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Displaying record number 55002

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HXB2 Location	Gag(147-155) p24(15-23) DNA(1228..1254)	Gag Epitope Map
Author Location	p24(15-23)
Epitope	ISPRTLNAW	Epitope Alignment
		Show epitope variants
Epitope Name	ISP
Species (MHC/HLA)	human(B*57:01)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, TCR usage, variant cross-reactivity, characterizing CD8+ T cells

Notes

• Functional cross-reactivity of CD8 responses to HIV-1 epitopes restricted by different HLA-alleles was analyzed. It was shown that epitope-specific responses with the most efficient cross-recognition were strongly associated with delayed disease progression. Variant-cross recognition efficiency was linked to the dominant TCRs used for epitope recognition. Epitopes restricted by the same HLA-allele did not show similar variant cross-recognition efficiency, suggesting that the rate of disease progression might be associated with the quality of responses to certain critical epitopes.
• This epitope, B57-ISP, is very strongly associated with delayed progression to AIDS, and its natural variants were less efficiently cross-recognized. Its alanine-substituted variants were poorly cross-recognized.

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.