Search CTL/CD8+ T-Cell Epitope Database

Found 82 matching records:

Displaying record number 53546

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HXB2 Location	Gag(18-26) p17(18-26) DNA(841..867)	Gag Epitope Map
Author Location	Gag(18-26)
Epitope	`KIRLRPGGK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.

Displaying record number 53496

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HXB2 Location	Gag(20-28) p17(20-28) DNA(847..873)	Gag Epitope Map
Author Location	Gag
Epitope	`RLRPGGKKK`	Epitope Alignment
Epitope Name	RK9
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 9, rrlpggkkR, was found in the most polymorphic residue in the epitope.This was shared between clades B and C.

References

Displaying record number 53502

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HXB2 Location	Gag(71-79) p17(71-79) DNA(1000..1026)	Gag Epitope Map
Author Location	Gag
Epitope	`GSEELRSLY`	Epitope Alignment
Epitope Name	GL9
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 9, gseelrslF, was found in the most polymorphic residue in the epitope. These were shared between clades B and C.

References

Displaying record number 53495

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	Gag
Epitope	`SLYNTVATL`	Epitope Alignment
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Two escape mutations, at positions 3 and 8, slFntvatl and slyntvaVl, were found in the most polymorphic residues in the epitope. These were shared between clades B and C. One escape mutation, at position 6, slyntIatl, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53506

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HXB2 Location	Gag(123-132) p17(123-132) DNA(1156..1185)	Gag Epitope Map
Author Location	Gag
Epitope	`GNSSQVSQNY`	Epitope Alignment
Epitope Name	GY10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 2, gKssqvsqny, was found not to correspond to the most polymorphic residues in the epitope. This is a novel partially mapped epitope.

References

Displaying record number 53489

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HXB2 Location	Gag(146-155) p24(14-23) DNA(1225..1254)	Gag Epitope Map
Author Location	Gag
Epitope	`AISPRTLNAW`	Epitope Alignment
Epitope Name	IW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Two escape mutations, at positions 1 (A146P) and 2 (I147L), were found in the most polymorphic residue in the epitope. Both were shared between clades B and C. Both were significantly more variable in persons expressing HLA-B57.

References

Displaying record number 53512

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	Gag
Epitope	`ISPRTLNAW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, epitope processing, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Characteristic changes in B57 epitopes in B57+ people were mapped: ISPRTLNAW often has the substitution Lsprtlnaw, as well as the proximal A->P substitution Pisprtlnaw.

References

Displaying record number 53510

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	Gag
Epitope	`ISPRTLNAW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(C*06:02)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
I->L (Lsprtlnaw) is associated with HLA C*0602.

References

Displaying record number 53493

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Epitope Name	KF11
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was quite conserved in people carrying B57, but two substitutions were found in 11 B57+ individuals tested: kNfspevipmf and kafspeIipmf.

References

Displaying record number 53549

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag(162-172)
Epitope	`KAFSPEVIPMF`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53548

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HXB2 Location	Gag(216-224) p24(84-92) DNA(1435..1461)	Gag Epitope Map
Author Location	Gag(216-224)
Epitope	`HPVHAGPIA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53488

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HXB2 Location	Gag(240-249) p24(108-117) DNA(1507..1536)	Gag Epitope Map
Author Location	Gag
Epitope	`TSTLQEQIGW`	Epitope Alignment
Epitope Name	TW10
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Two escape mutations, at positions 3 (T242N) and 9 (G248A), were found in the most polymorphic residues in the epitope. Both were shared between clades B and C. Both were significantly more variable in persons expressing HLA-B57.

References

Displaying record number 53497

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HXB2 Location	Gag(263-272) p24(131-140) DNA(1576..1605)	Gag Epitope Map
Author Location	Gag
Epitope	`KRWIILGLNK`	Epitope Alignment
Epitope Name	KK10
Subtype	B
Species (MHC/HLA)	human(B27)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 6, krwiiMglnk, was found in the most polymorphic residue in the epitope.This was shared between clades B and C. One escape mutation, at position 2, kTwiilglnk, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53567

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HXB2 Location	Gag(298-306) p24(166-174) DNA(1681..1707)	Gag Epitope Map
Author Location	Gag(298-306)
Epitope	`DRFYKTLRA`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53568

