HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 22 matching records:

Displaying record number 60471

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location Env(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Epitope Name YL8
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 1757

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(580-587 CM243 subtype CRF01)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Show epitope variants
Subtype CRF01_AE
Species (MHC/HLA) human(A*24)
Immunogen HIV-1 infection
Experimental methods  
Keywords subtype comparisons

Notes

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1503

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(586-593 LAI)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Epitope Name E1
Subtype B
Species (MHC/HLA) human(A*24, B*08)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART

Notes

References

Mollet2000 L. Mollet, T. S. Li, A. Samri, C. Tournay, R. Tubiana, V. Calvez, P. Debre, C. Katlama, and B. Autran. Dynamics of HIV-specific CD8+ T lymphocytes with changes in viral load. J. Immunol., 165(3):1692-704, 1 Aug 2000. URL: http://www.jimmunol.org/v165n3/1692/1692-abs-frame.html. PubMed ID: 10903781. Show all entries for this paper.


Displaying record number 53028

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(591-598)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Subtype B
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, CD8 T-cell Elispot granzyme B
Keywords Th1, characterizing CD8+ T cells

Notes

References

Kleen2004 Thomas O. Kleen, Robert Asaad, Samuel J. Landry, Bernhard O. Boehm, and Magdalena Tary-Lehmann. Tc1 Effector Diversity Shows Dissociated Expression of Granzyme B and Interferon-gamma in HIV Infection. AIDS, 18(3):383-392, 20 Feb 2004. PubMed ID: 15090789. Show all entries for this paper.


Displaying record number 54266

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Epitope Name A24-YL8(gp41)
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 55934

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Epitope Name RL9(gp41)
Subtype B
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 55024

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location  
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(A24)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 52431

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41( subtype A)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Subtype A
Species (MHC/HLA) human, macaque(A24, B8)
Immunogen HIV-1 infection, vaccine
Experimental methods  
Keywords subtype comparisons, epitope processing, vaccine-induced immune responses, immunodominance

Vaccine Details

Vaccine type DNA prime with modified vaccinia Ankara (MVA) boost
Vaccine strain A clade
Vaccine component p17 Gag, p24 Gag

Notes

References

Hanke2000 Tomas Hanke and Andrew J. McMichael. Design and construction of an experimental HIV-1 vaccine for a year-2000 clinical trial in Kenya. Nat. Med., 6(9):951-955, Sep 2000. PubMed ID: 10973301. Show all entries for this paper.

Wee2002 Edmund G.-T. Wee, Sandip Patel, Andrew J. McMichael, and Tomáš Hanke. A DNA/MVA-Based Candidate Human Immunodeficiency Virus Vaccine for Kenya Induces Multi-Specific T Cell Responses in Rhesus Macaques. J. Gen. Virol., 83(Pt 1):75-80, Jan 2002. PubMed ID: 11752703. Show all entries for this paper.


Displaying record number 58222

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp160( LAI)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Subtype B
Species (MHC/HLA) human(A24, B8)
Immunogen HIV-1 infection
Experimental methods Chromium-release assay
Keywords immunodominance

Notes

References

Shankar1996 P. Shankar, J. A. Fabry, D. M. Fong, and J. Lieberman. Three Regions of HIV-1 gp160 Contain Clusters of Immunodominant CTL Epitopes. Immunol. Lett., 52:23-30, 1996. PubMed ID: 8877415. Show all entries for this paper.


Displaying record number 843

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(584-591 NL43)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(A*2402)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Dai1992 L. C. Dai, K. West, R. Littaua, K. Takahashi, and F. A. Ennis. Mutation of Human Immunodeficiency Virus Type 1 at Amino Acid 585 on gp41 Results in Loss of Killing by CD8+ A24-Restricted Cytotoxic T Lymphocytes. J. Virol., 66:3151-3154, 1992. An A24-restricted CD8+ CTL gp41 epitope was localized: YLKDQQLL, using a CTL clone from an HIV infected individual. Lys to (Arg or Gln) substitution in peptides used to pulse a target cell line eliminated killing. PubMed ID: 1373204. Show all entries for this paper.


Displaying record number 1797

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Day2001 C. L. Day, A. K. Shea, M. A. Altfeld, D. P. Olson, S. P. Buchbinder, F. M. Hecht, E. S. Rosenberg, B. D. Walker, and S. A. Kalams. Relative dominance of epitope-specific cytotoxic T-lymphocyte responses in human immunodeficiency virus type 1-infected persons with shared HLA alleles. J. Virol., 75(14):6279-91, Jul 2001. URL: http://jvi.asm.org/cgi/content/full/75/14/6279. PubMed ID: 11413294. Show all entries for this paper.


Displaying record number 62208

HXB2 Location gp160(586-593)
gp41(75-82)
gp160 Epitope Map
Author Location gp41(75-82)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Epitope Name YL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection, vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, therapeutic vaccine

Vaccine Details

Vaccine type DNA prime with Ad5 boost
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol

Notes

References

Casazza2013 Joseph P. Casazza, Kathryn A. Bowman, Selorm Adzaku, Emily C. Smith, Mary E. Enama, Robert T. Bailer, David A. Price, Emma Gostick, Ingelise J. Gordon, David R. Ambrozak, Martha C. Nason, Mario Roederer, Charla A. Andrews, Frank M. Maldarelli, Ann Wiegand, Mary F. Kearney, Deborah Persaud, Carrie Ziemniak, Raphael Gottardo, Julie E. Ledgerwood, Barney S. Graham, Richard A. Koup, and VRC 101 Study Team. Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire. J. Infect. Dis., 207(12):1829-1840, 15 Jun 2013. PubMed ID: 23482645. Show all entries for this paper.


