HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 39 matching records:

Displaying record number 61619

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name Nef A01-YT9
Subtype B
Species (MHC/HLA) human(A*01)
Immunogen HIV-1 infection
Patient MHC/HLA 9213: A*01, A*24, B*38, B*44, Cw*04
Country Germany, Switzerland, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords escape, acute/early infection

Notes

References

Henn2012 Matthew R. Henn, Christian L. Boutwell, Patrick Charlebois, Niall J. Lennon, Karen A. Power, Alexander R. Macalalad, Aaron M. Berlin, Christine M. Malboeuf, Elizabeth M. Ryan, Sante Gnerre, Michael C. Zody, Rachel L. Erlich, Lisa M. Green, Andrew Berical, Yaoyu Wang, Monica Casali, Hendrik Streeck, Allyson K. Bloom, Tim Dudek, Damien Tully, Ruchi Newman, Karen L. Axten, Adrianne D. Gladden, Laura Battis, Michael Kemper, Qiandong Zeng, Terrance P. Shea, Sharvari Gujja, Carmen Zedlack, Olivier Gasser, Christian Brander, Christoph Hess, Huldrych F. Günthard, Zabrina L. Brumme, Chanson J. Brumme, Suzane Bazner, Jenna Rychert, Jake P. Tinsley, Ken H. Mayer, Eric Rosenberg, Florencia Pereyra, Joshua Z. Levin, Sarah K. Young, Heiko Jessen, Marcus Altfeld, Bruce W. Birren, Bruce D. Walker, and Todd M. Allen. Whole Genome Deep Sequencing of HIV-1 Reveals the Impact of Early Minor Variants Upon Immune Recognition During Acute Infection. PLoS Pathog., 8(3):e1002529, 2012. PubMed ID: 22412369. Show all entries for this paper.


Displaying record number 56233

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location  
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Subtype C
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 1529

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(118-126 SF2)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Experimental methods  
Keywords HAART, ART, acute/early infection

Notes

References

Altfeld2001b M. Altfeld, E. S. Rosenberg, R. Shankarappa, J. S. Mukherjee, F. M. Hecht, R. L. Eldridge, M. M. Addo, S. H. Poon, M. N. Phillips, G. K. Robbins, P. E. Sax, S. Boswell, J. O. Kahn, C. Brander, P. J. Goulder, J. A. Levy, J. I. Mullins, and B. D. Walker. Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection. J. Exp. Med., 193(2):169-80, 15 Jan 2001. URL: http://www.jem.org/cgi/content/full/193/2/169. PubMed ID: 11148221. Show all entries for this paper.


Displaying record number 54221

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name A1-YT9(Nef)
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, immunodominance, early-expressed proteins

Notes

References

Altfeld2006 Marcus Altfeld, Elizabeth T. Kalife, Ying Qi, Hendrik Streeck, Mathias Lichterfeld, Mary N. Johnston, Nicole Burgett, Martha E. Swartz, Amy Yang, Galit Alter, Xu G. Yu, Angela Meier, Juergen K. Rockstroh, Todd M. Allen, Heiko Jessen, Eric S. Rosenberg, Mary Carrington, and Bruce D. Walker. HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8+ T Cell Response against HIV-1. PLoS Med., 3(10):e403, Oct 2006. PubMed ID: 17076553. Show all entries for this paper.


Displaying record number 57825

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Subtype B
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, TCR binding
Keywords rate of progression, TCR usage, optimal epitope

Notes

References

Berger2011 Christoph T. Berger, Nicole Frahm, David A. Price, Beatriz Mothe, Musie Ghebremichael, Kari L. Hartman, Leah M. Henry, Jason M. Brenchley, Laura E. Ruff, Vanessa Venturi, Florencia Pereyra, John Sidney, Alessandro Sette, Daniel C. Douek, Bruce D. Walker, Daniel E. Kaufmann, and Christian Brander. High-Functional-Avidity Cytotoxic T Lymphocyte Responses to HLA-B-Restricted Gag-Derived Epitopes Associated with Relative HIV Control. J. Virol., 85(18):9334-9345, Sep 2011. PubMed ID: 21752903. Show all entries for this paper.