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HXB2 Location	Gag(306-316) p24(174-184) DNA(1705..1737)	Gag Epitope Map
Author Location	Gag(306-316)
Epitope	`AEQASADVKNW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53557

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HXB2 Location	Gag(306-316) p24(174-184) DNA(1705..1737)	Gag Epitope Map
Author Location	Gag(306-316)
Epitope	`AEQASQDVKNW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B44)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53492

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HXB2 Location	Gag(308-316) p24(176-184) DNA(1711..1737)	Gag Epitope Map
Author Location	Gag
Epitope	`QASQEVKNW`	Epitope Alignment
Epitope Name	QW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 5, qasqDvknw, was found in the most polymorphic residue in the epitope. This was shared between clades B and C. The most common substitution in people carrying B57 was in position 3, qaTqevknw.

References

Displaying record number 53501

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HXB2 Location	Gag(349-359) p24(217-227) DNA(1834..1866)	Gag Epitope Map
Author Location	Gag
Epitope	`ACQGVGGPGHK`	Epitope Alignment
Epitope Name	AK11
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 9, acqgvggpShk, was found in the most polymorphic residues in the epitope. These were shared between clades B and C.

References

Displaying record number 53547

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HXB2 Location	Gag(355-363) p24(223-231) DNA(1852..1878)	Gag Epitope Map
Author Location	Gag(355-363)
Epitope	`GPGHKARVL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53507

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HXB2 Location	Gag(371-380) p2p7p1p6(8-17) DNA(1900..1929)	Gag Epitope Map
Author Location	Gag
Epitope	`TNSANIMMQR`	Epitope Alignment
Epitope Name	TR10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 5, tnsaSimmqr, was found in the most polymorphic residues in the epitope. One escape mutation, at position 2,tTsanimmqr, was found not to correspond to the most polymorphic residues in the epitope. This is a novel partially mapped epitope.

References

Displaying record number 53569

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HXB2 Location	Gag(405-413) p2p7p1p6(42-50) DNA(2002..2028)	Gag Epitope Map
Author Location	Gag(405-413)
Epitope	`CRAPRKKGC`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B14)
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53533

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HXB2 Location	Gag(474-490) p2p7p1p6(111-127) DNA(2209..2259)	Gag Epitope Map
Author Location	Gag
Epitope	`QKQGTIDKELYPLASLK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This is a novel unmapped epitope. Two changes over time in the individual that recognized this peptide: QKQGTkDKELYPLvSLK

References

Displaying record number 53514

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HXB2 Location	Gag(481-500) p2p7p1p6(118-137) DNA(2230..2289)	Gag Epitope Map
Author Location	Gag
Epitope	`KEMYPLASLRSLFGNDPSSQ`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Novel unmapped epitope.
An S->L change was observed over time: KEMYPLASLRSLFGNDPlSQ

References

Displaying record number 53505

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HXB2 Location	Pol(54-62) Gag/Pol-TF(54)-Protease(6) DNA(2244..2270)	Pol Epitope Map
Author Location	Pol
Epitope	`FSFPQITLW`	Epitope Alignment
Epitope Name	FW9
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
An escape mutation at position 2, fNfpqitlw, was found in the most polymorphic residue in the epitope. This is a novel partially mapped epitope.

References

Displaying record number 53570

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HXB2 Location	Pol(59-67) Protease(3-11) DNA(2259..2285)	Pol Epitope Map
Author Location	Pol(60-68)
Epitope	`ITLWQRPLV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A28)
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53572

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HXB2 Location	Pol(86-94) Protease(30-38) DNA(2340..2366)	Pol Epitope Map
Author Location	Pol(87-95)
Epitope	`DTVLEEMNL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A28)
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53499

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HXB2 Location	Pol(283-290) RT(128-135) DNA(2931..2954)	Pol Epitope Map
Author Location	Pol
Epitope	`TAFTIPSI`	Epitope Alignment
Epitope Name	TI8
Subtype	B
Species (MHC/HLA)	human(B51)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 8, taftipsT, was found in the most polymorphic residue in the epitope. This was shared between clades B and C.

References

Displaying record number 53498

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HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location	Pol
Epitope	`SPAIFQSSM`	Epitope Alignment
Epitope Name	SM9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 7, spaifqCsm, was found in the most polymorphic residue in the epitope. This was shared between clades B and C.

