Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 285

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HXB2 Location	gp160(484-496) gp120(484-496) DNA(7674..7712)	gp160 Epitope Map
Author Location	gp120(484-496 HXB2)
Epitope	`YKYKVVKIEPLGV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	macaque(Mamu-DRB*W201)
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	DNA
Vaccine strain	B clade HXB2
Vaccine component	Env

Notes

Variants of this epitope with substitutions at position 490(K) retained ability to bind to MHC class II, but failed to induce proliferation/cytokine secretion in HIV-1 env-specific CD4+ Th cells.
The modified peptide antagonized the wildtype peptide-induced proliferative response.

References

Lekutis1998 C. Lekutis and N. L. Letvin. Substitutions in a Major Histocompatibility Complex Class II-Restricted Human Immunodeficiency Virus Type 1 gp120 Epitope Can Affect CD4+ T-Helper-Cell Function. J. Virol., 72:5840-5844, 1998. PubMed ID: 9621044. Show all entries for this paper.