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HIV Molecular Immunology Database

Search CTL/CD8+ T-Cell Epitope Database

Found 11 matching records:

Displaying record number 54569

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location RT(3-12)
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 401

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location RT( LAI)
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Subtype B
Species (MHC/HLA) human(A2, B61)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.


Displaying record number 52879

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location Pol
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Epitope Name 1307
Subtype multiple
Species (MHC/HLA) human(A2, B61, B7, B8)
Immunogen HIV-1 infection
Patient MHC/HLA A24, A3, B38, B7, Cw7; A29, A30, B44, B8, C*16, Cw7
Country United States
Experimental methods T-cell Elispot
Keywords binding affinity, computational prediction, HLA cross-presentation, novel epitope

Notes

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.


Displaying record number 1629

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location Pol
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Species (MHC/HLA) human(B7)
Immunogen  
Experimental methods  
Keywords  

Notes

References

DeGroot2001 A. S. De Groot, A. Bosma, N. Chinai, J. Frost, B. M. Jesdale, M. A. Gonzalez, W. Martin, and C. Saint-Aubin. From genome to vaccine: in silico predictions, ex vivo verification. Vaccine, 19(31):4385-95, 14 Aug 2001. PubMed ID: 11483263. Show all entries for this paper.


Displaying record number 59111

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location Pol(158-167)
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Epitope Name SL10
Subtype C
Species (MHC/HLA) human(B*81)
Immunogen HIV-1 infection
Patient MHC/HLA EC01: A*29, A*30, B*44, B*81:01, C*07, C*18
Country United Kingdom, Zambia
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Other, Tetramer binding
Keywords kinetics, elite controllers and/or long-term non-progressors

Notes

References

Smith2015 Nicola M. G. Smith, Petra Mlcochova, Sarah A. Watters, Marlene M. I. Aasa-Chapman, Neil Rabin, Sally Moore, Simon G. Edwards, Jeremy A. Garson, Paul R. Grant, R. Bridget Ferns, Angela Kashuba, Neema P. Mayor, Jennifer Schellekens, Steven G. E. Marsh, Andrew J. McMichael, Alan S. Perelson, Deenan Pillay, Nilu Goonetilleke, and Ravindra K. Gupta. Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo. Clin. Infect. Dis., 61(1):120-128, 1 Jul 2015. PubMed ID: 25778749. Show all entries for this paper.


Displaying record number 54623

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location Pol
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Show epitope variants
Epitope Name SL10
Subtype C
Species (MHC/HLA) human(B*81:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, HLA associated polymorphism, elite controllers and/or long-term non-progressors

Notes

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 53931

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location ( C consensus)
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Subtype C
Species (MHC/HLA) human(B*81:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope, HLA associated polymorphism

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 56487

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location RT
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Subtype C
Species (MHC/HLA) human(B*81:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and/or reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 61686

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location Pol(158-167)
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Show epitope variants
Epitope Name Pol-SL10
Subtype C
Species (MHC/HLA) human(B*81:01)
Immunogen HIV-1 infection
Patient MHC/HLA 133-C: A*68:01, A*74:01, B*58:02, B*81:01, C*04:01, C*06:02; 133-M: A*03:01, A*68:01, B*42:01, B*58:02, C*06:02, C*12:04
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords dynamics, responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 62722

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location Pol(163-171)
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Epitope Name SL10
Species (MHC/HLA) human
Immunogen vaccine
Patient MHC/HLA 831: A*26:01, A*68:02, B*53:01, B*81:01, C*04:01; 861: A*02:05, A*36:01, B*27:03, B*53:01, C*02:02, C*04:01; 8106: A*23:01, A*29:02, B*42:01, B*57:03, C*07:01, C*17:01
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA), HIVconsv
Vaccine component Int, Nef, p17 Gag, RT, other

Notes

References

Mohamed2020 Yehia S. Mohamed, Nicola J. Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Francesca Siliquini, Zara Hannoun, Alison Crook, Peter Hayes, Patricia E. Fast, Gaudensia Mutua, Walter Jaoko, Sandra Silva-Arrieta, Anuska Llano, Christian Brander, Masafumi Takiguchi, and Tomáš Hanke. Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya. Vaccines, 8(2), 29 May 2020. PubMed ID: 32485938. Show all entries for this paper.


Displaying record number 54203

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HXB2 Location Pol(158-167)
RT(3-12)
DNA(2556..2585)
Pol Epitope Map
Author Location RT(3-12)
Epitope SPIETVPVKL Epitope Alignment
SPIETVPVKL epitope logo
Epitope Name SL10
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords supertype, HLA cross-presentation, TCR usage, HLA associated polymorphism

Notes

References

Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.


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