HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 14 matching records:

Displaying record number 61468

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Epitope Name YV9
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage

Notes

References

Mummert2016 Christiane Mummert, Christian Hofmann, Angela G. Hückelhoven, Silke Bergmann, Sandra M. Mueller-Schmucker, Ellen G. Harrer, Jan Dörrie, Niels Schaft, and Thomas Harrer. T-Cell Receptor Transfer for Boosting HIV-1-Specific T-Cell Immunity in HIV-1-Infected Patients. AIDS, 30(14):2149-2158, 10 Sep 2016. PubMed ID: 27258398. Show all entries for this paper.


Displaying record number 61273

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country Mexico, Spain
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords drug resistance

Notes

References

Blanco-Heredia2016 Juan Blanco-Heredia, Aarón Lecanda, Humberto Valenzuela-Ponce, Christian Brander, Santiago Ávila-Rios, and Gustavo Reyes-Terán. Identification of Immunogenic Cytotoxic T Lymphocyte Epitopes Containing Drug Resistance Mutations in Antiretroviral Treatment-Naive HIV-Infected Individuals. PLoS One, 11(1):e0147571, 2016. PubMed ID: 26808823. Show all entries for this paper.


Displaying record number 58302

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT(181-189)
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Show epitope variants
Epitope Name YV9
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country France, Germany
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords variant cross-reactivity, HLA associated polymorphism, drug resistance

Notes

References

Pacheco2011 Yovana Pacheco, Clotilde Allavena, Yannick Guilloux, Sandra M. Mueller-Schmucker, Angela G. Hueckelhoven, Elisabeth André-Garnier, François Cleon, Virginie Ferré, Audrey Rodallec, Eric Billaud, Thomas Harrer, François Raffi, and Dorian McIlroy. The Immune Response to the RT181-189 Epitope in HIV-1-Infected Patients Is Associated with Viral Sequence Polymorphism Flanking the Epitope. J. Clin. Immunol., 31(4):681-689, Aug 2011. PubMed ID: 21491096. Show all entries for this paper.


Displaying record number 54573

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT(181-189)
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Subtype B
Species (MHC/HLA) human(A*02)
Immunogen HIV-1 infection
Country United States
Experimental methods Intracellular cytokine staining, Other
Keywords rate of progression, escape, mutation acquisition

Notes

References

Karlsson2007 Annika C. Karlsson, Astrid K. N. Iversen, Joan M. Chapman, Tulio de Oliviera, Gerald Spotts, Andrew J. McMichael, Miles P. Davenport, Frederick M. Hecht, and Douglas F. Nixon. Sequential Broadening of CTL Responses in Early HIV-1 Infection Is Associated with Viral Escape. PLoS ONE, 2:e225, 2007. PubMed ID: 17311088. Show all entries for this paper.


Displaying record number 61026

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT(181-189)
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Patient MHC/HLA 98621: A*02:01:01G, B*40:01:01G, B*44:02:01G, C*03:04:01G, C*05:01
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 61314

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location  
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Show epitope variants
Subtype A, B, C, D
Species (MHC/HLA) humanized mouse(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, vaccine antigen design

Vaccine Details

Vaccine type modified vaccinia Ankara (MVA), adenovirus
Vaccine strain A clade, B clade, other, C clade

Notes

References

Abdul-Jawad2016 Sultan Abdul-Jawad, Beatrice Ondondo, Andy van Hateren, Andrew Gardner, Tim Elliott, Bette Korber, and Tomáš Hanke. Increased Valency of Conserved-Mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition. Mol. Ther., 24(2):375-384, Feb 2016. PubMed ID: 26581160. Show all entries for this paper.


Displaying record number 61325

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location Pol
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Epitope Name YV9
Subtype A, B, C, D
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, immunodominance

Notes

References

Ahmed2016 Tina Ahmed, Nicola J. Borthwick, Jill Gilmour, Peter Hayes, Lucy Dorrell, and Tomáš Hanke. Control of HIV-1 Replication In Vitro by Vaccine-Induced Human CD8+ T Cells through Conserved Subdominant Pol Epitopes. Vaccine, 34(9):1215-1224, 24 Feb 2016. PubMed ID: 26784683. Show all entries for this paper.


