HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 35 matching records:

Displaying record number 52733

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location p17
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Species (MHC/HLA) human(A2)
Immunogen HIV-1 infection
Experimental methods Intracellular cytokine staining
Keywords immunodominance, genital and mucosal immunity

Notes

References

Kaul2003 Rupert Kaul, Paul Thottingal, Joshua Kimani, Peter Kiama, Charles W. Waigwa, Job J. Bwayo, Francis A. Plummer, and Sarah L. Rowland-Jones. Quantitative Ex Vivo Analysis of Functional Virus-Specific CD8 T Lymphocytes in the Blood and Genital Tract of HIV-Infected Women. AIDS, 17(8):1139-1144, May 2003. PubMed ID: 12819514. Show all entries for this paper.


Displaying record number 60479

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(A*23)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60480

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 57766

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype C
Species (MHC/HLA) human(B*0702, B*1801)
Immunogen HIV-1 infection
Patient MHC/HLA A*0301, A*3201, B*0702, B*4403, Cw*0210, Cw*0702; A*0301, A*8001, B*0801, B*1801, Cw*0202, Cw*0702
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.


Displaying record number 52198

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Species (MHC/HLA) human(B18)
Immunogen HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2002 Rupert Kaul, Sarah L. Rowland-Jones, Geraldine Gillespie, Joshua Kimani, Tao Dong, Peter Kiama, J. Neil Simonsen, Job J. Bwayo, Andrew J. McMichael, and Francis A. Plummer. Gonococcal Cervicitis is Associated with Reduced Systemic CD8+ T Cell Responses in Human Immunodeficiency Virus Type 1-Infected and Exposed, Uninfected Sex Workers. J. Infect. Dis., 185(10):1525-1529, 15 May 2002. PubMed ID: 11992292. Show all entries for this paper.


Displaying record number 1068

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef( subtype D)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype D
Species (MHC/HLA) human(B18)
Immunogen HIV-1 exposed seronegative
Experimental methods  
Keywords  

Notes

References

Kaul2000 R. Kaul, F. A. Plummer, J. Kimani, T. Dong, P. Kiama, T. Rostron, E. Njagi, K. S. MacDonald, J. J. Bwayo, A. J. McMichael, and S. L. Rowland-Jones. HIV-1-Specific Mucosal CD8+ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi. J. Immunol., 164:1602-1611, 2000. PubMed ID: 10640781. Show all entries for this paper.


Displaying record number 54524

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Show epitope variants
Epitope Name YF9
Subtype B
Species (MHC/HLA) human(B18, B35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, acute/early infection, assay or method development, mutation acquisition

Notes

References

Malhotra2007a Uma Malhotra, Fusheng Li, Jessica Nolin, Megan Allison, Hong Zhao, James I. Mullins, Steve Self, and M. Juliana McElrath. Enhanced Detection of Human Immunodeficiency Virus Type 1 (HIV-1) Nef-Specific T Cells Recognizing Multiple Variants in Early HIV-1 Infection. J. Virol., 81(10):5225-5237, May 2007. PubMed ID: 17329342. Show all entries for this paper.


Displaying record number 56238

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location  
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype C
Species (MHC/HLA) human(B*5301, B18, B35)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression, immunodominance

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 53295

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location ( C consensus)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype C
Species (MHC/HLA) human(B*5301, B18)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA cross-presentation, characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 60478

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54081

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location ( C consensus)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype C
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 55829

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Subtype B
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords immunodominance

Notes

References

Cao2008 Jianhong Cao, John McNevin, Matthew McSweyn, Yi Liu, James I. Mullins, and M. Juliana McElrath. Novel Cytotoxic T-Lymphocyte Escape Mutation by a Three-Amino-Acid Insertion in the Human Immunodeficiency Virus Type 1 p6Pol and p6Gag Late Domain Associated with Drug Resistance. J. Virol., 82(1):495-502, Jan 2008. PubMed ID: 17942528. Show all entries for this paper.


