Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 365

Download this epitope record as JSON.

HXB2 Location	Gag(484-493) p2p7p1p6(121-130) DNA(2239..2268)	Gag Epitope Map
Author Location	Gag(484-493)
Epitope	YPLTSLRSLF	Epitope Alignment
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

• This B7 epitope is one of three subdominant CTL responses detected in a long-term non-progressor.
• A dominant B7 epitope was defined using conventional methods, and three additional sub-dominant HLA B7 epitopes were defined by first using a non-anchor based strategy, EpiMatrix, to identify 2078 possible epitopes in the autologous HIV-1, followed by B7 anchor residue prediction to narrow the set to 55 peptides for experimental testing.

References

Jin2000 X. Jin, C. G. Roberts, D. F. Nixon, J. T. Safrit, L. Q. Zhang, Y. X. Huang, N. Bhardwaj, B. Jesdale, A. S. DeGroot, and R. A. Koup. Identification of Subdominant Cytotoxic T Lymphocyte Epitopes Encoded by Autologous HIV Type 1 Sequences, Using Dendritic Cell Stimulation and Computer-Driven Algorithm. AIDS Res. Hum. Retroviruses, 16:67-76, 2000. PubMed ID: 10628818. Show all entries for this paper.

Displaying record number 53914

Download this epitope record as JSON.

HXB2 Location	Gag(484-493) p2p7p1p6(121-130) DNA(2239..2268)	Gag Epitope Map
Author Location	Gag
Epitope	YPLTSLRSLF	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B7)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*03:01, A*23:01, B*07:02, B*15:03
Country	United States
Experimental methods
Keywords	escape, acute/early infection

Notes

• Full HIV genomes from nine individuals were analyzed for mutations prior to seroconversion and 7 to 28 days later. It was found that the influence of the host's HLA type was reflected within weeks of infection; a statistically significant number of early nonsynonymous mutations were observed within previously reported CTL epitopes.
• T to A mutation was observed in position 4, and R to K in position 7.

References

Bernardin2005 Flavien Bernardin, Denice Kong, Lorraine Peddada, Lee Ann Baxter-Lowe, and Eric Delwart. Human Immunodeficiency Virus Mutations During the First Month of Infection are Preferentially Found in Known Cytotoxic T-Lymphocyte Epitopes. J. Virol., 79(17):11523-11528, Sep 2005. PubMed ID: 16103205. Show all entries for this paper.