Search T Helper/CD4+ T-Cell Epitope Database

Found 42 matching records:

Displaying record number 201742

Download this epitope record as JSON.

HXB2 Location	Gag(9-26) p17(9-26) DNA(814..867)	Gag Epitope Map
Author Location	Gag
Epitope	SGGELDRWEKIRLRPGGK	Epitope Alignment
Epitope Name	OLP-2
Species (MHC/HLA)	human(DRB1*07:01, DRB1*11:01, DRB1*13:01, DRB1*13:02, DRB3*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-2 (OLP-2), SGGELDRWEKIRLRPGGK, was promiscuous as it was restricted by 5 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201716

Download this epitope record as JSON.

HXB2 Location	Gag(25-41) p17(25-41) DNA(862..912)	Gag Epitope Map
Author Location	Gag
Epitope	GKKKYKLKHIVWASREL	Epitope Alignment
Epitope Name	OLP-4
Species (MHC/HLA)	human(DRB1*01:01, DRB1*07:01, DRB1*08:01, DRB1*11:01, DRB1*13:02, DRB1*13:03, DRB3*01:01, DRB3*03:01, DRB4*01:01, DRB5*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Immunodominant overlapping peptide-4 (OLP-4), GKKKYKLKHIVWASREL, was promiscuous as it was restricted by 10 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.
• OLP-4 promiscuity was evident in that it could bind 13 different HLA-DRB1 in HLA-binding competition assays. IC₅₀ values for each peptide-DBR1 interaction were *0101 (33 nM), *0301 (915 nM), *0401 (82 nM), *0405 (119 nM), *0701 (42 nM), *0802 (14 nM), *0901 (105 nM), *1001 (28 nM), *1101 (52 nM), *1201 (450 nM), *1302 (739 nM), *1501 (78 nM) and *1602 (84 nM).

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201741

Download this epitope record as JSON.

HXB2 Location	Gag(32-46) p17(32-46) DNA(883..927)	Gag Epitope Map
Author Location	Gag
Epitope	KHIVWASRELERFAV	Epitope Alignment
Epitope Name	OLP-5
Species (MHC/HLA)	human(DRB1*03:01, DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB3*01:01, DRB5*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-5 (OLP-5), KHIVWASRELERFAV, was promiscuous as it was restricted by 6 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201750

Download this epitope record as JSON.

HXB2 Location	Gag(37-51) p17(37-51) DNA(898..942)	Gag Epitope Map
Author Location	Gag
Epitope	ASRELERFAVNPGLL	Epitope Alignment
Epitope Name	OLP-6
Species (MHC/HLA)	human(DRB1*13:01, DRB1*13:02, DRB4*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-6 (OLP-6), ASRELERFAVNPGLL, was promiscuous as it was restricted by 3 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201745

Download this epitope record as JSON.

HXB2 Location	Gag(42-58) p17(42-58) DNA(913..963)	Gag Epitope Map
Author Location	Gag
Epitope	ERFAVNPGLLETSEGCR	Epitope Alignment
Epitope Name	OLP-7
Species (MHC/HLA)	human(DRB1*13:02, DRB1*13:03, DRB1*15:01, DRB3*03:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-7 (OLP-7), ERFAVNPGLLETSEGCR, was promiscuous as it was restricted by 4 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201755

Download this epitope record as JSON.

HXB2 Location	Gag(70-86) p17(70-86) DNA(997..1047)	Gag Epitope Map
Author Location	Gag
Epitope	TGSEELRSLYNTVATLY	Epitope Alignment
Epitope Name	OLP-11
Species (MHC/HLA)	human(DRB1*04:05, DRB1*07:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-11 (OLP-11), TGSEELRSLYNTVATLY, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201756

Download this epitope record as JSON.

HXB2 Location	Gag(77-94) p17(77-94) DNA(1018..1071)	Gag Epitope Map
Author Location	Gag
Epitope	SLYNTVATLYCVHQRIEV	Epitope Alignment
Epitope Name	OLP-12
Species (MHC/HLA)	human(DRB1*07:01, DRB1*14:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-12 (OLP-12), SLYNTVATLYCVHQRIEV, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201765

Download this epitope record as JSON.

