HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 8 matching records:

Displaying record number 54077

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HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location ( C consensus)
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Subtype C
Species (MHC/HLA) human(A*29)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, optimal epitope

Notes

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.


Displaying record number 53327

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HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location ( C consensus)
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Subtype C
Species (MHC/HLA) human(A*29, A*30:02)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords HLA cross-presentation, characterizing CD8+ T cells

Notes

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.


Displaying record number 56232

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HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location  
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Subtype C
Species (MHC/HLA) human(A29, B*58:01, B57)
Immunogen HIV-1 infection
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords rate of progression

Notes

References

Gray2009 Clive M. Gray, Mandla Mlotshwa, Catherine Riou, Tiyani Mathebula, Debra de Assis Rosa, Tumelo Mashishi, Cathal Seoighe, Nobubelo Ngandu, Francois van Loggerenberg, Lynn Morris, Koleka Mlisana, Carolyn Williamson, Salim Abdool Karim, and CAPRISA 002 Acute Infection Study Team. Human Immunodeficiency Virus-Specific gamma Interferon Enzyme-Linked Immunospot Assay Responses Targeting Specific Regions of the Proteome during Primary Subtype C Infection Are Poor Predictors of the Course of Viremia and Set Point. J. Virol., 83(1):470-478, Jan 2009. PubMed ID: 18945774. Show all entries for this paper.


Displaying record number 57765

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HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Subtype C
Species (MHC/HLA) human(A*29:02, A*30:02)
Immunogen HIV-1 infection
Patient MHC/HLA A*29:02, A*66:01, B*45:01, B*58:02, C*06:02, C*06:02; A*30:02, A*30:02, B*08:01, B*45:01, C*07:01, C*16:01
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords rate of progression, acute/early infection

Notes

References

Mlotshwa2010 Mandla Mlotshwa, Catherine Riou, Denis Chopera, Debra de Assis Rosa, Roman Ntale, Florette Treunicht, Zenda Woodman, Lise Werner, Francois van Loggerenberg, Koleka Mlisana, Salim Abdool Karim, Carolyn Williamson, Clive M Gray, and CAPRISA 002 Study Team. Fluidity of HIV-1-Specific T-Cell Responses during Acute and Early Subtype C HIV-1 Infection and Associations with Early Disease Progression. J. Virol., 84(22):12018-12029, Nov 2010. PubMed ID: 20826686. Show all entries for this paper.


Displaying record number 57276

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HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location Nef
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Epitope Name YY8
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country Barbados, Haiti, Jamaica
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords mother-to-infant transmission, elite controllers

Notes

References

Schneidewind2009 Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noel, Todd M. Allen, Celia D. Christie, and Margaret E. Feeney. Maternal Transmission of Human Immunodeficiency Virus Escape Mutations Subverts HLA-B57 Immunodominance but Facilitates Viral Control in the Haploidentical Infant. J. Virol., 83(17):8616-8627, Sep 2009. PubMed ID: 19515764. Show all entries for this paper.


Displaying record number 57420

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HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location  
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Show epitope variants
Epitope Name YY8
Subtype B
Species (MHC/HLA) human(B*57)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords elite controllers

Notes

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


Displaying record number 53644

Download this epitope record as JSON.

HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location  
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Species (MHC/HLA) human(B*58:01, B57)
Immunogen HIV-1 infection
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords responses in children, mother-to-infant transmission, escape

Notes

References

Feeney2005a Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen A. Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori Verrill, Todd Allen, Corey Moore, Simon Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, and Philip J. R. Goulder. HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response. J. Immunol., 174(12):7524-7530, 15 Jun 2005. PubMed ID: 15944251. Show all entries for this paper.


Displaying record number 58954

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HXB2 Location Nef(120-127)
DNA(9154..9177)
Nef Epitope Map
Author Location Nef(120-127)
Epitope YFPDWQNY Epitope Alignment
YFPDWQNY epitope logo
Subtype C
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA CAP085: A*30:02, B*08:01, B*45:01, C*07:01, C*16:01
Country South Africa
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords escape, acute/early infection

Notes

References

Abrahams2013 Melissa-Rose Abrahams, Florette K. Treurnicht, Nobubelo K. Ngandu, Sarah A. Goodier, Jinny C. Marais, Helba Bredell, Ruwayhida Thebus, Debra de Assis Rosa, Koleka Mlisana, Cathal Seoighe, Salim Abdool Karim, Clive M. Gray, and Carolyn Williamson. Rapid, Complex Adaptation of Transmitted HIV-1 Full-Length Genomes in Subtype C-Infected Individuals with Differing Disease Progression. AIDS, 27(4):507-518, 20 Feb 2013. PubMed ID: 23370465. Show all entries for this paper.


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