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Displaying record number 63078
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HXB2 Location |
Tat(31-50) DNA(5921..5980) |
Tat Epitope Map
|
Author Location |
Tat |
Epitope |
CFHCQVCFITKGLGISYGRK
|
Epitope Alignment
|
|
|
Show epitope variants
|
Subtype |
B |
Species
(MHC/HLA)
|
human |
Immunogen |
HIV-1 infection |
Patient MHC/HLA |
MM39: A*02:01, A*03:01, B*15:01, B*35:01, C*03:03:01, C*04:01:01:01; MM48: A*24, A*26, B*15, B*27, C*01, C*03 |
Country |
United Kingdom |
Experimental methods |
CD8 T-cell Elispot - IFNγ, Other |
Keywords |
dynamics, escape, acute/early infection |
Notes
- Turnbull2009 analyzed the kinetics of the HIV-specific CD8+ T-cell response in 21 acutely infected subjects. The first responses peaked as early as 5 days, but were of limited epitope breadth. Responses of additional specificities expanded in subsequent waves, resulting in successive shifts in epitope immunodominance over time. The preferential expansion of CD8+ T cells recognizing a subset of epitopes in acute infection is documented, resulting in asynchronous immune responses, and suggesting that the initial T-cell response may influence the efficiency of viral containment in early infection.
- Yang2019 developed mathematical models of the Turnbull2009 dataset and determined that, in general, the relative CTL response breadth increased moderately during the first symptomatic month and then remained relatively stable through the first 400 days post-infection. Analysis also suggested slow expansion kinetics for most HIV-specific CTL responses and the presence of intra- and interclonal competition. Neither breadth of response nor immunodominance was correlated with viral load.
- B consensus Tat epitope CFHCQVCFITKGLGISYGRK elicited a CTL response in 1/14 patients (MM48) assessed for B cons peptides. Autologous variant HCQVCFIsKGLGISYGRK, with a 2 AA truncation at N-terminus, elicited a CTL response in patient MM39. The dynamics of these responses & peptide sequences are shown in Fig. S2-S3 of Yang2019.
- Analysis of the HIV-specific T-cell response in patient MM48 identified CFHCQVCFITKGLGISYGRK as 1/1 targets both in the first available PBMC sample after symptom onset & 1/8 targets throughout the entire study.
- Fig. 5 of Turnbull2009 suggests that mutational escape occurs within this peptide for patient MM48.
References
Turnbull2009
Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710.
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Yang2019
Yiding Yang and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8+ T-Cell Responses in Acute Infection. Microorganisms, 7(3), 4 Mar 2019. PubMed ID: 30836625.
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