HXB2 Location	Gag(134-150) p24(2-18) DNA(1189..1239)	Gag Epitope Map
Author Location	Gag
Epitope	IVQNLQGQMVHQAISPR	Epitope Alignment
Epitope Name	OLP-19
Species (MHC/HLA)	human(DRB1*09:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-19 (OLP-19), IVQNLQGQMVHQAISPR, was restricted by 1 HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201757

Download this epitope record as JSON.

HXB2 Location	Gag(149-164) p24(17-32) DNA(1234..1281)	Gag Epitope Map
Author Location	Gag
Epitope	PRTLNAWVKVVEEKAF	Epitope Alignment
Epitope Name	OLP-21
Species (MHC/HLA)	human(DRB1*13:01, DRB1*13:04)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-21 (OLP-21), PRTLNAWVKVVEEKAF, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201767

Download this epitope record as JSON.

HXB2 Location	Gag(155-172) p24(23-40) DNA(1252..1305)	Gag Epitope Map
Author Location	Gag
Epitope	WVKVVEEKAFSPEVIPMF	Epitope Alignment
Epitope Name	OLP-22
Species (MHC/HLA)	human(DRB1*11:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-22 (OLP-22), WVKVVEEKAFSPEVIPMF, was restricted by 1 HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201746

Download this epitope record as JSON.

HXB2 Location	Gag(163-179) p24(31-47) DNA(1276..1326)	Gag Epitope Map
Author Location	Gag
Epitope	AFSPEVIPMFSALSEGA	Epitope Alignment
Epitope Name	OLP-23
Species (MHC/HLA)	human(DRB1*04:01, DRB1*07:01, DRB1*15:01, DRB4*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-23 (OLP-23), AFSPEVIPMFSALSEGA, was promiscuous as it was restricted by 4 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201766

Download this epitope record as JSON.

HXB2 Location	Gag(209-224) p24(77-92) DNA(1414..1461)	Gag Epitope Map
Author Location	Gag
Epitope	AAEWDRLHPVHAGPIA	Epitope Alignment
Epitope Name	OLP-29
Species (MHC/HLA)	human(DRB1*07:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-29 (OLP-29), AAEWDRLHPVHAGPIA, was restricted by 1 HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201768

Download this epitope record as JSON.

HXB2 Location	Gag(215-232) p24(83-100) DNA(1432..1485)	Gag Epitope Map
Author Location	Gag
Epitope	LHPVHAGPIAPGQMREPR	Epitope Alignment
Epitope Name	OLP-30
Species (MHC/HLA)	human(DRB1*11:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-30 (OLP-30), LHPVHAGPIAPGQMREPR, was restricted by 1 HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201758

Download this epitope record as JSON.

HXB2 Location	Gag(234-250) p24(102-118) DNA(1489..1539)	Gag Epitope Map
Author Location	Gag
Epitope	SDIAGTTSTLQEQIGWM	Epitope Alignment
Epitope Name	OLP-33
Species (MHC/HLA)	human(DRB1*04:04, DRB1*15:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-33 (OLP-33), SDIAGTTSTLQEQIGWM, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201747

Download this epitope record as JSON.

HXB2 Location	Gag(241-258) p24(109-126) DNA(1510..1563)	Gag Epitope Map
Author Location	Gag
Epitope	STLQEQIGWMTNNPPIPV	Epitope Alignment
Epitope Name	OLP-34
Species (MHC/HLA)	human(DRB1*01:01, DRB1*13:03, DRB3*01:01, DRB3*03:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-34 (OLP-34), STLQEQIGWMTNNPPIPV, was promiscuous as it was restricted by 4 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201759

Download this epitope record as JSON.

HXB2 Location	Gag(249-266) p24(117-134) DNA(1534..1587)	Gag Epitope Map
Author Location	Gag
Epitope	WMTNNPPIPVGEIYKRWI	Epitope Alignment
Epitope Name	OLP-35
Species (MHC/HLA)	human(DRB3*01:01, DRB3*03:03)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-35 (OLP-35), WMTNNPPIPVGEIYKRWI, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201743

Download this epitope record as JSON.

