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Displaying record number 62952
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HXB2 Location |
Env(213-232) gp120(213-232) DNA(6861..6920) |
Env Epitope Map
|
Author Location |
Env |
Epitope |
IPIHYCAPAGFAILKCNDKK
|
Epitope Alignment
|
|
|
Show epitope variants
|
Subtype |
B |
Species
(MHC/HLA)
|
human |
Immunogen |
HIV-1 infection |
Patient MHC/HLA |
MM43: A*02, A*02:01, B*40:01, B*55:01, C*03, C*03; MM48: A*24, A*26, B*15, B*27, C*01, C*03 |
Country |
United Kingdom |
Experimental methods |
CD8 T-cell Elispot - IFNγ, Other |
Keywords |
dynamics, acute/early infection, autologous responses |
Notes
- Turnbull2009 analyzed the kinetics of the HIV-specific CD8+ T-cell response in 21 acutely infected subjects. The first responses peaked as early as 5 days, but were of limited epitope breadth. Responses of additional specificities expanded in subsequent waves, resulting in successive shifts in epitope immunodominance over time. The preferential expansion of CD8+ T cells recognizing a subset of epitopes in acute infection is documented, resulting in asynchronous immune responses, and suggesting that the initial T-cell response may influence the efficiency of viral containment in early infection. Yang2019 developed mathematical models of the Turnbull2009 dataset and determined that, in general, the relative CTL response breadth increased moderately during the first symptomatic month and then remained relatively stable through the first 400 days post-infection. Analysis also suggested slow expansion kinetics for most HIV-specific CTL responses and the presence of intra- and interclonal competition. Neither breadth of response nor immunodominance was correlated with viral load.
- B consensus Env peptide IPIHYCAPAGFAILKCNDKK elicited a CTL response in 1/14 patients (MM48) assessed for B cons peptides. An additional patient (MM43) had a CTL response to autologous variant IPIHYCAPAGFAILKCNn with a 2 AA truncation, relative to B cons.
- Dynamics of these responses are shown in Fig. 3 of Turnbull2009 (with VL) & Fig. S1-S2 of Yang2019.
References
Turnbull2009
Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710.
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Yang2019
Yiding Yang and Vitaly V. Ganusov. Defining Kinetic Properties of HIV-Specific CD8+ T-Cell Responses in Acute Infection. Microorganisms, 7(3), 4 Mar 2019. PubMed ID: 30836625.
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