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Displaying record number 844

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HXB2 Location	gp160(586-593) gp41(75-82) DNA(7980..8003)	gp160 Epitope Map
Author Location	gp41
Epitope	YLQDQARL	Epitope Alignment
Subtype	HIV-2
Species (MHC/HLA)	human(B*08)
Immunogen	HIV-2 infection
Country	Gambia, Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	HIV exposed persistently seronegative (HEPS), HIV-2

Notes

• CTL responses in seronegative highly HIV-exposed African female sex workers in Gambia and Nairobi were studied -- these women had no delta 32 deletion in CCR5.
• In Gambia there is exposure to both HIV-1 and HIV-2. CTL responses to B*35 epitopes in exposed, uninfected women are cross-reactive.
• This HIV-2 sequence, YLQDQARL showed no cross-reactivity to HIV-1. Johnson1992
• Database note: First author "Rowland-Jones" is also found as "RowlandJones" on annotated papers in this database.

References

Johnson1992 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Identification of Overlapping HLA Class I-Restricted Cytotoxic T Cell Epitopes in a Conserved Region of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Definition of Minimum Epitopes and Analysis of the Effects of Sequence Variation. J. Exp. Med., 175:961-971, 1992. Fine mapping and mutational analysis of gp41 epitopes: ERYLKDQQL, HLA B14 and YLKDQQLL, HLA B8. PubMed ID: 1372650. Show all entries for this paper.

Rowland-Jones1999 S. L. Rowland-Jones, T. Dong, L. Dorrell, G. Ogg, P. Hansasuta, P. Krausa, J. Kimani, S. Sabally, K. Ariyoshi, J. Oyugi, K. S. MacDonald, J. Bwayo, H. Whittle, F. A. Plummer, and A. J. McMichael. Broadly Cross-Reactive HIV-Specific Cytotoxic T Lymphocytes in Highly-Exposed Persistently Seronegative Donors. Immunol. Lett., 66:9-14, 1999. PubMed ID: 10203028. Show all entries for this paper.