HXB2 Location	Gag(265-282) p24(133-150) DNA(1582..1635)	Gag Epitope Map
Author Location	Gag
Epitope	WIILGLNKIVRMYSPTSI	Epitope Alignment
Epitope Name	OLP-37
Species (MHC/HLA)	human(DRB1*03:02, DRB1*11:01, DRB1*13:01, DRB1*15:01, DRB1*15:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-37 (OLP-37), WIILGLNKIVRMYSPTSI, was promiscuous as it was restricted by 5 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201769

Download this epitope record as JSON.

HXB2 Location	Gag(288-305) p24(156-173) DNA(1651..1704)	Gag Epitope Map
Author Location	Gag
Epitope	GPKEPFRDYVDRFYKTLR	Epitope Alignment
Epitope Name	OLP-40
Species (MHC/HLA)	human(DRB1*13:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-40 (OLP-40), GPKEPFRDYVDRFYKTLR, was restricted by 1 HLA-DR, DRBI*1301 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201715

Download this epitope record as JSON.

HXB2 Location	Gag(296-313) p24(164-181) DNA(1675..1728)	Gag Epitope Map
Author Location	Gag
Epitope	YVDRFYKTLRAEQASQEV	Epitope Alignment
Epitope Name	OLP-41
Species (MHC/HLA)	human(DRB1*04:01, DRB1*07:01, DRB1*08:01, DRB1*10:01, DRB1*11:01, DRB1*13:01, DRB1*13:02, DRB1*13:03, DRB1*15:01, DRB1*15:02, DRB4*01:01, DRB5*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation, optimal epitope

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Immunodominant overlapping peptide-41 (OLP-41), YVDRFYKTLRAEQASQEV, was the most frequently targeted of all peptides by HLA-Class II-restricted helper T cells as studied by IFN-γ EliSpot. It was promiscuous as it was restricted by 12 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.
• OLP-41 promiscuity was evident in that it could bind 12 different HLA-DRB1 in HLA-binding competition assays. IC₅₀ values for each peptide-DBR1 interaction were *0101 (6 nM), *0301 (91 nM), *0401 (9 nM), *0405 (75 nM), *0701 (375 nM), *0802 (8 nM), *0901 (40 nM), *1001 (2 nM), *1101 (77 nM), *1302 (404 nM), *1501 (342 nM) and *1602 (4 nM).
• Optimal epitope to DRB1*0401 was DRFYKTLRAEQASQEV as determined by IFN-γ EliSpot. Minimal stimulatory epitopes were FQ12, FYFYKTLRAEQASQ or FS11, FYFYKTLRAEQAS.
• Optimal epitope to DRB1*0701 was DRFYKTLRAEQASQEV as determined by IFN-γ EliSpot. Minimal stimulatory epitopes were RA11, RFYKTLRAEQA or RQ10, RFYKTLRAEQ.
• Optimal epitope to DRB1*1101 was RFYKTLRAEQASQEV as determined by IFN-γ EliSpot. Minimal stimulatory epitopes were FA10, FYKTLRAEQA or FQ9, FYKTLRAEQ.
• Optimal epitopes to DRB1*1301 and DRB1*1302 were YVDRFYKTLRAE and YVDRFYKTLRAEQASQ respectively as determined by IFN-γ EliSpot. Minimal stimulatory epitopes for both were VE11, VDRFYKTLRAE or YE12, YVDRFYKTLRAE.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201770

Download this epitope record as JSON.

HXB2 Location	Gag(312-326) p24(180-194) DNA(1723..1767)	Gag Epitope Map
Author Location	Gag
Epitope	EVKNWMTETLLVQNA	Epitope Alignment
Epitope Name	OLP-43
Species (MHC/HLA)	human(DRB1*14:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-43 (OLP-43), EVKNWMTETLLVQNA, was restricted by 1 HLA-DR, DRBI*1401 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201771

Download this epitope record as JSON.

