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Displaying record number 53418

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HXB2 Location	Tat(39-49) DNA(5945..5977)	Tat Epitope Map
Author Location	Tat(38-48)
Epitope	ITKGLGISYGR	Epitope Alignment
		Show epitope variants
Epitope Name	ITK
Species (MHC/HLA)	human(A*68:01)
Immunogen	HIV-1 infection
Patient MHC/HLA	A2, A68.1, B*07, B*35:03, C*04:01, C*07:02, DQ2, DQ6, DR15, DR17, DR51, DR52
Experimental methods	CD4 T-cell Elispot - IFNγ, CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, escape

Notes

• The increase in plasma viral load in a patient that progressed rapidly was preceded by positive selection of viral escape mutations in epitopes targeted by dominant HIV-1-specific CD8+ T-cell responses,and a decrease in HIV-1-specific CD4+ and CD8+ T-cell frequencies. Overall, escape variant epitopes were recognized 0-80% as efficiently as the index peptide, and the relatively efficiency of the variant epitopes increased using PBLs collected after their appearance. No changes were found in viral tropism, replication kinetics and neutralizing antibody titers, so the rapid decline of the patient was attributed to loss of HIV containment due to CTL escape.
• This was one of 8 reactive epitopes found not to vary over time.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.