HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 19 matching records:

Displaying record number 61810

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location  
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA VID411: A*0201, B*0801, B*5101, Cw*0303, Cw*0701; VID415: A*0201, A*0301, B*0702, B*4402, Cw*0702; VID411: A*0201, B*0801, B*5101, Cw*0303, Cw*0701
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.


Displaying record number 61860

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location  
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Subtype B
Species (MHC/HLA) human(A*0201)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 53997

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location ( C consensus)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Subtype C
Species (MHC/HLA) human(A*0205)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 61769

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location RT(127-135)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Species (MHC/HLA) human(A*0206)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61859

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location  
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Subtype B
Species (MHC/HLA) human(A*0206)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 61547

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location RT(127-135)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name Pol YI9
Subtype B, CRF01_AE
Species (MHC/HLA) human(A*0206)
Immunogen HIV-1 infection
Patient MHC/HLA KI-648: A*0206
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords optimal epitope, chronic infection

Notes

References

Watanabe2013 Koji Watanabe, Hayato Murakoshi, Yoshiko Tamura, Madoka Koyanagi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Identification of Cross-Clade CTL Epitopes in HIV-1 Clade A/E-Infected Individuals by Using the Clade B Overlapping Peptides. Microbes Infect., 15(13):874-886, Nov 2013. PubMed ID: 23968885. Show all entries for this paper.


Displaying record number 60495

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol(282-290)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Species (MHC/HLA) human(A*11)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1307

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol(316-)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name Pol-316
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, supertype, computational epitope prediction, HLA cross-presentation

Notes

References

Altfeld2001 M. A. Altfeld, B. Livingston, N. Reshamwala, P. T. Nguyen, M. M. Addo, A. Shea, M. Newman, J. Fikes, J. Sidney, P. Wentworth, R. Chesnut, R. L. Eldridge, E. S. Rosenberg, G. K. Robbins, C. Brander, P. E. Sax, S. Boswell, T. Flynn, S. Buchbinder, P. J. Goulder, B. D. Walker, A. Sette, and S. A. Kalams. Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif. J. Virol., 75(3):1301-11, Feb 2001. URL: http://jvi.asm.org/cgi/content/full/75/3/1301. PubMed ID: 11152503. Show all entries for this paper.


Displaying record number 53579

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location RT(127-135)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, HLA binding
Keywords acute/early infection, optimal epitope

Notes

References

Altfeld2005a Marcus Altfeld, Todd M. Allen, Elizabeth T. Kalife, Nicole Frahm, Marylyn M. Addo, Bianca R. Mothe, Almas Rathod, Laura L. Reyor, Jason Harlow, Xu G. Yu, Beth Perkins, Loren K. Robinson, John Sidney, Galit Alter, Mathias Lichterfeld, Alessandro Sette, Eric S. Rosenberg, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. The Majority of Currently Circulating Human Immunodeficiency Virus Type 1 Clade B Viruses Fail To Prime Cytotoxic T-Lymphocyte Responses against an Otherwise Immunodominant HLA-A2-Restricted Epitope: Implications for Vaccine Design. J. Virol., 79(8):5000-5005, Apr 2005. PubMed ID: 15795285. Show all entries for this paper.


Displaying record number 54225

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location RT
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name A2-YI9(RT)
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 54516

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location RT
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name A2-YI9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Patient MHC/HLA A2, A68, B14, B44, Cw5, Cw8
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords rate of progression, escape, acute/early infection, co-receptor, mutation acquisition

Notes

References

Streeck2007 Hendrik Streeck, Becky Schweighardt, Heiko Jessen, Rachel L. Allgaier, Terri Wrin, Eric W. Stawiski, Arne B. Jessen, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Loss of HIV-1-Specific T-Cell Responses Associated with Very Rapid HIV-1 Disease Progression. AIDS, 21(7):889-891, 23 Apr 2007. PubMed ID: 17415054. Show all entries for this paper.


Displaying record number 55498

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location RT
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 55905

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location RT
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9(RT)
Subtype B
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 1585

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol(306-314)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Species (MHC/HLA) human(A2 supertype)
Immunogen HIV-1 infection
Experimental methods  
Keywords supertype, rate of progression

Notes

References

Propato2001 A. Propato, E. Schiaffella, E. Vicenzi, V. Francavilla, L. Baloni, M. Paroli, L. Finocchi, N. Tanigaki, S. Ghezzi, R. Ferrara, R. Chesnut, B. Livingston, A. Sette, R. Paganelli, F. Aiuti, G. Poli, and V. Barnaba. Spreading of HIV-specific CD8+ T-cell repertoire in long-term nonprogressors and its role in the control of viral load and disease activity. Hum. Immunol., 62(6):561-76, Jun 2001. PubMed ID: 11390031. Show all entries for this paper.


Displaying record number 60492

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol(282-290)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Species (MHC/HLA) human(A*66)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60494

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol(282-290)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60491

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol(282-290)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60493

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol(282-290)
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Epitope Name YI9
Species (MHC/HLA) human(C*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58075

HXB2 Location Pol(282-290)
RT(127-135)
DNA(2928..2954)
Pol Epitope Map
Author Location Pol
Epitope YTAFTIPSI Epitope Alignment
YTAFTIPSI epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type adenovirus type 5 (Ad5), DNA prime with Ad5 boost
Vaccine strain B clade IIIB, B clade JRFL, B clade CAM-1
Vaccine component Gag, Nef, Pol

Notes

References

Li2011a Fusheng Li, Adam C. Finnefrock, Sheri A. Dubey, Bette T. M. Korber, James Szinger, Suzanne Cole, M. Juliana McElrath, John W. Shiver, Danilo R. Casimiro, Lawrence Corey, and Steven G Self. Mapping HIV-1 Vaccine Induced T-Cell Responses: Bias Towards Less-Conserved Regions and Potential Impact on Vaccine Efficacy in the Step Study. PLoS One, 6(6):e20479, 2011. PubMed ID: 21695251. Show all entries for this paper.


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