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Displaying record number 53008

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HXB2 Location	Gag(77-85) p17(77-85) DNA(1018..1044)	Gag Epitope Map
Author Location
Epitope	SLYNTVATL	Epitope Alignment
		Show epitope variants
Epitope Name	SL9
Subtype	B
Species (MHC/HLA)	human(A*02:01)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, T-cell Elispot, Tetramer binding
Keywords	epitope processing, escape, variant cross-reactivity

Notes

• Epitope escape mutations in chronically infected individuals developed over several years indicating selective advantage of escape mutants. The maturation state of CTLs appear to affect the rate of epitope mutation and CTL decay.
• In two patients, SL9-specific CTL peaked at 2-4 years post-infection; at that point the escape mutations began to dominate followed by CTL decline with a 6 month lag, suggesting CTL decline resulted as a consequence of escape. In a third patient, the initial response was 1/2 as strong and mutations did not arise until 6-7 years post-infection; in that case the decline in SL9 CTL preceded epitope mutation.
• Two patients HLA-A*0201 started out with a non-consensus sequence, slFntvatl. In one of the patients, a transient reversion to the consensus was observed after 4 years, that did not reappear until the 11th year, suggesting the possibility that a reversion to the consensus form occurred, but a CTL response may have limited it so that this more fit form could not re-assert itself until the patient had a more severely compromised immune response.

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.