Displaying record number 58540

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype B
Species (MHC/HLA) human(B*18, B*35)
Immunogen HIV-1 infection
Country Canada
Experimental methods Other
Keywords characterizing CD8+ T cells, elite controllers

Notes

References

Peretz2011 Yoav Peretz, Olivia Marra, Réjean Thomas, Danielle Legault, Pierre Côté, Mohamed-Rachid Boulassel, Danielle Rouleau, Jean-Pierre Routy, Rafick-Pierre Sékaly, Christos M Tsoukas, Cécile Tremblay, and Nicole F. Bernard. Relative Contribution of HIV-Specific Functional Lymphocyte Subsets Restricted by Protective and Non-Protective HLA Alleles. Viral Immunol, 24(3):189-198, Jun 2011. PubMed ID: 21668360. Show all entries for this paper.


Displaying record number 59080

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype B
Species (MHC/HLA) human(B*1801)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion

Notes

References

Liu2007a Yi Liu, John McNevin, Hong Zhao, Denis M. Tebit, Ryan M. Troyer, Matthew McSweyn, Ananta K. Ghosh, Daniel Shriner, Eric J. Arts, M. Juliana McElrath, and James I. Mullins. Evolution of Human Immunodeficiency Virus Type 1 Cytotoxic T-Lymphocyte Epitopes: Fitness-Balanced Escape. J. Virol., 81(22):12179-12188, Nov 2007. PubMed ID: 17728222. Show all entries for this paper.


Displaying record number 54169

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143 HXB2)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Subtype B
Species (MHC/HLA) human(B*1801)
Immunogen HIV-1 infection
Patient MHC/HLA PIC1362: A*0201, A*2501, B*1801, B*5101, Cw*0102, Cw*1203
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape, mutation acquisition, optimal epitope

Notes

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


Displaying record number 1067

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(139-147 SF2)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Shiga1996 H. Shiga, T. Shioda, H. Tomiyama, Y. Takamiya, S. Oka, S. Kimura, Y. Yamaguchi, T. Gojoubori, H. G. Rammensee, K. Miwa, and M. Takiguchi. Identification of Multiple HIV-1 Cytotoxic T Cell Epitopes Presented by Human Leukocyte Antigen B35 Molecule. AIDS, 10:1075-1083, 1996. PubMed ID: 8874623. Show all entries for this paper.


Displaying record number 56606

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Subtype C
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country South Africa, Zambia
Experimental methods  
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Goepfert2008 Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J. R. Goulder, and Eric Hunter. Transmission of HIV-1 Gag Immune Escape Mutations Is Associated with Reduced Viral Load in Linked Recipients. J. Exp. Med., 205(5):1009-1017, 12 May 2008. PubMed ID: 18426987. Show all entries for this paper.


Displaying record number 59400

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Patient MHC/HLA LTNP/EC-17: A*11, A*24, B*35, B*38, Cw*04, Cw*12
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, immunodominance

Notes

References

Migueles2015 Stephen A. Migueles, Daniel Mendoza, Matthew G. Zimmerman, Kelly M. Martins, Sushila A. Toulmin, Elizabeth P. Kelly, Bennett A. Peterson, Sarah A. Johnson, Eric Galson, Kate O. Poropatich, Andy Patamawenu, Hiromi Imamichi, Alexander Ober, Catherine A. Rehm, Sara Jones, Claire W. Hallahan, Dean A. Follmann, and Mark Connors. CD8+ T-Cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types. EBioMedicine, 2(1):46-58, Jan 2015. PubMed ID: 26137533. Show all entries for this paper.


Displaying record number 57803

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction, HLA associated polymorphism

Notes

References

Almeida2011 Coral-Ann M. Almeida, Corine Bronke, Steven G. Roberts, Elizabeth McKinnon, Niamh M. Keane, Abha Chopra, Carl Kadie, Jonathan Carlson, David W. Haas, Sharon A. Riddler, Richard Haubrich, David Heckerman, Simon Mallal, and Mina John. Translation of HLA-HIV Associations to the Cellular Level: HIV Adapts to Inflate CD8 T Cell Responses against Nef and HLA-Adapted Variant Epitopes. J. Immunol., 187(5):2502-2513, 1 Sep 2011. PubMed ID: 21821798. Show all entries for this paper.


