Found 11 matching records:
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | RT(3-12) | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A*02) | |
Immunogen | HIV-1 infection | |
Country | United States | |
Experimental methods | Intracellular cytokine staining, Other | |
Keywords | rate of progression, escape, mutation acquisition |
Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | RT( LAI) | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Subtype | B | |
Species (MHC/HLA) | human(A2, B61) | |
Immunogen | HIV-1 infection | |
Experimental methods | ||
Keywords |
vanderBurg1997 S. H. van der Burg, M. R. Klein, O. Pontesilli, A. M. Holwerda, J. Drijfhout, W. M. Kast, F. Miedema, and C. J. M. Melief. HIV-1 Reverse Transcriptase-Specific CTL against Conserved Epitopes Do Not Protect against Progression to AIDS. J. Immunol., 159:3648-3654, 1997. PubMed ID: 9317165. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Epitope Name | 1307 | |
Subtype | multiple | |
Species (MHC/HLA) | human(A2, B61, B7, B8) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | A24, A3, B38, B7, Cw7; A29, A30, B44, B8, C*16, Cw7 | |
Country | United States | |
Experimental methods | T-cell Elispot | |
Keywords | binding affinity, computational prediction, HLA cross-presentation, novel epitope |
DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Species (MHC/HLA) | human(B7) | |
Immunogen | ||
Experimental methods | ||
Keywords |
DeGroot2001 A. S. De Groot, A. Bosma, N. Chinai, J. Frost, B. M. Jesdale, M. A. Gonzalez, W. Martin, and C. Saint-Aubin. From genome to vaccine: in silico predictions, ex vivo verification. Vaccine, 19(31):4385-95, 14 Aug 2001. PubMed ID: 11483263. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(158-167) | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Epitope Name | SL10 | |
Subtype | C | |
Species (MHC/HLA) | human(B*81) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | EC01: A*29, A*30, B*44, B*81:01, C*07, C*18 | |
Country | United Kingdom, Zambia | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Other, Tetramer binding | |
Keywords | kinetics, elite controllers and/or long-term non-progressors |
Smith2015 Nicola M. G. Smith, Petra Mlcochova, Sarah A. Watters, Marlene M. I. Aasa-Chapman, Neil Rabin, Sally Moore, Simon G. Edwards, Jeremy A. Garson, Paul R. Grant, R. Bridget Ferns, Angela Kashuba, Neema P. Mayor, Jennifer Schellekens, Steven G. E. Marsh, Andrew J. McMichael, Alan S. Perelson, Deenan Pillay, Nilu Goonetilleke, and Ravindra K. Gupta. Proof-of-Principle for Immune Control of Global HIV-1 Reactivation In Vivo. Clin. Infect. Dis., 61(1):120-128, 1 Jul 2015. PubMed ID: 25778749. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | Pol | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | SL10 | |
Subtype | C | |
Species (MHC/HLA) | human(B*81:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, escape, HLA associated polymorphism, elite controllers and/or long-term non-progressors |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | ( C consensus) | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*81:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | rate of progression, optimal epitope, HLA associated polymorphism |
Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | RT | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Subtype | C | |
Species (MHC/HLA) | human(B*81:01) | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ | |
Keywords | viral fitness and/or reversion, HLA associated polymorphism |
Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(158-167) | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Show epitope variants | ||
Epitope Name | Pol-SL10 | |
Subtype | C | |
Species (MHC/HLA) | human(B*81:01) | |
Immunogen | HIV-1 infection | |
Patient MHC/HLA | 133-C: A*68:01, A*74:01, B*58:02, B*81:01, C*04:01, C*06:02; 133-M: A*03:01, A*68:01, B*42:01, B*58:02, C*06:02, C*12:04 | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other | |
Keywords | dynamics, responses in children, mother-to-infant transmission, rate of progression, escape |
Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | Pol(163-171) | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Epitope Name | SL10 | |
Species (MHC/HLA) | human | |
Immunogen | vaccine | |
Patient MHC/HLA | 831: A*26:01, A*68:02, B*53:01, B*81:01, C*04:01; 861: A*02:05, A*36:01, B*27:03, B*53:01, C*02:02, C*04:01; 8106: A*23:01, A*29:02, B*42:01, B*57:03, C*07:01, C*17:01 | |
Country | Kenya | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining | |
Keywords | vaccine-induced immune responses |
Vaccine type | DNA, modified vaccinia Ankara (MVA), HIVconsv |
---|---|
Vaccine component | Int, Nef, p17 Gag, RT, other |
Mohamed2020 Yehia S. Mohamed, Nicola J. Borthwick, Nathifa Moyo, Hayato Murakoshi, Tomohiro Akahoshi, Francesca Siliquini, Zara Hannoun, Alison Crook, Peter Hayes, Patricia E. Fast, Gaudensia Mutua, Walter Jaoko, Sandra Silva-Arrieta, Anuska Llano, Christian Brander, Masafumi Takiguchi, and Tomáš Hanke. Specificity of CD8+ T-Cell Responses Following Vaccination with Conserved Regions of HIV-1 in Nairobi, Kenya. Vaccines, 8(2), 29 May 2020. PubMed ID: 32485938. Show all entries for this paper.
Download this epitope record as JSON.
HXB2 Location | Pol(158-167) RT(3-12) DNA(2556..2585) |
Pol Epitope Map |
---|---|---|
Author Location | RT(3-12) | |
Epitope |
SPIETVPVKL
|
Epitope Alignment
|
Epitope Name | SL10 | |
Subtype | C | |
Species (MHC/HLA) | human | |
Immunogen | HIV-1 infection | |
Country | South Africa | |
Experimental methods | CD8 T-cell Elispot - IFNγ, Other, Tetramer binding | |
Keywords | supertype, HLA cross-presentation, TCR usage, HLA associated polymorphism |
Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.
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