Displaying record number 55011

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location  
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, optimal epitope

Notes

References

Bihl2006 Florian Bihl, Nicole Frahm, Loriana Di Giammarino, John Sidney, Mina John, Karina Yusim, Tonia Woodberry, Kaori Sango, Hannah S. Hewitt, Leah Henry, Caitlyn H. Linde, John V. Chisholm, III, Tauheed M. Zaman, Eunice Pae, Simon Mallal, Bruce D Walker, Alessandro Sette, Bette T. Korber, David Heckerman, and Christian Brander. Impact of HLA-B Alleles, Epitope Binding Affinity, Functional Avidity, and Viral Coinfection on the Immunodominance of Virus-Specific CTL Responses. J. Immunol., 176(7):4094-4101, 1 Apr 2006. PubMed ID: 16547245. Show all entries for this paper.


Displaying record number 55494

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Subtype B
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords superinfection

Notes

References

Streeck2008a Hendrik Streeck, Bin Li, Art F. Y. Poon, Arne Schneidewind, Adrianne D. Gladden, Karen A. Power, Demetre Daskalakis, Suzane Bazner, Rosario Zuniga, Christian Brander, Eric S. Rosenberg, Simon D. W. Frost, Marcus Altfeld, and Todd M. Allen. Immune-Driven Recombination and Loss of Control after HIV Superinfection. J. Exp. Med., 205(8):1789-1796, 4 Aug 2008. PubMed ID: 18625749. Show all entries for this paper.


Displaying record number 55504

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Subtype B
Species (MHC/HLA) human(A1)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords characterizing CD8+ T cells

Notes

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.


Displaying record number 56463

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9(Nef)
Subtype B
Species (MHC/HLA) human(A1, A29)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords  

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 54327

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Species (MHC/HLA) human(A1, B*3701, B*5701)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay, Cytokine production, HLA binding, Other
Keywords vaccine-induced immune responses, HLA cross-presentation, HLA associated polymorphism

Notes

References

Reche2006 Pedro A. Reche, Derin B. Keskin, Rebecca E. Hussey, Petronela Ancuta, Dana Gabuzda, and Ellis L. Reinherz. Elicitation from Virus-Naive Individuals of Cytotoxic T Lymphocytes Directed against Conserved HIV-1 Epitopes. Med. Immunol., 5:1, 2006. PubMed ID: 16674822. Show all entries for this paper.


Displaying record number 1148

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128 LAI)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Subtype B
Species (MHC/HLA) human(A29, B*3501, Cw6)
Immunogen HIV-1 infection
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 55941

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9(Nef)
Subtype B
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords optimal epitope

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


Displaying record number 60465

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60469

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(B*18)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 55195

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location  
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Species (MHC/HLA) human(B37, B57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords supertype, HLA cross-presentation

Notes

References

Frahm2007b Nicole Frahm, Karina Yusim, Todd J. Suscovich, Sharon Adams, John Sidney, Peter Hraber, Hannah S. Hewitt, Caitlyn H. Linde, Daniel G. Kavanagh, Tonia Woodberry, Leah M. Henry, Kellie Faircloth, Jennifer Listgarten, Carl Kadie, Nebojsa Jojic, Kaori Sango, Nancy V. Brown, Eunice Pae, M. Tauheed Zaman, Florian Bihl, Ashok Khatri, Mina John, Simon Mallal, Francesco M. Marincola, Bruce D . Walker, Alessandro Sette, David Heckerman, Bette T. Korber, and Christian Brander. Extensive HLA Class I Allele Promiscuity among Viral CTL Epitopes. Eur. J. Immunol., 37(9):2419-2433, Sep 2007. PubMed ID: 17705138. Show all entries for this paper.


Displaying record number 1044

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128 LAI)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Subtype B
Species (MHC/HLA) human(B37, B57)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

CulmannPerCom B. Culmann. Personal communication, 1998. Show all entries for this paper.