Displaying record number 55560

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp160(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Show epitope variants
Epitope Name YL8
Subtype B
Species (MHC/HLA) human(B*08)
Immunogen HIV-1 infection
Patient MHC/HLA A1, A*6801, B51, B8, Cw15, Cw7, DQ2, DQ3, DR3, DR4
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, escape, mutation acquisition

Notes

References

Kemal2008 Kimdar Sherefa Kemal, Tara Beattie, Tao Dong, Barbara Weiser, Rupert Kaul, Carla Kuiken, Julian Sutton, Dorothy Lang, Hongbing Yang, Yan Chun Peng, Ronald Collman, Sean Philpott, Sarah Rowland-Jones, and Harold Burger. Transition from Long-Term Nonprogression to HIV-1 Disease Associated with Escape from Cellular Immune Control. J. Acquir. Immune Defic. Syndr., 48(2):119-126, 1 Jun 2008. PubMed ID: 18520675. Show all entries for this paper.


Displaying record number 53823

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Show epitope variants
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Patient MHC/HLA A*0101, A*0301, B*0801, B*5101; A*0101, B*0801
Country United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords escape, acute/early infection, variant cross-reactivity

Notes

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


Displaying record number 840

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(B*0801)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 57088

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(75-82 DU422)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Subtype B
Species (MHC/HLA) human(B*0801)
Immunogen in vitro stimulation or selection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Tetramer binding
Keywords dendritic cells

Notes

References

Colleton2009 Bonnie A. Colleton, Xiao-Li Huang, Nada M. Melhem, Zheng Fan, Luann Borowski, Giovanna Rappocciolo, and Charles R. Rinaldo. Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol., 83(12):6288-6299, Jun 2009. PubMed ID: 19357176. Show all entries for this paper.


Displaying record number 53754

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location Env(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Show epitope variants
Epitope Name YL8
Subtype B
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Patient MHC/HLA A*01, A*11, B*08, B*15, Cw*04, Cw*07
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Flow cytometric T-cell cytokine assay
Keywords escape, characterizing CD8+ T cells, optimal epitope

Notes

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 841

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(B8)
Immunogen peptide-HLA interaction
Experimental methods  
Keywords  

Notes

References

Sutton1993 J. Sutton, S. Rowland-Jones, W. Rosenberg, D. Nixon, F. Gotch, X.-M. Gao, N. Murray, A. Spoonas, P. Driscoll, M. Smith, A. Willis, and A. McMichael. A Sequence Pattern for Peptides Presented to Cytotoxic T Lymphocytes by HLA B8 Revealed by Analysis of Epitopes and Eluted Peptides. Eur. J. Immunol., 23:447-453, 1993. PubMed ID: 7679646. Show all entries for this paper.


Displaying record number 842

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(76-83)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(B8)
Immunogen  
Experimental methods  
Keywords  

Notes

References

Goulder1997c P. J. R. Goulder, S. W. Reid, D. A. Price, C. A. O'Callaghan, A. J. McMichael, R. E. Phillips, and E. Y. Jones. Combined Structural and Immunological Refinement of HIV-1 HLA-B8 Restricted Cytotoxic T Lymphocyte Epitopes. Eur. J. Immunol., 27:1515-1521, 1997. PubMed ID: 9209505. Show all entries for this paper.


Displaying record number 1673

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 exposed seronegative, HIV-1 infection
Experimental methods  
Keywords HIV exposed persistently seronegative (HEPS)

Notes

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 839

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location gp41(586-593)
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) human(B8)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Johnson1992 R. P. Johnson, A. Trocha, T. M. Buchanan, and B. D. Walker. Identification of Overlapping HLA Class I-Restricted Cytotoxic T Cell Epitopes in a Conserved Region of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Definition of Minimum Epitopes and Analysis of the Effects of Sequence Variation. J. Exp. Med., 175:961-971, 1992. Fine mapping and mutational analysis of gp41 epitopes: ERYLKDQQL, HLA B14 and YLKDQQLL, HLA B8. PubMed ID: 1372650. Show all entries for this paper.


Displaying record number 54813

HXB2 Location gp160(586-593)
gp41(75-82)
DNA(7980..8003)
gp160 Epitope Map
Author Location  
Epitope YLKDQQLL Epitope Alignment
YLKDQQLL epitope logo
Species (MHC/HLA) (B8)
Immunogen  
Experimental methods  
Keywords review, immunodominance, escape, vaccine antigen design

Notes

References

Altfeld2006a Marcus Altfeld and Todd M. Allen. Hitting HIV Where It Hurts: An Alternative Approach to HIV Vaccine Design. Trends Immunol., 27(11):504-510, Nov 2006. PubMed ID: 16997629. Show all entries for this paper.


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