HXB2 Location	Gag(340-358) p24(208-226) DNA(1807..1863)	Gag Epitope Map
Author Location	Gag
Epitope	AATLEEMMTACQGVGGPGH	Epitope Alignment
Epitope Name	OLP-47
Species (MHC/HLA)	human(DRB1*04:04)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-47 (OLP-47), AATLEEMMTACQGVGGPGH, was restricted by 1 HLA-DR, DRBI*0404 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201772

Download this epitope record as JSON.

HXB2 Location	Gag(371-388) p2p7p1p6(8-25) DNA(1900..1953)	Gag Epitope Map
Author Location	Gag
Epitope	TNSATIMMQRGNFRNQRK	Epitope Alignment
Epitope Name	OLP-51
Species (MHC/HLA)	human(DRB1*15:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-51 (OLP-51), TNSATIMMQRGNFRNQRK, was restricted by 1 HLA-DR, DRBI*1502 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201763

Download this epitope record as JSON.

HXB2 Location	Gag(392-409) p2p7p1p6(29-46) DNA(1963..2016)	Gag Epitope Map
Author Location	Gag
Epitope	CFNCGKEGHIAKNCRAPR	Epitope Alignment
Epitope Name	OLP-54
Species (MHC/HLA)	human(DRB1*09:01, DRB1*13:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-54 (OLP-54), CFNCGKEGHIAKNCRAPR, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201764

Download this epitope record as JSON.

HXB2 Location	Gag(400-415) p2p7p1p6(37-52) DNA(1987..2034)	Gag Epitope Map
Author Location	Gag
Epitope	HIAKNCRAPRKKGCWK	Epitope Alignment
Epitope Name	OLP-55
Species (MHC/HLA)	human(DRB1*07:01, DRB1*13:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-55 (OLP-55), HIAKNCRAPRKKGCWK, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201773

Download this epitope record as JSON.

HXB2 Location	Gag(406-423) p2p7p1p6(43-60) DNA(2005..2058)	Gag Epitope Map
Author Location	Gag
Epitope	RAPRKKGCWKCGKEGHQM	Epitope Alignment
Epitope Name	OLP-56
Species (MHC/HLA)	human(DRB1*09:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-56 (OLP-56), RAPRKKGCWKCGKEGHQM, was restricted by 1 HLA-DR, DRBI*0901 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201751

Download this epitope record as JSON.

HXB2 Location	Gag(429-444) p2p7p1p6(66-81) DNA(2074..2121)	Gag Epitope Map
Author Location	Gag
Epitope	RQANFLGKIWPSHKGR	Epitope Alignment
Epitope Name	OLP-59
Species (MHC/HLA)	human(DRB1*13:01, DRB1*15:01, DRB5*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-59 (OLP-59), RQANFLGKIWPSHKGR, was promiscuous as it was restricted by 3 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201752

Download this epitope record as JSON.

HXB2 Location	Gag(435-452) p2p7p1p6(72-89) DNA(2092..2145)	Gag Epitope Map
Author Location	Gag
Epitope	GKIWPSHKGRPGNFLQSR	Epitope Alignment
Epitope Name	OLP-60
Species (MHC/HLA)	human(DRB1*07:01, DRB1*13:01, DRB1*15:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-60 (OLP-60), GKIWPSHKGRPGNFLQSR, was promiscuous as it was restricted by 3 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201775

Download this epitope record as JSON.

HXB2 Location	Gag(448-465) p2p7p1p6(85-102) DNA(2131..2184)	Gag Epitope Map
Author Location	Gag
Epitope	FLQSRPEPTAPPEESFRF	Epitope Alignment
Epitope Name	OLP-62
Species (MHC/HLA)	human(DRB1*07:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-62 (OLP-62), FLQSRPEPTAPPEESFRF, was restricted by 1 HLA-DR, DRBI*0701 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201774

Download this epitope record as JSON.

HXB2 Location	Gag(448-465) p2p7p1p6(85-102) DNA(2131..2184)	Gag Epitope Map
Author Location	Gag
Epitope	FLQSRPEPTAPPEESFRF	Epitope Alignment
Epitope Name	OLP-62
Species (MHC/HLA)	human(DRB1*07:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-62 (OLP-62), FLQSRPEPTAPPEESFRF, was restricted by 1 HLA-DR, DRBI*0701 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201776

Download this epitope record as JSON.

