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Displaying record number 54630

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HXB2 Location	Gag(170-187) p24(38-55) DNA(1297..1350)	Gag Epitope Map
Author Location	Gag
Epitope	PMFSALSEGATPQDLNTM	Epitope Alignment
		Show epitope variants
Epitope Name	GAG-24
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	China
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, immunodominance

Notes

• 46 ART-naive subjects with HIV-B infection were used to study CTL cross-responses between HIV clade B and C peptide sequences. 204/826 overlapping peptide epitopes tested were common between both clades in eliciting CTL responses that were of similar magnitude and frequency in both HIV-B and -C. Higher magnitudes and frequencies of responses were detected with peptides from Gag, Pol, Env and Nef proteins, while peptides from Rev, Vif, Vpu, Vpr and Tat were recognized less often.
• 27 peptides from immunodominant regions of higher inter-clade homology in Gag, Nef, Pol, Vpr, Env and Vif were found to be common between both clades in eliciting the greatest CTL responses. Although these 27 peptides differed by up to 39% between clades, CTL responsiveness was not affected.
• Cross-recognized peptides had a lower entropy of recognition than clade-B specific variants, suggesting that published conserved clade-B sequences are also more conserved between clades. Consensus sequences therefore occurred in virus regions of low intra-clade entropy and high inter-clade homology.
• 18/27 highly immunogenic clusters were previously reported by Frahm et al. [J. Virol. 78:2187-2200 (2004)].
• This peptide, PMFsALSEGATPQDLNTM differs from the consensus C sequence PMFtALSEGATPQDLNTM at 1 amino acid position, i.e. by 5.6%.

References

Zhao2007 Shuguang Zhao, Song Zhai, Yan Zhuang, Shaoyang Wang, Dedong Huang, Whenzhen Kang, Xinhong Li, Xu G. Yu, Bruce D. Walker, Marcus A. Altfeld, and Yongtao Sun. Inter-Clade Cross-Reactivity of HIV-1-Specific T Cell Responses in Human Immunodeficiency Virus Type 1 Infection in China. Curr. HIV Res., 5(2):251-259, Mar 2007. PubMed ID: 17346138. Show all entries for this paper.