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Displaying record number 1072

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HXB2 Location	Nef(135-143) DNA(9199..9225)	Nef Epitope Map
Author Location	Nef( subtype B)
Epitope	YLPTFGWCY	Epitope Alignment
		Show epitope variants
Subtype	B
Species (MHC/HLA)	human(B49)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords	subtype comparisons

Notes

• HIV-specific CTL were found in exposed seronegative prostitutes from Nairobi -- these CTL may confer protection.
• Seroprevalence in this cohort is 90-95% and their HIV-1 exposure is among the highest in the world.
• Most isolated HIV strains are clade A in Nairobi, although clades C and D are also found -- B clade epitopes are often cross-reactive, however stronger responses are frequently observed using A or D clade versions of epitopes.
• This epitope is conserved among A and B clade viruses.
• The Clade D version of the epitope, YPLTFGWCF, was preferentially recognized by CTL.
• Database note: First author "Rowland-Jones" is also found as "RowlandJones" on annotated papers in this database.

References

Rowland-Jones1998 S. L. Rowland-Jones, T. Dong, K. R. Fowke, J. Kimani, P. Krausa, H. Newell, T. Blanchard, K. Ariyoshi, J. Oyugi, E. Ngugi, J. Bwayo, K. S. MacDonald, A. J. McMichael, and F. A. Plummer. Cytotoxic T cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J. Clin. Invest., 102(9):1758-65, 1 Nov 1998. PubMed ID: 9802890. Show all entries for this paper.