References

Displaying record number 53551

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HXB2 Location	Pol(311-319) RT(156-164) DNA(3015..3041)	Pol Epitope Map
Author Location	Pol(312-320)
Epitope	`SPAIFQSSM`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53558

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	Pol(314-322)
Epitope	`AIFQSSMTK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53503

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HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	Pol
Epitope	`AIFQSSMTK`	Epitope Alignment
Epitope Name	AK9
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 9, aifqssmtI, was found not to correspond to the most polymorphic residues in the epitope.

References

Displaying record number 53491

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HXB2 Location	Pol(399-407) RT(244-252) DNA(3279..3305)	Pol Epitope Map
Author Location	Pol
Epitope	`IVLPEKDSW`	Epitope Alignment
Epitope Name	IW9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 2, was found in the most polymorphic residue in the epitope. This was shared between clades B and C. The position 2 mutation was significantly more common among persons expressing HLA-B57.

References

Displaying record number 53559

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HXB2 Location	Pol(424-432) RT(269-277) DNA(3354..3380)	Pol Epitope Map
Author Location	Pol(425-433)
Epitope	`QIYAGIKVK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53504

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HXB2 Location	Pol(424-432) RT(269-277) DNA(3354..3380)	Pol Epitope Map
Author Location	Pol
Epitope	`QIYPGIKVK`	Epitope Alignment
Epitope Name	QK9
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 9, qiypgikvR, was found not to correspond to the most polymorphic residues in the epitope.

References

Displaying record number 53500

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HXB2 Location	Pol(464-472) RT(309-317) DNA(3474..3500)	Pol Epitope Map
Author Location	Pol
Epitope	`ILKEPVHGV`	Epitope Alignment
Epitope Name	IV9
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Two escape mutations, at positions 3 ilRepvhgv, and 9 ilkepvhgA, were found not to correspond to the most polymorphic residues in the epitope.

References

Displaying record number 53561

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HXB2 Location	Pol(496-505) RT(341-350) DNA(3570..3599)	Pol Epitope Map
Author Location	Pol(497-506)
Epitope	`IYQEPFKNLK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53550

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HXB2 Location	Pol(511-521) RT(356-366) DNA(3615..3647)	Pol Epitope Map
Author Location	Pol(512-522)
Epitope	`RMRGAHTNDVK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53560

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HXB2 Location	Pol(675-683) RT(520-528) DNA(4107..4133)	Pol Epitope Map
Author Location	Pol(676-684)
Epitope	`QIIEQLIKK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53508

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HXB2 Location	Pol(708-717) RT(553)-Integrase(2) DNA(4206..4235)	Pol Epitope Map
Author Location	Pol
Epitope	`STGIRRVLFL`	Epitope Alignment
Epitope Name	SL10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
An escape mutation at position 6 (stgirKvlfl) was found not to correspond to the most polymorphic residues in the epitope. This is a novel partially mapped epitope.

References

Displaying record number 53509

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HXB2 Location	Pol(724-734) Integrase(9-19) DNA(4254..4286)	Pol Epitope Map
Author Location	Pol
Epitope	`QEEHEKYHSNW`	Epitope Alignment
Epitope Name	QW11
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 2, qAehekyhsnw, was found not to correspond to the most polymorphic residues in the epitope. This is a novel partially mapped epitope.

References

Displaying record number 53490

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HXB2 Location	Pol(838-847) Integrase(123-132) DNA(4596..4625)	Pol Epitope Map
Author Location	Pol
Epitope	`STTVKAACWW`	Epitope Alignment
Epitope Name	SW10
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Two escape mutations, at positions 2 and 3, were found in the most polymorphic residue in the epitope. These were shared between clades B and C. The T840N mutation at residue 2, sNtvkaacww, was significantly more common in persons expressing HLA-B57, often in conjunction with T841A or V sT[A/V]kaacww.

References

Displaying record number 53494

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HXB2 Location	Pol(888-896) Integrase(173-181) DNA(4746..4772)	Pol Epitope Map
Author Location	Pol
Epitope	`KTAVQMAVF`	Epitope Alignment
Epitope Name	KF9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was quite conserved in people carrying B57, but two substitutions were found in 11 B57+ individuals tested: Rtavqmavf and ktavqmavL.