HXB2 Location	Gag(481-500) p2p7p1p6(118-137) DNA(2230..2289)	Gag Epitope Map
Author Location	Gag
Epitope	KELYPLASLRSLFGNDPSSQ	Epitope Alignment
Epitope Name	OLP-66
Species (MHC/HLA)	human(DRB1*15:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-66 (OLP-66), KELYPLASLRSLFGNDPSSQ, was restricted by 1 HLA-DR, DRBI*1502 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201762

Download this epitope record as JSON.

HXB2 Location	Pol(536-553) RT(381-398) DNA(3690..3743)	Pol Epitope Map
Author Location	Pol
Epitope	VIWGKTPKFKLPIQKETW	Epitope Alignment
Epitope Name	OLP-217
Species (MHC/HLA)	human(DRB1*13:01, DRB3*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-217 (OLP-217), PSPEGTRQARRNRRRRW, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201749

Download this epitope record as JSON.

HXB2 Location	Tat(40-57) DNA(5948..6001)	Tat Epitope Map
Author Location	Tat
Epitope	TKGLGISYGRKKRRQRRR	Epitope Alignment
Epitope Name	OLP-116
Species (MHC/HLA)	human(DRB1*13:02, DRB1*13:03, DRB3*01:01, DRB3*03:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-116 (OLP-116), TKGLGISYGRKKRRQRRR, was promiscuous as it was restricted by 4 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201761

Download this epitope record as JSON.

HXB2 Location	Rev(29-45) DNA(8387..8437)	Rev Epitope Map
Author Location	Rev
Epitope	PSPEGTRQARRNRRRRW	Epitope Alignment
Epitope Name	OLP-98
Species (MHC/HLA)	human(DRB1*13:01, DRB3*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-98 (OLP-98), PSPEGTRQARRNRRRRW, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201738

Download this epitope record as JSON.

HXB2 Location	gp160(30-45) gp120(30-45) DNA(6312..6359)	gp160 Epitope Map
Author Location	Gag
Epitope	AAEQLWTVYYGVPPVW	Epitope Alignment
Epitope Name	OLP-293
Species (MHC/HLA)	human(DRB1*11:01, DRB1*15:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Immunodominant overlapping peptide-293 (OLP-293), AAEQLWTVYYGVPPVWK, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.
• OLP-293 promiscuity was evident in that it could bind 8 different HLA-DRB1 in HLA-binding competition assays. IC₅₀ values for each peptide-DBR1 interaction were *0101 (218 nM), *0401 (616 nM), *0405 (179 nM), *0802 (465 nM), *0901 (181 nM), *1001 (210 nM), *1501 (135 nM) and *1602 (12 nM).

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201754

Download this epitope record as JSON.

HXB2 Location	gp160(88-105) gp120(88-105) DNA(6486..6539)	gp160 Epitope Map
Author Location	Env
Epitope	NVTENFNMWKNNMVEQMH	Epitope Alignment
Epitope Name	OLP-301
Species (MHC/HLA)	human(DRB1*11:01, DRB1*15:01, DRB1*15:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-301 (OLP-301), NVTENFNMWKNNMVEQMH, was promiscuous as it was restricted by 3 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201753

Download this epitope record as JSON.

HXB2 Location	gp160(173-191) gp120(173-191) DNA(6741..6797)	gp160 Epitope Map
Author Location	Env
Epitope	YALFYKLDVVPIDNDNTSY	Epitope Alignment
Epitope Name	OLP-312
Species (MHC/HLA)	human(DRB1*01:01, DRB1*07:01, DRB1*10:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-312 (OLP-312), YALFYKLDVVPIDNDNTSY, was promiscuous as it was restricted by 3 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201739

Download this epitope record as JSON.