Displaying record number 61828

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location  
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Epitope Name YV9
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection, vaccine
Patient MHC/HLA VID416: A*02:01, B*08:01, B*44:02, C*05:01, C*07:01
Country United Kingdom
Experimental methods Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses, optimal epitope

Notes

References

Borthwick2017 Nicola Borthwick, Zhansong Lin, Tomohiro Akahoshi, Anuska Llano, Sandra Silva-Arrieta, Tina Ahmed, Lucy Dorrell, Christian Brander, Hayato Murakoshi, Masafumi Takiguchi, and Tomáš Hanke. Novel, In-Natural-Infection Subdominant HIV-1 CD8+ T-Cell Epitopes Revealed in Human Recipients of Conserved-Region T-Cell Vaccines. PLoS One, 12(4):1-19, 2017. PubMed ID: 28448594. Show all entries for this paper.


Displaying record number 61871

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location  
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Epitope Name YV9
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 1469

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT(181-189 LAI)
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, computational epitope prediction

Notes

References

Samri2000 A. Samri, G. Haas, J. Duntze, J. M. Bouley, V. Calvez, C. Katlama, and B. Autran. Immunogenicity of mutations induced by nucleoside reverse transcriptase inhibitors for human immunodeficiency virus type 1-specific cytotoxic T cells. J. Virol., 74(19):9306-12, Oct 2000. URL: http://jvi.asm.org/cgi/content/full/74/19/9306. PubMed ID: 10982378. Show all entries for this paper.


Displaying record number 62747

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location  
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Epitope Name YQY
Species (MHC/HLA) human(A*02:01)
Immunogen vaccine
Country United Kingdom
Experimental methods Other, T-cell Elispot
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type non-replicating adenovirus, polyepitope, DNA prime with modified vaccinia Ankara (MVA) boost, other, HIVconsv, recombinant protein
Vaccine strain A clade, B clade, multiple epitope immunogen, C clade, D clade
Vaccine component Env, Gag, Pol, Vif, other

Notes

References

Borthwick2018 Nicola J. Borthwick, Thirusha Lane, Nathifa Moyo, Alison Crook, Jung Min Shim, Ian Baines, Edmund G. Wee, Philip N. Hawkins, Julian D. Gillmore, Tomáš Hanke, and Mark B. Pepys. Randomized Phase I Trial HIV-CORE 003: Depletion of Serum Amyloid P Component and Immunogenicity of DNA Vaccination Against HIV-1. PLoS One, 13(5):e0197299, 2018. PubMed ID: 29772028. Show all entries for this paper.


Displaying record number 54323

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT(181-189)
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 58847

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HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location RT
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Show epitope variants
Epitope Name YV9
Subtype B
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords HAART, ART, escape, optimal epitope, drug resistance

Notes

References

Vollbrecht2012 Thomas Vollbrecht, Josef Eberle, Julia Roider, Silja Bühler, Renate Stirner, Nadja Henrich, Ulrich Seybold, Johannes R. Bogner, and Rika Draenert. Control of M184V HIV-1 Mutants by CD8 T-Cell Responses. Med. Microbiol. Immunol., 201(2):201-211, May 2012. PubMed ID: 22200907. Show all entries for this paper.


Displaying record number 59371

Download this epitope record as JSON.

HXB2 Location Pol(336-344)
RT(181-189)
DNA(3090..3116)
Pol Epitope Map
Author Location  
Epitope YQYMDDLYV Epitope Alignment
YQYMDDLYV epitope logo
Epitope Name YV9
Species (MHC/HLA) human(A*02:01)
Immunogen HIV-1 infection
Patient MHC/HLA T32: A*02:01, A*25:01, B*44:02, C*05:01, C*07:04
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, optimal epitope

Notes

References

Roider2014 Julia Roider, Tim Meissner, Franziska Kraut, Thomas Vollbrecht, Renate Stirner, Johannes R. Bogner, and Rika Draenert. Comparison of Experimental Fine-Mapping to In Silico Prediction Results of HIV-1 Epitopes Reveals Ongoing Need for Mapping Experiments. Immunology, 143(2):193-201, Oct 2014. PubMed ID: 24724694. Show all entries for this paper.


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