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Displaying record number 53611

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HXB2 Location	Gag(21-35) p17(21-35) DNA(850..894)	Gag Epitope Map
Author Location	p17(24-31)
Epitope	LRPGGKKKYRLKHLV	Epitope Alignment
		Show epitope variants
Subtype	A, D
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A*66:01, A*68:01, B*53:01, B*58:02; A*30:02, A*68:01, B*57:03, B*58:02
Country	Uganda
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	subtype comparisons, variant cross-reactivity

Notes

• T-cell immune responses were examined in HIV-1 infected Ugandans. Similar levels of cross-clade responses for Gag, Env and Nef were observed. Higher frequencies of responses in conserved regions were found for Gag within a single clade, while areas with higher viral sequence variation had fewer detectable responses. Differential interclade sequence homologies between the Gag regions did not affect the respective level of cross-clade recognition.
• The sequence contains a known B8 epitope, but the subjects recognizing it were B8-negative. The autologous viral sequence was lrpggkkkyKlkhlv, and the peptide was recognized.

References

Barugahare2005 Banson Barugahare, Chris Baker, Okumu K'Aluoch, Richard Donovan, Mohamed Elrefaei, Mark Eggena, Norman Jones, Steven Mutalya, Cissy Kityo, Peter Mugyenyi, and Huyen Cao. Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition. J. Virol., 79(7):4132-4139, Apr 2005. PubMed ID: 15767414. Show all entries for this paper.