Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 447

Download this epitope record as JSON.

HXB2 Location	Pol(313-321) RT(158-166) DNA(3021..3047)	Pol Epitope Map
Author Location	RT(325-333 LAI)
Epitope	AIFQSSMTK	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(A3)
Immunogen	HIV-1 infection
Experimental methods
Keywords	subtype comparisons

Notes

• The consensus peptide of B and D clade viruses is AIFQSSMTK.
• The consensus peptide of a subset of As is AIFQASMTK and it is less able to stimulate the CTL clone.
• The consensus peptide of a subset of As is SIFQSSMTK and is as reactive as the originally defined epitope.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.