HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 33 matching records:

Displaying record number 60488

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name YY9
Species (MHC/HLA) human(A*23)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 59221

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name Nef 135-143
Subtype B
Species (MHC/HLA) human(B*07, B*35)
Immunogen vaccine
Country France
Experimental methods CD8 T-cell Elispot - IFNγ, Degranulation, CD107a and b cell surface mobilization, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses

Vaccine Details

Vaccine type lipopeptide

Notes

References

Figueiredo2014 Suzanne Figueiredo, Benedicte Charmeteau, Mathieu Surenaud, Dominique Salmon, Odile Launay, Jean-Gérard Guillet, Anne Hosmalin, and Hanne Gahery. Memory CD8+ T Cells Elicited by HIV-1 Lipopeptide Vaccines Display Similar Phenotypic Profiles but Differences in Term of Magnitude and Multifunctionality Compared with FLU- or EBV-Specific Memory T Cells in Humans. Vaccine, 32(4):492-501, 16 Jan 2014. PubMed ID: 24291199. Show all entries for this paper.


Displaying record number 1831

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 LAI)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen in vitro stimulation or selection
Experimental methods  
Keywords epitope processing

Notes

References

LucchiariHartz2000 M. Lucchiari-Hartz, P. M. van Endert, G. Lauvau, R. Maier, A. Meyerhans, D. Mann, K. Eichmann, and G. Niedermann. Cytotoxic T lymphocyte epitopes of HIV-1 Nef: Generation of multiple definitive major histocompatibility complex class I ligands by proteasomes. J. Exp. Med., 191(2):239-52, 17 Jan 2000. URL: http://www.jem.org/cgi/content/full/191/2/239. PubMed ID: 10637269. Show all entries for this paper.


Displaying record number 57984

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B*0702)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords acute/early infection

Notes

References

Arnoczy2011 Gretchen S. Arnoczy, Guido Ferrari, Nilu Goonetilleke, Tumena Corrah, Hui Li, Joann Kuruc, John L. Schmitz, Kara McGee, Charles Hicks, and Joseph J. Eron. Massive CD8 T Cell Response to Primary HIV Infection in the Setting of Severe Clinical Presentation. AIDS Res. Hum. Retroviruses, 19 Oct 2011. PubMed ID: 22011008. Show all entries for this paper.


Displaying record number 55196

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location  
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 53566

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Allen2005a Todd M. Allen, Marcus Altfeld, Shaun C. Geer, Elizabeth T. Kalife, Corey Moore, Kristin M. O'Sullivan, Ivna DeSouza, Margaret E. Feeney, Robert L. Eldridge, Erica L. Maier, Daniel E. Kaufmann, Matthew P. Lahaie, Laura Reyor, Giancarlo Tanzi, Mary N. Johnston, Christian Brander, Rika Draenert, Jurgen K. Rockstroh, Heiko Jessen, Eric S. Rosenberg, Simon A. Mallal, and Bruce D. Walker. Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution. J. Virol., 79(21):13239-13249, Nov 2005. PubMed ID: 16227247. Show all entries for this paper.


Displaying record number 55216

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location  
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 1070

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 LAI)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B18)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords  

Notes

References

Culmann1991 B. Culmann, E. Gomard, M.-P. Kieny, B. Guy, F. Dreyfus, A.-D. Saimot, D. Sereni, D. Sicard, and J.-P. Levy. Six Epitopes with Human Cytotoxic CD8+ Cells in the Central Region of the HIV-1 Nef Protein. J. Immunol., 146:1560-1565, 1991. Nef-specific CTL were generated from six seropositive donors. Six epitopes were defined, all localized to two regions in the central part of Nef. Some epitopes could be recognized in the contexts of several HLA class I molecules. Peptides were based on BRU epitopes: QVPLRPMTYK, HLA A3, A11, B35; AAVDLSHFLKEK, HLA A11; HTQGYFPQWQ, HLA B17;TQGYFPQWQNYT, HLA B17, B37, NYTPGPGVRYPLT, HLA B7; and GVRYPLTFGWCYKLVP, HLA B18). PubMed ID: 1704397. Show all entries for this paper.

CulmannPenciolelli1994 B. Culmann-Penciolelli, S. Lamhamedi-Cherradi, I. Couillin, N. Guegan, J. P. Levy, J. G. Guillet, and E. Gomard. Identification of multirestricted immunodominant regions recognized by cytolytic T lymphocytes in the human immunodeficiency virus type 1 Nef protein. J. Virol., 68:7336-43, 1994. See comments in J Virol 1995 Jan;69(1):618. PubMed ID: 7523699. Show all entries for this paper.


