6819..6857)
Env Epitope Map
Author Location gp120(204-216)
Epitope SVITQACSKVSFE Epitope Alignment
SVITQACSKVSFE epitope logo
Species (MHC/HLA) mouse(H-2bxk, H-2sxd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 169

Download this epitope record as JSON.

HXB2 Location Env(210-223)
gp120(210-223)
DNA(6852..6893)
Env Epitope Map
Author Location gp120(215-228)
Epitope FEPIPIHYCAFPGF Epitope Alignment
FEPIPIHYCAFPGF epitope logo
Species (MHC/HLA) mouse(H-2bxk)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


Displaying record number 292

Download this epitope record as JSON.

HXB2 Location Env(519-543)
gp41(8-32)
DNA(7779..7853)
Env Epitope Map
Author Location gp41(519-543)
Epitope FLGFLGAAGSTMGAASLTLTVQARC Epitope Alignment
Species (MHC/HLA) mouse(H-2bxk, H-2sxd)
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type peptide

Notes

References

Sastry1991 K. J. Sastry and R. B. Arlinghaus. Identification of T-Cell Epitopes without B-Cell Activity in the First and Second Conserved Regions of the HIV Env Protein. AIDS, 5:699-707, 1991. Notes: Seven out of 19 peptides induced good T-cell proliferative response in mice representing four major histocompatibility complex haplotypes, without eliciting an Ab response. Eleven peptides were able to induce T-cells that could proliferate in response to recombinant gp160 (greater than or equal to 3 fold relative to unrelated peptides). Peptides were modified to generate polymers with disulfide bonds or micelles with palmitic acid residues attached to the amino-terminal lysine; in these configurations peptides were immunogenic without being coupled to a carrier molecule. F1 hybrid mice were used: ASW x BALBc F1 (H-2$^kxb$) and B6C3 F1 (H-2$^sxd$). PubMed ID: 1715718. Show all entries for this paper.


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