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Displaying record number 398

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HXB2 Location	Pol(86-94) Protease(30-38) DNA(2340..2366)	Pol Epitope Map
Author Location	Pol( subtype B)
Epitope	DTVLEEMNL	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(A*68:02)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	subtype comparisons

Notes

• HIV-specific CTL were found in exposed seronegative prostitutes from Nairobi---these CTL may confer protection.
• Seroprevalence in this cohort is 90-95% and their HIV-1 exposure is among the highest in the world.
• Most isolated HIV strains are clade A in Nairobi, although clades C and D are also found -- B clade epitopes are often cross-reactive, however stronger responses are frequently observed using A or D clade versions of epitopes.
• This epitope is conserved among B and D clade viruses.
• The Clade A version of the epitope: DTVLEDINL.
• This epitope was recognized by two different exposed and uninfected prostitutes.
• This epitope was identified by screening 49 HIV-1 peptides with the predicted A*6802 anchor residue motif x(VT)xxxxxx(VL)
• Database note: First author "Rowland-Jones" is also found as "RowlandJones" on annotated papers in this database.

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.

Displaying record number 57331

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HXB2 Location	Pol(86-94) Protease(30-38) DNA(2340..2366)	Pol Epitope Map
Author Location	Pol
Epitope	DTVLEEMNL	Epitope Alignment
Subtype	A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA)	human(A*68:02)
Immunogen	HIV-1 infection
Country	Burkina Faso
Experimental methods	Other
Keywords	drug resistance

Notes

• Drug-associated mutations were analyzed in HIV-1 pol gene from drug-naive patients in Burkina Faso. 12.5% of all mutations were drug resistance-associated, suggesting either transmission from an ART-treated tramsitter or prior undocumented use of ART by the subject. Subtype specific polymorphisms were also seen, some of them within CTL epitopes.
• B-consensus HLA-A*6802-restricted epitope DTVLEEMNL was found as variant DTVLEEiNL in Burkina Faso virus subtype CRF02.AG and CRF09.cpx sequences. Variant DTVLEdiNL was seen in subtypes CRF06.cpx and A. 5% Burkinabe carry HLA-A*6802.

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.