Displaying record number 1568

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 SF2)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 52279

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name B18-YY9(Nef)
Subtype B
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Patient MHC/HLA A30, A32, B18, B27
Experimental methods  
Keywords HAART, ART, supervised treatment interruptions (STI)

Notes

References

Altfeld2002 Marcus Altfeld, Jan van Lunzen, Nicole Frahm, Xu G. Yu, Claus Schneider, Robert L. Eldridge, Margaret E. Feeney, Dirk Meyer-Olson, Hans-Juergen Stellbrink, and Bruce D. Walker. Expansion of Pre-existing, Lymph Node-localized CD8+ T Cells During Supervised Treatment Interruptions in Chronic HIV-1 Infection. J. Clin. Invest., 109(6):837-843, Mar 2002. PubMed ID: 11901192. Show all entries for this paper.


Displaying record number 53486

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name YY9
Subtype B
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A2, B18, B44, Cw12, Cw5
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords  

Notes

References

Allen2005 Todd M. Allen, Xu G. Yu, Elizabeth T. Kalife, Laura L. Reyor, Mathias Lichterfeld, Mina John, Michael Cheng, Rachel L. Allgaier, Stanley Mui, Nicole Frahm, Galit Alter, Nancy V. Brown, Mary N. Johnston, Eric S. Rosenberg, Simon A. Mallal, Christian Brander, Bruce D. Walker, and Marcus Altfeld. De Novo Generation of Escape Variant-Specific CD8+ T-Cell Responses Following Cytotoxic T-Lymphocyte Escape in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(20):12952-12960, Oct 2005. PubMed ID: 16188997. Show all entries for this paper.


Displaying record number 53628

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B18, B35, B49, B53, B7)
Immunogen HIV-1 infection
Patient MHC/HLA A3, A31, B18, B39; A1, A3, B35, B8
Country United States
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Keywords HAART, ART, escape, variant cross-reactivity

Notes

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


Displaying record number 1679

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Show epitope variants
Species (MHC/HLA) human(B18, B49)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS), immunodominance

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 53737

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 BRU)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Show epitope variants
Subtype B, CRF02_AG
Species (MHC/HLA) human(B18, B53, B7)
Immunogen HIV-1 infection
Country Cote D'Ivoire
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons

Notes

References

Inwoley2005 André Inwoley, Patricia Recordon-Pinson, Marion Dupuis, Jessintha Gaston, Mathieu Genête, Albert Minga, Franck Letourneur, François Rouet, Jeannine Choppin, Hervé Fleury, Jean-Gérard Guillet, Muriel Andrieu, and ANRS 1220 PRIMO-CI Study Group. Cross-Clade Conservation of HIV Type 1 Nef Immunodominant Regions Recognized by CD8+ T Cells of HIV Type 1 CRF02\_AG-Infected Ivorian (West Africa). AIDS Res. Hum. Retroviruses, 21(7):620-628, Jul 2005. PubMed ID: 16060833. Show all entries for this paper.


Displaying record number 60487

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name YY9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1071

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 LAI)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B*1801)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 53600

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name YY9
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Patient MHC/HLA A*0201, A*0301, B*3501, B*51, Cw*04, Cw*06
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Intracellular cytokine staining
Keywords acute/early infection

Notes

References

Bansal2005a Anju Bansal, Ethan Gough, Steffanie Sabbaj, Doug Ritter, Karina Yusim, Greg Sfakianos, Grace Aldrovandi, Richard A. Kaslow, Craig M. Wilson, Mark J. Mulligan, J. Michael Kilby, and Paul A. Goepfert. CD8 T-Cell Responses in Early HIV-1 Infection Are Skewed Towards High Entropy Peptides. AIDS, 19(3):241-250, 18 Feb 2005. PubMed ID: 15718834. Show all entries for this paper.


Displaying record number 52256

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Patient MHC/HLA A11, A3, B35, B51
Experimental methods  
Keywords mother-to-infant transmission

Notes

References

Sabbaj2002a Steffanie Sabbaj, Bradley H. Edwards, Mrinal K. Ghosh, Katherine Semrau, Sanford Cheelo, Donald M. Thea, Louise Kuhn, G. Douglas Ritter, Mark J. Mulligan, Paul A. Goepfert, and Grace M. Aldrovandi. Human Immunodeficiency Virus-Specific CD8(+) T Cells in Human Breast Milk. J. Virol., 76(15):7365-7373, Aug 2002. PubMed ID: 12097549. Show all entries for this paper.