HXB2 Location	gp160(207-224) gp120(207-224) DNA(6843..6896)	gp160 Epitope Map
Author Location	Env
Epitope	KVSFEPIPIHYCAPAGFA	Epitope Alignment
Epitope Name	OLP-316
Species (MHC/HLA)	human(DRB1*01:01, DRB1*11:01, DRB3*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Immunodominant overlapping peptide-316 (OLP-316), KVSFEPIPIHYCAPAGFA, was promiscuous as it was restricted by 3 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.
• OLP-316 promiscuity was evdient in that it could bind 9 different HLA-DRB1 as seen in HLA-binding competition assays. IC₅₀ values for each peptide-DBR1 interaction were *0101 (77 nM), *0401 (454 nM), *0701 (709 nM), *0901 (393 nM), *1001 (78 nM), *1101 (653 nM), *1201 (75 nM), *1501 (80 nM) and *1602 (236 nM).

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201740

Download this epitope record as JSON.

HXB2 Location	gp160(572-588) gp41(61-77) DNA(7938..7988)	gp160 Epitope Map
Author Location	Env
Epitope	GIKQLQARVLAVERYLK	Epitope Alignment
Epitope Name	OLP-365
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Immunodominant overlapping peptide-365, OLP-365, was promiscuous in that it could bind 13 different HLA-DRB1 in HLA-binding competition assays. IC₅₀ values for each peptide-DBR1 interaction were *0101 (1 nM), *0301 (392 nM), *0401 (559 nM), *0405 (122 nM), *0701 (99 nM), *0802 (474 nM), *0901 (34 nM), *1001 (9 nM), *1101 (67 nM), *1201 (8 nM), *1302 (567 nM), *1501 (52 nM) and *1602 (83 nM).

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201777

Download this epitope record as JSON.

HXB2 Location	Nef(8-23) DNA(8818..8865)	Nef Epitope Map
Author Location	Nef
Epitope	RSVVGWPAVRERMRRA	Epitope Alignment
Epitope Name	OLP-68
Species (MHC/HLA)	human(DRB1*13:02)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-68 (OLP-6), RSVVGWPAVRERMRRA, was restricted by 1 HLA-DR, DRBI*1302 across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201760

Download this epitope record as JSON.

HXB2 Location	Nef(81-97) DNA(9037..9087)	Nef Epitope Map
Author Location	Nef
Epitope	YKAAVDLSHFLKEKGGL	Epitope Alignment
Epitope Name	OLP-78
Species (MHC/HLA)	human(DRB1*07:01, DRB1*08:04)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-78 (OLP-78), YKAAVDLSHFLKEKGGL, was promiscuous as it was restricted by 2 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201744

Download this epitope record as JSON.

HXB2 Location	Nef(112-127) DNA(9130..9177)	Nef Epitope Map
Author Location	Nef
Epitope	LWVYHTQGYFPDWQNY	Epitope Alignment
Epitope Name	OLP-82
Species (MHC/HLA)	human(DRB1*07:01, DRB1*13:01, DRB1*14:01, DRB3*01:01, DRB4*01:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-82 (OLP-82), LWVYHTQGYFPDWQNY, was promiscuous as it was restricted by 5 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---

Displaying record number 201748

Download this epitope record as JSON.

HXB2 Location	Nef(184-199) DNA(9346..9393)	Nef Epitope Map
Author Location	Nef
Epitope	KFDSRLAFHHMARELH	Epitope Alignment
Epitope Name	OLP-92
Species (MHC/HLA)	human(DRB1*03:02, DRB1*13:02, DRB1*13:03, DRB3*03:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ, HLA binding
Keywords	binding affinity, immunodominance, HLA cross-presentation

Notes

• 67 Gag and Nef peptides restricted by HLA-DRB1 were characterized immunologically in 17 controllers and 9 progressors. HLA allele DRB1*15:02 was associated with low HIV-1 viremia and could promiscuously present peptides with lower avidity. HLA DRB1*03:01, however, was associated with high viremia and specific presentation of peptides. Moreover, Nef peptides were exclusively restricted by HLA-DRB1 variants linked with low viremia. Individuals with low viremia-linked HLA-DRB1 alleles also had greater breadth of HIV-specific CD4+ T cell responses. DRB1 allelic expression can impact HIV replication.
• Overlapping peptide-92 (OLP-92), KFDSRLAFHHMARELH, was promiscuous as it was restricted by 4 different HLA-DR across the HIV proteome as determined by IFN-γ EliSpot.

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.

---