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Displaying record number 53841

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HXB2 Location	Gag(28-36) p17(28-36) DNA(871..897)	Gag Epitope Map
Author Location	p17(28-36)
Epitope	KYKLKHIVW	Epitope Alignment
		Show epitope variants
Epitope Name	QW9
Species (MHC/HLA)	human(A*24)
Immunogen	HIV-1 infection
Patient MHC/HLA	M-1003: A*24, A*30, B*39, B*47, C*12, C*17; P-1189: A*23, A*24, B*07, B*39, C*12, C*17
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	responses in children, mother-to-infant transmission, escape, acute/early infection, viral fitness and reversion

Notes

• CD8 T-cell responses were examined in mother-infant pairs. Escape variants were commonly detected in maternal plasma. Early infant plasma viruses showed heterogeneity of gag and nef gene sequences as well as mother-to-child transmission of CD8 T-cell escape variants. The stability of escape mutants in the infant over time was determined by infant HLA haplotype and viral fitness.
• Sequential plasma specimens from infants showed changes in CD8 T-cell epitope sequences, suggesting that infants are capable of generating virus-specific CD8 T-cell responses.
• qYKLKHIVW is an escape variant of the A*24 epitope KYKLKHIVW, found in 9/10 clones from the mother (M-1003). It was transmitted to her infant (P-1189), and persisted for 15 months. Both the mother and child are A*24+.
• qYKLKHIVW elicted lower responder cell frequencies than KYKLKHIVW.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.