Displaying record number 53875

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Patient MHC/HLA A*03, A*24, B*35, B*40
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection, variant cross-reactivity, superinfection

Notes

References

Yang2005 Otto O. Yang, Eric S. Daar, Beth D. Jamieson, Arumugam Balamurugan, Davey M. Smith, Jacqueline A. Pitt, Christos J. Petropoulos, Douglas D. Richman, Susan J. Little, and Andrew J. Leigh Brown. Human Immunodeficiency Virus Type 1 Clade B Superinfection: Evidence for Differential Immune Containment of Distinct Clade B Strains. J. Virol., 79(2):860-868, Jan 2005. PubMed ID: 15613314. Show all entries for this paper.


Displaying record number 54082

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location ( C consensus)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype C
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 61890

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Show epitope variants
Epitope Name YF9
Subtype B
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Patient MHC/HLA KI-642: B*3501
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords escape, HLA associated polymorphism

Notes

References

Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.


Displaying record number 58664

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name Nef YF9
Subtype C
Species (MHC/HLA) human(B*3501)
Immunogen HIV-1 infection
Country Barbados, Botswana, Haiti, Japan, Mexico, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords subtype comparisons, optimal epitope, novel epitope

Notes

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


Displaying record number 56485

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype C
Species (MHC/HLA) human(B*3501, B*5301)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords viral fitness and reversion, HLA associated polymorphism

Notes

References

Matthews2008 Philippa C. Matthews, Andrew Prendergast, Alasdair Leslie, Hayley Crawford, Rebecca Payne, Christine Rousseau, Morgane Rolland, Isobella Honeyborne, Jonathan Carlson, Carl Kadie, Christian Brander, Karen Bishop, Nonkululeko Mlotshwa, James I. Mullins, Hoosen Coovadia, Thumbi Ndung'u, Bruce D. Walker, David Heckerman, and Philip J. R. Goulder. Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point. J. Virol., 82(17):8548-8559, Sep 2008. PubMed ID: 18596105. Show all entries for this paper.


Displaying record number 60481

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(B*3502, B*3503, B*5301)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 52594

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Species (MHC/HLA) human(B53)
Immunogen  
Experimental methods  
Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 62127

HXB2 Location Nef(135-143) Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name B*53-YF9
Species (MHC/HLA) human(B*53)
Immunogen computer prediction
Country Argentina
Experimental methods Other, Relative replication capacity assay
Keywords binding affinity, structure, assay or method development, contact residues

Notes

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


Displaying record number 56414

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Subtype B
Species (MHC/HLA) human(B*53)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 61025

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype B
Species (MHC/HLA) human(B*5301)
Immunogen HIV-1 infection
Patient MHC/HLA 51314: A*0301, A*1101, B*3503, B*5301, Cw*0401, Cw*0401
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords acute/early infection

Notes

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.


Displaying record number 54080

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location ( C consensus)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Subtype C
Species (MHC/HLA) human(B*5301)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 60482

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60484

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(B*5801)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 56096

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name Nef1127
Subtype B
Species (MHC/HLA) human(B7)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, computational epitope prediction, HLA associated polymorphism

Notes

References

DeGroot2008 Anne S. De Groot, Daniel S. Rivera, Julie A. McMurry, Soren Buus, and William Martin. Identification of Immunogenic HLA-B7 ``Achilles' Heel'' Epitopes within Highly Conserved Regions of HIV. Vaccine, 26(24):3059-3071, 6 Jun 2008. PubMed ID: 18206276. Show all entries for this paper.


Displaying record number 60483

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(C*02)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60477

HXB2 Location Nef(135-143)
DNA(9199..9225)
Nef Epitope Map
Author Location Nef(135-143)
Epitope YPLTFGWCF Epitope Alignment
YPLTFGWCF epitope logo
Epitope Name YF9
Species (MHC/HLA) human(C*04)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


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