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HIV Molecular Immunology Database

Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 52679

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr(34-)
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Epitope Name Vpr34
Species (MHC/HLA) human, transgenic mouse(A2)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords binding affinity, subtype comparisons, computational prediction

Vaccine Details

Vaccine type peptide
Vaccine component Vpr
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

Corbet2003 Sylvie Corbet, Henrik Vedel Nielsen, Lasse Vinner, Sanne Lauemoller, Dominic Therrien, Sheila Tang, Gitte Kronborg, Lars Mathiesen, Paul Chaplin, Søren Brunak, Søren Buus, and Anders Fomsgaard. Optimization and Immune Recognition of Multiple Novel Conserved HLA-A2, Human Immunodeficiency Virus Type 1-Specific CTL Epitopes. J. Gen. Virol., 84(Pt 9):2409-2421, Sep 2003. PubMed ID: 12917462. Show all entries for this paper.


Displaying record number 56075

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr(158-)
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Show epitope variants
Epitope Name Vpr34
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, escape, acute/early infection

Notes

References

Fomsgaard2008 Anders Fomsgaard, Lasse Vinner, Dominic Therrien, Louise B. Jørgensen, Claus Nielsen, Lars Mathiesen, Court Pedersen, and Sylvie Corbet. Full-Length Characterization of A1/D Intersubtype Recombinant Genomes from a Therapy-Induced HIV Type 1 Controller during Acute Infection and His Noncontrolling Partner. AIDS Res. Hum. Retroviruses, 24(3):463-472, Mar 2008. PubMed ID: 18373434. Show all entries for this paper.


Displaying record number 55390

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location  
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Show epitope variants
Epitope Name Vpr 34
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country Denmark
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords variant cross-reactivity

Notes

References

Thorn2007 Mette Thorn, Sheila Tang, Dominic Therrien, Henrik Kløverpris, Lasse Vinner, Gitte Kronborg, Jan Gerstoft, Sylvie Corbet, and Anders Fomsgaard. Sequence Conservation of Subdominant HLA-A2-Binding CTL Epitopes in HIV-1 Clinical Isolates and CD8+ T-Lymphocyte Cross-Recognition May Explain the Immune Reaction in Infected Individuals. APMIS, 115(6):757-768, Jun 2007. PubMed ID: 17550385. Show all entries for this paper.


Displaying record number 56260

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location  
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Subtype C
Species (MHC/HLA) human(B*07:02, B*42:01, B*81:01)
Immunogen HIV-1 infection
Patient MHC/HLA A*23:01, A*29:02, B*41:01, B*42:01, C*17:01
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 53314

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location ( C consensus)
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Subtype C
Species (MHC/HLA) human(B*07:02, B*42:01, B*81:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA cross-presentation, characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 62243

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr(34-42)
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Show epitope variants
Epitope Name Vpr-FL9
Subtype C
Species (MHC/HLA) human(B*42)
Immunogen HIV-1 infection
Patient MHC/HLA 021-C: A*02:05, A*29:02, B*42:01, B*44:03, C*02:10, C*17:01; 021-M: A*02:05, A*33:01, B*42:01, B*44:03, C*02:10, C*17:01
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords dynamics, responses in children, mother-to-infant transmission, rate of progression, escape

Notes

References

Leitman2017 Ellen M. Leitman, Christina F. Thobakgale, Emily Adland, M. Azim Ansari, Jayna Raghwani, Andrew J. Prendergast, Gareth Tudor-Williams, Photini Kiepiela, Joris Hemelaar, Jacqui Brener, Ming-Han Tsai, Masahiko Mori, Lynn Riddell, Graz Luzzi, Pieter Jooste, Thumbi Ndung'u, Bruce D. Walker, Oliver G. Pybus, Paul Kellam, Vivek Naranbhai, Philippa C. Matthews, Astrid Gall, and Philip J. R. Goulder. Role of HIV-Specific CD8+ T Cells in Pediatric HIV Cure Strategies after Widespread Early Viral Escape. J. Exp. Med., 214(11):3239-3261, 6 Nov 2017. PubMed ID: 28983013. Show all entries for this paper.


Displaying record number 59157

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr(34-42)
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Epitope Name FL9-Vpr
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Tetramer binding
Keywords TCR usage, characterizing CD8+ T cells

Notes

References

Kloverpris2014a Henrik N. Kløverpris, Reuben McGregor, James E McLaren, Kristin Ladell, Anette Stryhn, Catherine Koofhethile, Jacqui Brener, Fabian Chen, Lynn Riddell, Luzzi Graziano, Paul Klenerman, Alasdair Leslie, Søren Buus, David A. Price, and Philip Goulder. Programmed Death-1 Expression on HIV-1-Specific CD8+ T Cells Is Shaped by Epitope Specificity, T-Cell Receptor Clonotype Usage and Antigen Load. AIDS, 28(14):2007-2021, 10 Sep 2014. PubMed ID: 24906112. Show all entries for this paper.


Displaying record number 57888

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location RT
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Patient MHC/HLA CAP239: A*01:01, A*29:02, B*42:01, B*58:01, C*06:02, C*07:02
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Chopera2011 D. R. Chopera, M. Mlotshwa, Z. Woodman, K. Mlisana, D. de Assis Rosa, D. P. Martin, S. Abdool Karim, C. M. Gray, C. Williamson, and CAPRISA 002 Study Team. Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals. J. Virol., 85(14):7070-7080, Jul 2011. PubMed ID: 21613398. Show all entries for this paper.


Displaying record number 57991

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location  
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Country South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Tetramer binding
Keywords computational prediction, optimal epitope

Notes

References

ErupLarsen2011 Malene Erup Larsen, Henrik Kloverpris, Anette Stryhn, Catherine K. Koofhethile, Stuart Sims, Thumbi Ndung'u, Philip Goulder, Søren Buus, and Morten Nielsen. HLArestrictor---A Tool for Patient-Specific Predictions of HLA Restriction Elements and Optimal Epitopes within Peptides. Immunogenetics, 63(1):43-55, Jan 2011. PubMed ID: 21079948. Show all entries for this paper.


Displaying record number 59438

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr(34-42)
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Show epitope variants
Epitope Name Vpr-FL9
Subtype C
Species (MHC/HLA) human(B*42:01)
Immunogen HIV-1 infection
Country Botswana, South Africa, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, Other, Tetramer binding
Keywords immunodominance, escape, optimal epitope, novel epitope

Notes

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 58710

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr(34-42)
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Show epitope variants
Epitope Name Vpr-FL9
Subtype C
Species (MHC/HLA) human(B*42:01, B*42:02)
Immunogen HIV-1 infection
Patient MHC/HLA A*30:01, B*42:01, C*17:01; A*30:01, B*42:02, C*17:01
Country Botswana, South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, HLA associated polymorphism, novel epitope

Notes

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 56118

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Epitope Name Vpr1125
Subtype C
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, computational prediction, HLA associated polymorphism

Notes

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.


Displaying record number 55981

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HXB2 Location Vpr(34-42)
DNA(5658..5684)
Vpr Epitope Map
Author Location Vpr
Epitope FPRPWLHGL Epitope Alignment
FPRPWLHGL epitope logo
Show epitope variants
Epitope Name FL9(Vpr)
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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