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Displaying record number 53745

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HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	Gag(169-177 SF2)
Epitope	EVIPMFSAL	Epitope Alignment
		Show epitope variants
Subtype	A, B, C, CRF01_AE, D
Species (MHC/HLA)	human(A*26:01, A*26:03)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Flow cytometric T-cell cytokine assay, HLA binding
Keywords	binding affinity, subtype comparisons, rate of progression, immunodominance, escape, HLA cross-presentation, variant cross-reactivity

Notes

• A*26 is associated with slow progression to disease and is common in Asian populations (about 20%). 31/110 HIV peptides that carried the A*2603 motif ([VTILP] at P2, [ML] at the C-terminus) bound to HLA-A*2603. Only 2 of these were epitopes and could induce specific CD8 T-cell responses in PBMC from HLA-A*2603 positive subjects.
• This epitope induced specific CD8+ T cells in chronically infected individuals with either A*2603 or A*2601. It is an immunodominant epitope.
• 3 common B clade variants were synthesized. EVIPMFaAL and EVIPMFtAL bound to A*2603 with equal affinity as the consensus form, EVIPMFSAL, but could not be recognized by an EVIPMFSAL-specific T-cell clone so may mediate TCR escape. The other common variant, kVIPMFSAL, did not bind to A*2603.
• EVIPMFSAL is the most common form in clades A, B, D, and E (CRF01), but EVIPMFtAL is the most common form in clade C.

References

Kawashima2005 Yuka Kawashima, Manami Satoh, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of HIV-1 Epitopes Presented by HLA-A*2603: Comparison Between HIV-1 Epitopes Presented by A*2601 and A*2603. Hum. Immunol., 66(11):1155-1166, Nov 2005. PubMed ID: 16571416. Show all entries for this paper.