Displaying record number 56412

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Subtype B
Species (MHC/HLA) human(B*37)
Immunogen HIV-1 infection
Country Australia, Canada, Germany, United States
Experimental methods  
Keywords HLA associated polymorphism

Notes

References

Brumme2008 Zabrina L. Brumme, Chanson J. Brumme, Jonathan Carlson, Hendrik Streeck, Mina John, Quentin Eichbaum, Brian L Block, Brett Baker, Carl Kadie, Martin Markowitz, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, John Kaldor, Yuko Yuki, Mary Carrington, Todd M. Allen, Simon Mallal, Marcus Altfeld, David Heckerman, and Bruce D. Walker. Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection. J. Virol., 82(18):9216-9227, Sep 2008. PubMed ID: 18614631. Show all entries for this paper.


Displaying record number 60470

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(B*49)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 58398

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location ( IIIB, MN)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication
Keywords rate of progression, HLA associated polymorphism, elite controllers

Notes

References

Zhang2011 YongHong Zhang, YanChun Peng, HuiPing Yan, Keyi Xu, Masumichi Saito, Hao Wu, XinYue Chen, Srinika Ranasinghe, Nozomi Kuse, Tim Powell, Yan Zhao, WeiHua Li, Xin Zhang, Xia Feng, Ning Li, Aleksandra Leligdowicz, XiaoNing Xu, Mina John, Masafumi Takiguchi, Andrew McMichael, Sarah Rowland-Jones, and Tao Dong. Multilayered Defense in HLA-B51-Associated HIV Viral Control. J. Immunol., 187(2):684-691, 15 Jul 2011. PubMed ID: 21670313. Show all entries for this paper.


Displaying record number 54875

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location  
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection, vaccine
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords vaccine-induced immune responses, characterizing CD8+ T cells

Vaccine Details

Vaccine type canarypox, canarypox prime with recombinant protein boost
Vaccine strain B clade BRU, B clade LAI, B clade MN, multiple epitope immunogen
Vaccine component Gag, gp120, gp41, Nef, Pol, Protease

Notes

References

Horton2006 Helen Horton, Ian Frank, Ruth Baydo, Emilie Jalbert, Justin Penn, Sean Wilson, John P. McNevin, Matthew D. McSweyn, Deborah Lee, Yunda Huang, Stephen C. De Rosa, and M. Juliana McElrath. Preservation of T Cell Proliferation Restricted by Protective HLA Alleles Is Critical for Immune Control of HIV-1 Infection. J. Immunol., 177(10):7406-7415, 15 Nov 2006. PubMed ID: 17082660. Show all entries for this paper.


Displaying record number 55606

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Subtype B
Species (MHC/HLA) human(B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords computational epitope prediction

Notes

References

Schellens2008 Ingrid M. M. Schellens, Can Kesmir, Frank Miedema, Debbie van Baarle, and José A. M. Borghans. An Unanticipated Lack of Consensus Cytotoxic T Lymphocyte Epitopes in HIV-1 Databases: The Contribution of Prediction Programs. AIDS, 22(1):33-37, 2 Jan 2008. PubMed ID: 18090389. Show all entries for this paper.


Displaying record number 55852

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(B*5801, B57)
Immunogen HIV-1 infection
Country Netherlands
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Navis2008a Marjon Navis, Ingrid M. M. Schellens, Peter van Swieten, José A. M. Borghans, Frank Miedema, Neeltje A. Kootstra, Debbie van Baarle, and Hanneke Schuitemaker. A Nonprogressive Clinical Course in HIV-Infected Individuals Expressing Human Leukocyte Antigen B57/5801 Is Associated with Preserved CD8+ T Lymphocyte Responsiveness to the HW9 Epitope in Nef. J. Infect. Dis., 197(6):871-879, 15 Mar 2008. PubMed ID: 18279072. Show all entries for this paper.


Displaying record number 53658

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Subtype B, C
Species (MHC/HLA) human(B57, B63)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, HLA cross-presentation, optimal epitope

Notes

References

Frahm2005a Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn H. Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco Marincola, Bruce D. Walker, Philip J. R. Goulder, and Christian Brander. HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load. J. Virol., 79(16):10218-10225, Aug 2005. PubMed ID: 16051815. Show all entries for this paper.


Displaying record number 57404

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection, in vitro stimulation or selection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords TCR usage, assay or method development

Notes

References

Balamurugan2010 Arumugam Balamurugan, Hwee L. Ng, and Otto O. Yang. Rapid T Cell Receptor Delineation Reveals Clonal Expansion Limitation of the Magnitude of the HIV-1-Specific CD8+ T Cell Response. J. Immunol., 185(10):5935-5942, 15 Nov 2010. PubMed ID: 20944001. Show all entries for this paper.