References

Displaying record number 53552

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HXB2 Location	Pol(888-896) Integrase(173-181) DNA(4746..4772)	Pol Epitope Map
Author Location	Pol(889-897)
Epitope	`KTAVQMAVF`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53515

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HXB2 Location	Vif(17-26) DNA(5089..5118)	Vif Epitope Map
Author Location	Vif
Epitope	`RIRTWKSLVK`	Epitope Alignment
Epitope Name	RK10
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 6, rirtwNslvk, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53516

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HXB2 Location	Vif(31-39) DNA(5131..5157)	Vif Epitope Map
Author Location	Vif
Epitope	`VSKKAKGWI`	Epitope Alignment
Epitope Name	VI9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 1,Askkakwi, was found in the most polymorphic residue in the epitope.

References

Displaying record number 53517

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HXB2 Location	Vif(48-57) DNA(5182..5211)	Vif Epitope Map
Author Location	Vif
Epitope	`HPRISSEVHI`	Epitope Alignment
Epitope Name	HI10
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 2, hSrissevhi, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53562

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HXB2 Location	Vif(102-111) DNA(5344..5373)	Vif Epitope Map
Author Location	Vif(102-110)
Epitope	`LADQLIHLHY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B18)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53534

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HXB2 Location	Vif(127-135) DNA(5419..5445)	Vif Epitope Map
Author Location	Vif
Epitope	`HIVSPRCEY`	Epitope Alignment
		Show epitope variants
Epitope Name	HY9
Subtype	B
Species (MHC/HLA)	human(A29)
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 3, HIgSPRCEY, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53543

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HXB2 Location	Vif(158-168) DNA(5512..5544)	Vif Epitope Map
Author Location	Vif
Epitope	`KIKPPLPSVTK`	Epitope Alignment
Epitope Name	KK11
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 10, KIKPPLPSVkK, was found in the most polymorphic residue in the epitope.

References

Displaying record number 53518

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HXB2 Location	Vif(158-168) DNA(5512..5544)	Vif Epitope Map
Author Location	Vif
Epitope	`RIKPPLPSVTK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
RIKPPLPSVTK had to mutations overtime, in positions 1 and 10: KikpplpsvKk

References

Displaying record number 53535

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HXB2 Location	Vpr(1-18) DNA(5559..5612)	Vpr Epitope Map
Author Location	Vpr
Epitope	`MEQAPENQGLQREPYNEW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Novel unmapped epitope. A mutation occurred over time in an individual that reacted to this peptide: MEQAPENQGpQREPYNEW.

References

Displaying record number 53519

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HXB2 Location	Vpr(19-28) DNA(5613..5642)	Vpr Epitope Map
Author Location	Vpr
Epitope	`TLEILEELKN`	Epitope Alignment
		Show epitope variants
Epitope Name	TN10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One mutation, at position 1, Aleileelkn,occurred over time. This is a novel unmapped epitope, possibly associated with A3 supertype.

References

Displaying record number 53554

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HXB2 Location	Vpr(30-38) DNA(5646..5672)	Vpr Epitope Map
Author Location	Vpr(30-38)
Epitope	`AVRHFPRIW`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53525

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HXB2 Location	Vpr(34-42) DNA(5658..5684)	Vpr Epitope Map
Author Location	Vpr
Epitope	`FPRIWLHGL`	Epitope Alignment
Epitope Name	FL9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, B44, B7, Cw5, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 8, FPRIWLHdL was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53553

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HXB2 Location	Vpr(34-42) DNA(5658..5684)	Vpr Epitope Map
Author Location	Vpr(34-42)
Epitope	`FPRIWLHGL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53529

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HXB2 Location	Vpr(59-67) DNA(5733..5759)	Vpr Epitope Map
Author Location	Vpr
Epitope	`ALIRILQQL`	Epitope Alignment
Epitope Name	AL9
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 5, ALIRsLQQL, was found in the most polymorphic residue in the epitope. One escape mutation, at position 3,ALtRILQQL was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53530

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HXB2 Location	Tat(30-37) DNA(5918..5941)	Tat Epitope Map
Author Location	Tat
Epitope	`CCFHCQVC`	Epitope Alignment
Epitope Name	CC8
Subtype	B
Species (MHC/HLA)	human(C*12)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 3, CClHCQVC, was found in the most polymorphic residue in the epitope.

