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Displaying record number 61246

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HXB2 Location	Gag(180-188) p24(48-56) DNA(1327..1353)	Gag Epitope Map
Author Location	Gag
Epitope	`TPQDLNMML`	Epitope Alignment
		Show epitope variants
Epitope Name	TL9M7
Subtype	A, CRF01_AE, CRF02_AG
Species (MHC/HLA)	human(B42:01, B81:01)
Immunogen	HIV-1 infection
Country	Kenya, Tanzania
Experimental methods	CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other, Tetramer binding
Keywords	subtype comparisons, escape, variant cross-reactivity, HLA associated polymorphism

Notes

Minor viral TL9(TPQDLNTML) eptiope differences at P7, as well as host genetic variation (6 aa between HLAs B*42 and B*81) influence CTL response by eliciting distinct clonotypic populations, and different recognition and selection of variants. Subtype A elicited TL9M7-specific CTL populations with differing, diverse TCRVB genes and did not select viral variants.
Subtype A-TL9M7-specific CTL from ART-naive infected East African female subjects failed to induce immune-driven variation in the presence of B*42 or B*81 despite the presence of mutations at P3 and P7 in the absence of these two HLA alleles.
Epitope TL9M7, TPQDLNMML, is present in 75% of B*42^-/B*81^-; 66.7% of B*42⁺ subjects; and 88.9% of B*81⁺ subjects. Variants arise at positions 1, 3, 7 in TL9M7 without serious negative effects on viral fitness.

References

Geldmacher2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup. Minor Viral and Host Genetic Polymorphisms Can Dramatically Impact the Biologic Outcome of an Epitope-Specific CD8 T-Cell Response. Blood, 114(8):1553-1562, 20 Aug 2009. PubMed ID: 19542300. Show all entries for this paper.