Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 169

Download this epitope record as JSON.

HXB2 Location	Gag(167-175) p24(35-43) DNA(1288..1314)	Gag Epitope Map
Author Location	p24(167-175 LAI)
Epitope	EVIPMFSAL	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(A*26:01)
Immunogen
Experimental methods
Keywords	subtype comparisons

Notes

• Identified as optimal epitope within Gag sequence AFSPEVIPMFSALSEGATPQ.
• Relatively conserved epitope within B clade and in other clades.
• Suspected binding motif for HLA-A26 includes T or V anchor at position 2, negative charge at position 1.
• C. Brander notes that this is an A*2601 epitope in the 1999 database.

References

Goulder1996b P. Goulder, C. Conlon, K. McIntyre, and A. McMichael. Identification of a Novel Human Leukogen Antigen A26-Restricted Epitope in a Conserved Region of Gag. AIDS, 10(12):1441-1443, 1996. This paper is correspondence briefly describing the identification and characterization of an immunodominant A26-CTL epitope in an asymptomatic HIV+ individual. PubMed ID: 8902082. Show all entries for this paper.