References

Displaying record number 53526

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HXB2 Location	Tat(58-69) DNA(6002..6037)	Tat Epitope Map
Author Location	Tat
Epitope	`APQGHPNNQVSI`	Epitope Alignment
		Show epitope variants
Epitope Name	AI12
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, B44, B7, Cw5, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 4, APQdHPNNQVSI, was found not to correspond to the most polymorphic residue in the epitope. This is a novel unmapped epitope.

References

Displaying record number 53520

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HXB2 Location	Rev(14-23) DNA(6009..6038)	Rev Epitope Map
Author Location	Rev
Epitope	`KTGRLIKLLY`	Epitope Alignment
Epitope Name	KY10
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 8, ktgrlikLly, was found in the most polymorphic residue in the epitope. One escape mutation, at position 5, ktgrFiklly was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53527

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HXB2 Location	Rev(51-60) DNA(8453..8482)	Rev Epitope Map
Author Location	Rev
Epitope	`QIRSLSGWIL`	Epitope Alignment
Epitope Name	QL10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, B44, B7, Cw5, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 7, QIRSLSeWIL was found not to correspond to the most polymorphic residue in the epitope. This is a novel unmapped epitope.

References

Displaying record number 53536

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HXB2 Location	Rev(56-64) DNA(8468..8494)	Rev Epitope Map
Author Location	Rev
Epitope	`SEWILSTHL`	Epitope Alignment
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 2,SkWILSTHL was found in the most polymorphic residue in the epitope. This is a novel unmapped epitope.

References

Displaying record number 53521

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HXB2 Location	Rev(66-81) DNA(8498..8545)	Rev Epitope Map
Author Location	Rev
Epitope	`RSAEPAPLQLPPLERL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Novel unmapped epitope.
RSAEPAPLQLPPLERL shows a mutation over time in position 6, RSAEPvPLQLPPLERL.

References

Displaying record number 53531

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HXB2 Location	Rev(67-75) DNA(8501..8527)	Rev Epitope Map
Author Location	Rev
Epitope	`SAEPVPLQL`	Epitope Alignment
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human(Cw5)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 5, SAEPgPLQL, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53537

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HXB2 Location	Rev(98-116) DNA(8594..8650)	Rev Epitope Map
Author Location	Rev
Epitope	`GSTQVSVESPTVLEPGTKE`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Novel unmapped epitope. A P->L change occurred in a patient that recognized this peptide, over time: GSTQVSVESlTVLEPGTKE

References

Displaying record number 53532

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HXB2 Location	Rev(101-110) DNA(8603..8632)	Rev Epitope Map
Author Location	Rev
Epitope	`QVLGESPTVL`	Epitope Alignment
		Show epitope variants
Epitope Name	QL10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Two escape mutations, at positions 5 and 7, QVLGkSPTVL and QVLGEStTVL, were found not to correspond to the most polymorphic residues in the epitope. This is a novel unmapped epitope.

References

Displaying record number 53528

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HXB2 Location	Vpu(62-82) DNA(6245..6307)	Vpu Epitope Map
Author Location	Vpu(65-81)
Epitope	`AALVEMGHDAPWVVDDL`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, B44, B7, Cw5, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Novel unmapped epitope. The third position was found to vary over time to AAfVEMGHDAPWVVDDL.

References

Displaying record number 53538

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HXB2 Location	Nef(11-20) DNA(8827..8856)	Nef Epitope Map
Author Location	Nef
Epitope	`VEWPAVRERM`	Epitope Alignment
Epitope Name	VM10
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 2, VgWPAVRERM, was found not to correspond to the most polymorphic residue in the epitope. This is a novel unmapped epitope.

