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Displaying record number 63092
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HXB2 Location |
Tat(39-47) DNA(5945..5971) |
Tat Epitope Map
|
Author Location |
Tat |
Epitope |
ITKGLGISH
|
Epitope Alignment
|
|
|
Show epitope variants
|
Subtype |
B |
Species
(MHC/HLA)
|
human |
Immunogen |
HIV-1 infection |
Patient MHC/HLA |
MM48: A*24, A*26, B*15, B*27, C*01, C*03 |
Country |
United Kingdom |
Experimental methods |
CD8 T-cell Elispot - IFNγ, Other, Peptide titration |
Keywords |
dynamics, escape, acute/early infection, autologous responses |
Notes
- Turnbull2009 analyzed the kinetics of the HIV-specific CD8+ T-cell response in 21 acutely infected subjects. The first responses peaked as early as 5 days, but were of limited epitope breadth. Responses of additional specificities expanded in subsequent waves, resulting in successive shifts in epitope immunodominance over time. The preferential expansion of CD8+ T cells recognizing a subset of epitopes in acute infection is documented, resulting in asynchronous immune responses, and suggest that the initial T-cell response may influence the efficiency of viral containment in early infection.
- Autologous variants ITKGLGISy, ITKGLdISy, & IkKGLGISy evolved to dominate the quasispacies, and were recognized less well than ITKGLGISH, the autologous index epitope determined with earliest available sample, by PBMCs from subject MM48 sampled at time points around the time of response decline, indicating escape. Dynamics of these responses are shown in Fig. 5 of Turnbull2009.
- Variant ITKGLGISy is a known optimal epitope and is nested within B cons peptide CFHCQVCFITKGLGISYGRK which elicited a T-cell response in patient MM48.
References
Turnbull2009
Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710.
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