Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 60505

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location	p17
Epitope	SLYNTVATL	Epitope Alignment
		Show epitope variants
Epitope Name	A2-SL9
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	ACS 19957: A*01, A*02, B*08:01, B*15; ACS 19885: A*01, A*02, B*08:01, B*27; ACS 19861: A*01, A*02, B*08:01, B*51; ACS 19453: A*01, A*02, B*08:01, B*38; ACS 19342: A*01, A*02, B*08:01, B*40; ACS 18840: A*02, B*08:01, B*27; ACS 18839: A*02:07, B*08:01, B*27; ACS 18785: A*01, A*02, B*07, B*08:01
Country	Netherlands
Experimental methods	Other, Tetramer binding
Keywords	TCR usage

Notes

• Eight asymptomatic, chronic HIV-1-infected, ART-naive, HLA-A*02+, B*08+ subjects from the Amsterdam cohort were interrogated at two time points for correlations between HIV-1 epitope mutation, antigen-specific T-cell expansion i.e. TCR diversity, and repertoire of responding CTL clonotypes. Data suggest continuous bidirectional adaptation between HIV-1 and HIV-specific T-cell clonotypes at the TCR-antigenic epitope interface.
• Viral epitope variation has no direct correlation with CTL repertoire and diversity, though parallel evolution of TCR repertoire, virus and CTL response was noted, independent of individual subjects. Different patterns of TCRβ evolution were observed in subjects who showed delayed progression to disease.
• Epitope A2-SL9, SLYNTVATL, was at 100% wild type sequence in most subjects at time point 1 (t₁). Variants were SLYNTiATL, pLYNTVATL, SLfNaVAvL, SLfNAVAvL, SLfNTVATL.

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.