References

Displaying record number 53556

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HXB2 Location	Nef(71-79) DNA(9007..9033)	Nef Epitope Map
Author Location	Nef(180-187)
Epitope	`TPQVPLRPM`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53564

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HXB2 Location	Nef(73-82) DNA(9013..9042)	Nef Epitope Map
Author Location	Nef(73-82)
Epitope	`QVPLRPMTYK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53522

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HXB2 Location	Nef(77-85) DNA(9025..9051)	Nef Epitope Map
Author Location	Nef
Epitope	`RPMTYKGAL`	Epitope Alignment
Epitope Name	RL9
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 4, RPMnYKGAL, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53539

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HXB2 Location	Nef(82-91) DNA(9040..9069)	Nef Epitope Map
Author Location	Nef
Epitope	`KAAVDLSHFL`	Epitope Alignment
Epitope Name	KL10
Subtype	B
Species (MHC/HLA)	human(Cw8)
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 6, KAAVDmSHFL, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53565

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HXB2 Location	Nef(84-92) DNA(9046..9072)	Nef Epitope Map
Author Location	Nef(84-92)
Epitope	`AVDLSHFLK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A11)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53542

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HXB2 Location	Nef(90-97) DNA(9064..9087)	Nef Epitope Map
Author Location	Nef
Epitope	`FLKEKGGL`	Epitope Alignment
Epitope Name	FL8
Species (MHC/HLA)	human(B8)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 5, FLKEnGGL, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53540

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HXB2 Location	Nef(92-105) DNA(9070..9111)	Nef Epitope Map
Author Location	Nef
Epitope	`KEKGGLEGLVYSQK`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Novel unmapped epitope.There was a V->A change KEKGGLEGLaYSQK over time in an individual that reacted with this peptide.

References

Displaying record number 53523

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HXB2 Location	Nef(106-115) DNA(9112..9141)	Nef Epitope Map
Author Location	Nef
Epitope	`RQDILDLWVY`	Epitope Alignment
Epitope Name	RY10
Subtype	B
Species (MHC/HLA)	human(Cw7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 9, RQDILDLWiY, was found in the most polymorphic residue in the epitope.

References

Displaying record number 53544

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HXB2 Location	Nef(116-125) DNA(9142..9171)	Nef Epitope Map
Author Location	Nef
Epitope	`HTQGYFPDWQ`	Epitope Alignment
Epitope Name	HQ10
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 1, nTQGYFPDWQ, was found in the most polymorphic residue in the epitope.

References

Displaying record number 53545

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HXB2 Location	Nef(120-128) DNA(9154..9180)	Nef Epitope Map
Author Location	Nef
Epitope	`YFPDWQDYT`	Epitope Alignment
Epitope Name	YT9
Subtype	B
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
One escape mutation, at position 7, YFPDWQnYT, was found not to correspond to the most polymorphic residue in the epitope.

References

Displaying record number 53566

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HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location	Nef(135-143)
Epitope	`YPLTFGWCY`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B18)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53563

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HXB2 Location	Nef(137-146) DNA(9205..9234)	Nef Epitope Map
Author Location	Nef(137-146)
Epitope	`LTFGWCFKLV`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Patient MHC/HLA	A11, A2, B18, B44, C*12, Cw5
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53555

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HXB2 Location	Nef(183-192) DNA(9343..9372)	Nef Epitope Map
Author Location	Nef(183-192)
Epitope	`WRFDSRLAFH`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
This epitope was reactive, but escape mutations did not accrue in it over time.

References

Displaying record number 53541

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HXB2 Location	Nef(186-194) DNA(9352..9378)	Nef Epitope Map
Author Location	Nef
Epitope	`DSRLAFHHV`	Epitope Alignment
Epitope Name	DV9
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A28, A29, B14, B44, Cw8
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
An escape mutation at position 7, DSRLAFqHV, was found not to correspond to the most polymorphic residue in the epitope. This is a novel unmapped epitope.

References

Displaying record number 53524

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HXB2 Location	Nef(190-206) DNA(9364..9414)	Nef Epitope Map
Author Location	Nef
Epitope	`AFRHMARELHPEYYKNC`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A3, B57, B7, Cw6, Cw7
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, escape, characterizing CD8+ T cells, viral fitness and reversion

Notes

Two-thirds of all mutations arising in non-envelope proteins during the transition from acute to chronic infection were found to be due to either CD8 T-cell-associated selective pressures or reversion of HLA-I-associated mutations selected in a previous host.The predominance of escape mutations at highly polymorphic sites was observed across different HIV-1 clades.
Novel unmapped epitope.
AFRHMARELHPEYYKNC acquired a substitution over time, AFRHMAREmHPEYYKNC.