Displaying record number 54799

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CTL suppression of replication
Keywords class I down-regulation by Nef

Notes

References

Adnan2006 Sama Adnan, Arumugam Balamurugan, Alicja Trocha, Michael S. Bennett, Hwee L. Ng, Ayub Ali, Christian Brander, and Otto O. Yang. Nef Interference with HIV-1-Specific CTL Antiviral Activity Is Epitope Specific. Blood, 108(10):3414-3419, 15 Nov 2006. PubMed ID: 16882705. Show all entries for this paper.


Displaying record number 54388

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location  
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Bailey2006 Justin R. Bailey, Thomas M. Williams, Robert F. Siliciano, and Joel N. Blankson. Maintenance of Viral Suppression in HIV-1-Infected HLA-B*57+ Elite Suppressors Despite CTL Escape Mutations. J. Exp. Med., 203(5):1357-1369, 15 May 2006. PubMed ID: 16682496. Show all entries for this paper.


Displaying record number 58773

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name Nef-YT9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Australia, Canada, United States
Experimental methods Chromium-release assay
Keywords class I down-regulation by Nef

Notes

References

Chen2012 Diana Y. Chen, Arumugam Balamurugan, Hwee L. Ng, William G. Cumberland, and Otto O. Yang. Epitope Targeting and Viral Inoculum Are Determinants of Nef-Mediated Immune Evasion of HIV-1 from Cytotoxic T Lymphocytes. Blood, 120(1):100-111, 5 Jul 2012. PubMed ID: 22613796. Show all entries for this paper.


Displaying record number 61571

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name B57-YT9(nef)
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Patient MHC/HLA MS: A*02, A*31, B*51, B*57
Country Germany
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining
Keywords acute/early infection, protective allele

Notes

References

Altfeld2003a Marcus Altfeld, Marylyn M. Addo, Eric S. Rosenberg, Frederick M. Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick P. Sekaly, Jay A. Levy, Jürgen K. Rockstroh, Philip J. Goulder, and Bruce D. Walker. Influence of HLA-B57 on Clinical Presentation and Viral Control during Acute HIV-1 Infection. AIDS, 17(18):2581-2591, 5 Dec 2003. PubMed ID: 14685052. Show all entries for this paper.


Displaying record number 59307

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression

Notes

References

Streeck2014 Hendrik Streeck, Richard Lu, Noor Beckwith, Mark Milazzo, Michelle Liu, Jean-Pierre Routy, Susan Little, Heiko Jessen, Anthony D. Kelleher, Frederick Hecht, Rafick-Pierre Sekaly, Galit Alter, David Heckerman, Mary Carrington, Eric S. Rosenberg, and Marcus Altfeld. Emergence of Individual HIV-Specific CD8 T Cell Responses during Primary HIV-1 Infection Can Determine Long-Term Disease Outcome. J. Virol., 88(21):12793-12801, Nov 2014. PubMed ID: 25165102. Show all entries for this paper.


Displaying record number 2013

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name Nef-YT9
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HAART, ART

Notes

References

Sabbaj2003 Steffanie Sabbaj, Anju Bansal, G. Douglas Ritter, Christopher Perkins, Bradley H. Edwards, Ethan Gough, Jianming Tang, James J. Szinger, Bette Korber, Craig M. Wilson, Richard A. Kaslow, Mark J. Mulligan, and Paul A. Goepfert. Cross-Reactive CD8+ T Cell Epitopes Identified in US Adolescent Minorities. J. Acquir. Immune Defic. Syndr., 33(4):426-438, 1 Aug 2003. PubMed ID: 12869831. Show all entries for this paper.


Displaying record number 54823

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name nefYT9
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Kenya, United Kingdom
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords TCR usage, structure, characterizing CD8+ T cells

Notes

References

Gillespie2006 Geraldine M. A. Gillespie, Guillaume Stewart-Jones, Jaya Rengasamy, Tara Beattie, Job J. Bwayo, Francis A. Plummer, Rupert Kaul, Andrew J. McMichael, Philippa Easterbrook, Tao Dong, E. Yvonne Jones, and Sarah L. Rowland-Jones. Strong TCR Conservation and Altered T Cell Cross-Reactivity Characterize a B*57-Restricted Immune Response in HIV-1 Infection. J. Immunol., 177(6):3893-3902, 15 Sep 2006. PubMed ID: 16951352. Show all entries for this paper.


