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Displaying record number 53741

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HXB2 Location	Gag(162-172) p24(30-40) DNA(1273..1305)	Gag Epitope Map
Author Location	Gag
Epitope	KAFSPEVIPMF	Epitope Alignment
		Show epitope variants
Epitope Name	KAF
Species (MHC/HLA)	human(B57)
Immunogen	HIV-1 infection
Country	Netherlands
Experimental methods	Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	binding affinity, rate of progression, escape, characterizing CD8+ T cells

Notes

• HLA-B57 has been associated with long term non-progression in HIV+ people. The number and responsiveness of CD8 T-cells directed to different Gag peptides presented by HLA-A2, -B8 and B57 were compared. T cells specific for the HLA-B57 epitope KAFSPEVIPMF responded to a higher extent and more readily to antigenic stimulation than those specific for the A2 epitope SLYNTVATL and the B8 epitope EIYKRWII.
• Tetramer decay experiments indicate that the HLA-B57 peptide has a higher half-life than the A2 and B8 peptides. The authors point out that CD8+ T cells with high binding affinity may require less help.
• Variant forms of the HLA-B57 epitope KAFSPEVIPMF were found in the 3/5 HLA B57+ individuals sequenced, but the variants were always a minor form.

References

Jansen2005a Christine A. Jansen, Stefan Kostense, Kristin Vandenberghe, Nening M. Nanlohy, Iris M. De Cuyper, Erwan Piriou, Erik H. Manting, Frank Miedema, and Debbie van Baarle. High Responsiveness of HLA-B57-Restricted Gag-Specific CD8+ T Cells In Vitro May Contribute to the Protective Effect of HLA-B57 in HIV-Infection. Eur. J. Immunol., 35(1):150-158, Jan 2005. PubMed ID: 15593302. Show all entries for this paper.