Search T Helper/CD4+ T-Cell Epitope Database

Found 14 matching records:

Displaying record number 201648

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HXB2 Location	Gag(9-26) p17(9-26) DNA(814..867)	Gag Epitope Map
Author Location	p17(9-26)
Epitope	`SGGELDRWEKIRLRPGGK`	Epitope Alignment
Epitope Name	OLP 2
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
10% of subjects responded to this immunodominant Gag-p17 peptide SGGELDRWEKIRLRPGGK.

References

Ranasinghe2012 Srinika Ranasinghe, Michael Flanders, Sam Cutler, Damien Z. Soghoian, Musie Ghebremichael, Isaiah Davis, Madelene Lindqvist, Florencia Pereyra, Bruce D. Walker, David Heckerman, and Hendrik Streeck. HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome. J. Virol., 86(1):277-283, Jan 2012. PubMed ID: 22031937. Show all entries for this paper.

Displaying record number 201646

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HXB2 Location	Gag(25-41) p17(25-41) DNA(862..912)	Gag Epitope Map
Author Location	p17(25-41)
Epitope	`GKKKYKLKHIVWASREL`	Epitope Alignment
Epitope Name	OLP 4
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
11% of subjects responded to this immunodominant Gag-p17 peptide GKKKYKLKHIVWASREL.

References

Displaying record number 201635

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HXB2 Location	Gag(37-51) p17(37-51) DNA(898..942)	Gag Epitope Map
Author Location	p17(37-51)
Epitope	`ASRELERFAVNPGLL`	Epitope Alignment
Epitope Name	OLP 6
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, elite controllers, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest rations being found in elite controllers and the highest in high-VL progressors.
Immunodominant Gag peptide ASRELERFAVNPGLL was associated with spontaneous control, independent of the variation in HLA haplotypes. 18% of subjects responded to this peptide.

References

Displaying record number 201649

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HXB2 Location	Gag(42-58) p17(42-58) DNA(913..963)	Gag Epitope Map
Author Location	p17(9-26)
Epitope	`ERFAVNPGLLETSEGCR`	Epitope Alignment
Epitope Name	OLP 7
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
10% of subjects responded to this immunodominant Gag-p17 peptide ERFAVNPGLLETSEGCR.

References

Displaying record number 201636

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HXB2 Location	Gag(163-179) p24(31-47) DNA(1276..1326)	Gag Epitope Map
Author Location	p24(31-47)
Epitope	`AFSPEVIPMFSALSEGA`	Epitope Alignment
Epitope Name	OLP 23
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, elite controllers

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest rations being found in elite controllers and the highest in high-VL progressors.
Immunodominant Gag peptide AFSPEVIPMFSALSEGA was associated with spontaneous control, independent of the variation in HLA haplotypes. 11% of subjects responded to this peptide.

References

Displaying record number 201640

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HXB2 Location	Gag(265-282) p24(133-150) DNA(1582..1635)	Gag Epitope Map
Author Location	p24(133-150)
Epitope	`WIILGLNKIVRMYSPTSI`	Epitope Alignment
Epitope Name	OLP 37
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
14% of subjects responded to this immunodominant Gag peptide WIILGLNKIVRMYSPTSI.

References

Displaying record number 201619

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HXB2 Location	Gag(296-313) p24(164-181) DNA(1675..1728)	Gag Epitope Map
Author Location	p24(164-181)
Epitope	`YVDRFYKTLRAEQASQEV`	Epitope Alignment
Epitope Name	OLP 41
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, elite controllers

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest rations being found in elite controllers and the highest in high-VL progressors.
Immunodominant Gag peptide YVDRFYKTLRAEQASQEV was associated with spontaneous control, independent of the variation in HLA haplotypes. 40% of subjects responded to this peptide.

References

Displaying record number 201645

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HXB2 Location	Gag(312-326) p24(180-194) DNA(1723..1767)	Gag Epitope Map
Author Location	p24(180-193)
Epitope	`EVKNWMTETLLVQNA`	Epitope Alignment
Epitope Name	OLP 43
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
11% of subjects responded to this immunodominant Gag-p24 peptide EVKNWMTETLLVQNA.

References

Displaying record number 201641

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HXB2 Location	gp160(30-46) gp120(30-46) DNA(6312..6362)	gp160 Epitope Map
Author Location	gp120(30-46)
Epitope	`AAEQLWVTVYYGVPVWK`	Epitope Alignment
Epitope Name	OLP 293
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
14% of subjects responded to this immunodominant Env-gp120 peptide AAEQLWVTVYYGVPVWK.

References

Displaying record number 201643

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HXB2 Location	gp160(88-105) gp120(88-105) DNA(6486..6539)	gp160 Epitope Map
Author Location	gp120(88-105)
Epitope	`NVTENFNMWKNNMVEQMH`	Epitope Alignment
Epitope Name	OLP 301
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
13% of subjects responded to this immunodominant Env-gp120 peptide NVTENFNMWKNNMVEQMH.

References

Displaying record number 201638

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HXB2 Location	gp160(207-224) gp120(207-224) DNA(6843..6896)	gp160 Epitope Map
Author Location	gp120(207-224)
Epitope	`KVSFEPIPIHYCAPAGFA`	Epitope Alignment
Epitope Name	OLP 316
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
Immunodominant Env peptide KVSFEPIPIHYCAPAGFA was associated with high viremia, independent of the variation in HLA haplotypes, and almost exclusively recognized by HIV progressors. 16% of subjects responded to this peptide.

References

Displaying record number 201644

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HXB2 Location	gp160(572-588) gp41(61-77) DNA(7938..7988)	gp160 Epitope Map
Author Location	gp41(61-77)
Epitope	`GIKQLQARVLAVERYLK`	Epitope Alignment
Epitope Name	OLP 365
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
12% of subjects responded to this immunodominant Env-gp41 peptide GIKQLQARVLAVERYLK.

References

Displaying record number 201639

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HXB2 Location	Nef(81-97) DNA(9037..9087)	Nef Epitope Map
Author Location	Nef(81-97)
Epitope	`YKAAVDLSHFLKEKGGL`	Epitope Alignment
Epitope Name	OLP 78
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
16% of subjects responded to this immunodominant Nef peptide YKAAVDLSHFLKEKGGL.

References

Displaying record number 201647

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HXB2 Location	Nef(176-193) DNA(9322..9375)	Nef Epitope Map
Author Location	Nef(176-193)
Epitope	`PEKEVLVWKFDSRLAFHH`	Epitope Alignment
Epitope Name	OLP 91
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD4 T-cell Elispot - IFNγ
Keywords	immunodominance, novel epitope

Notes

93 treatment-naive subjects in various stages of HIV-1 infection were analyzed for CD4 T-cell responses to the HIV B clade proteome using 410 overlapping peptides (OLPs). HTL responses were detected in 92% patients and breadth of these Gag responses were inversely correlated to viral load (VL). Targeting of 3 immunodominant Gag peptides was found to be linked to control of HIV infection.
Gag/Env mean response ratios were associated with effective immunity, and a robust marker of viral control, the lowest ratios being found in elite controllers and the highest in high-VL progressors.
11% of subjects responded to this immunodominant Nef peptide PEKEVLVWKFDSRLAFHH.