Displaying record number 59213

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Show epitope variants
Epitope Name YT9
Subtype B
Species (MHC/HLA) human(B*5701)
Immunogen HIV-1 infection
Patient MHC/HLA P1: B*5701; P2: B*5701; P4: B*5701
Country United States
Experimental methods Other
Keywords elite controllers

Notes

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 57039

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Subtype A1
Species (MHC/HLA) human(B58)
Immunogen HIV-1 infection
Country Sweden
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords subtype comparisons, computational epitope prediction, vaccine antigen design

Notes

References

Perez2008 Carina L. Pérez, Mette V. Larsen, Rasmus Gustafsson, Melissa M. Norström, Ann Atlas, Douglas F. Nixon, Morten Nielsen, Ole Lund, and Annika C. Karlsson. Broadly Immunogenic HLA Class I Supertype-Restricted Elite CTL Epitopes Recognized in a Diverse Population Infected with Different HIV-1 Subtypes. J. Immunol., 180(7):5092-5100, 1 Apr 2008. PubMed ID: 18354235. Show all entries for this paper.


Displaying record number 60468

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(C*01)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60467

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(C*06)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 60466

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Species (MHC/HLA) human(C*14)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords rate of progression, optimal epitope

Notes

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.


Displaying record number 54141

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location  
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Species (MHC/HLA) human(Cw*06)
Immunogen  
Experimental methods  
Keywords optimal epitope

Notes

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.


Displaying record number 61662

HXB2 Location Nef(120-128)
DNA(9145..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Epitope Name YT9
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA AC1: A*0201, A*3001, B*3701, B*3801, Cw*0602, Cw*1203; VP1: A*0201, A*0301, B*4101, B*5201, Cw*0303, Cw*1701; AP4: A*03, A*23, B*07, B*45; ES3: A*25, A*68, B*51, B*57; ES4: A*02, A*30, B*08, B*44; ES5: A*23, A*68, B*57, B*58; ES9: A*02, A*30, B*27, B*57; ES22: A*30, A*31, B*15, B*57; ES24: A*30, A*31, B*15, B*57; ES31: A*03, B*27, B*58; ES46: A*03, B*57, B*65; ES47: A*02, A*33, B*44, B*63; VC1: A*23, A*29, B*07, B*39; VC18: A*03, A*23, B*44, B*51
Country United States
Experimental methods Other, Relative replication capacity assay
Keywords NK cells, transmission pair

Notes

References

Walker-Sperling2017 Victoria E. Walker-Sperling, Christopher W. Pohlmeyer, Rebecca T. Veenhuis, Megan May, Krystle A. Luna, Allison R. Kirkpatrick, Oliver Laeyendecker, Andrea L. Cox, Mary Carrington, Justin R. Bailey, Roberto C. Arduino, and Joel N. Blankson. Factors Associated with the Control of Viral Replication and Virologic Breakthrough in a Recently Infected HIV-1 Controller. EBioMedicine, 16:141-149, Feb 2017. PubMed ID: 28159573. Show all entries for this paper.


Displaying record number 1043

HXB2 Location Nef(120-128)
DNA(9154..9180)
Nef Epitope Map
Author Location Nef(120-128)
Epitope YFPDWQNYT Epitope Alignment
YFPDWQNYT epitope logo
Species (MHC/HLA) human
Immunogen HIV-1 infection
Experimental methods  
Keywords immunodominance

Notes

References

Betts2000 M. R. Betts, J. P. Casazza, B. A. Patterson, S. Waldrop, W. Trigona, T.-M Fu, F. Kern, L. J. Picker, and R. A. Koup. Putative Immunodominant Human Imunodeficiency Virus-Specific CD8+ T Cell Responses Cannot Be Predicted by Major Histocompatibility Complex Class I Haplotype. J. Virol., 74:9144-9151, 2000. PubMed ID: 10982361. Show all entries for this paper.


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