Displaying record number 54877

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location  
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 52133

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 BRU)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 1970

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name Nef-YY9
Subtype B
Species (MHC/HLA) human(B*35, B*5301)
Immunogen HIV-1 infection
Patient MHC/HLA 00RCH33: A*3002, A*3201, B*4501, B*5301, Cw*0401, Cw*1202
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords HAART, ART, novel epitope

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 58665

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name Nef YY9
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Barbados, Botswana, Haiti, Japan, Mexico, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords subtype comparisons, optimal epitope, novel epitope

Notes

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


Displaying record number 60486

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name YY9
Species (MHC/HLA) human(B*3501, B*3508)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60485

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name YY9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1069

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Show epitope variants
Species (MHC/HLA) human(B49)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords subtype comparisons, HIV exposed persistently seronegative (HEPS)

Notes

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


Displaying record number 1337

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location  
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B49)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001 R. Kaul, S. L. Rowland-Jones, J. Kimani, T. Dong, H. B. Yang, P. Kiama, T. Rostron, E. Njagi, J. J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Late Seroconversion in HIV-Resistant Nairobi Prostitutes Despite Pre-Existing HIV-Specific CD8+ Responses. J. Clin. Invest., 107(3):341-349, Feb 2001. URL: http://www.jci.org/cgi/content/full/107/3/341. PubMed ID: 11160158. Show all entries for this paper.


Displaying record number 57225

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B49)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords mother-to-infant transmission

Notes

References

Lohman-Payne2009 B. Lohman-Payne, J. A. Slyker, B. A. Richardson, C. Farquhar, M. Majiwa, E. Maleche-Obimbo, D. Mbori-Ngacha, J. Overbaugh, S. Rowland-Jones, and G. John-Stewart. Infants with Late Breast Milk Acquisition of HIV-1 Generate Interferon-gamma Responses More Rapidly than Infants with Early Peripartum Acquisition. Clin. Exp. Immunol., 156(3):511-517, Jun 2009. PubMed ID: 19438605. Show all entries for this paper.


Displaying record number 54376

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name B53-YY9(Nef)
Species (MHC/HLA) human(B53)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55058

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B*5301)
Immunogen HIV-1 infection
Country Kenya
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords subtype comparisons, HLA cross-presentation, variant cross-reactivity

Notes

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


Displaying record number 52595

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Species (MHC/HLA) human(B*5301)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 52132

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 BRU)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, epitope processing

Notes

References

Choppin2001 Jeannine Choppin, William Cohen, Albert Bianco, Jean-Paul Briand, Francine Connan, Marc Dalod, and Jean-Gérard Guillet. Characteristics of HIV-1 Nef Regions Containing Multiple CD8+ T Cell Epitopes: Wealth of HLA-Binding Motifs and Sensitivity to Proteasome Degradation. J. Immunol., 166(10):6164-6169, 15 May 2001. PubMed ID: 11342637. Show all entries for this paper.


Displaying record number 52951

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Subtype B
Species (MHC/HLA) human(B7 supertype)
Immunogen vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Proliferation
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type lipopeptide
Vaccine strain B clade LAI
Vaccine component Env, Gag, Nef
Adjuvant QS21

Notes

References

Gahery-Segard2003 Hanne Gahéry-Ségard, Gilles Pialoux, Suzanne Figueiredo, Céline Igéa, Mathieu Surenaud, Jessintha Gaston, Helene Gras-Masse, Jean-Paul Lévy, and Jean-Gérard Guillet. Long-Term Specific Immune Responses Induced in Humans by a Human Immunodeficiency Virus Type 1 Lipopeptide Vaccine: Characterization of CD8+-T-Cell Epitopes Recognized. J. Virol., 77(20):11220-11231, Oct 2003. PubMed ID: 14512570. Show all entries for this paper.


Displaying record number 61943

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCY Epitope Alignment
YPLTFGWCY epitope logo
Epitope Name YY9
Subtype B
Species (MHC/HLA) human(Cw*0702)
Immunogen HIV-1 infection
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Other
Keywords assay or method development, novel epitope

Notes

References

Stoll2015 Andrej Stoll, Silke Bergmann, Christiane Mummert, Sandra M. Mueller-Schmucker, Bernd M. Spriewald, Ellen G. Harrer, and Thomas Harrer. Identification of HLA-C Restricted, HIV-1-Specific CTL Epitopes by Peptide Induced Upregulation of HLA-C Expression. J. Immunol. Methods, 418:9-18, Mar 2015. PubMed ID: 25633660. Show all entries for this paper.


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