HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 7 matching records:

Displaying record number 62214

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HXB2 Location gp160(435-443)
gp120(435-443)
DNA(7527..7553)
gp160 Epitope Map
Author Location gp120(435-443)
Epitope YAPPISGQI Epitope Alignment
YAPPISGQI epitope logo
Subtype B
Species (MHC/HLA) human(B*51)
Immunogen HIV-1 infection, vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine-induced immune responses, therapeutic vaccine

Vaccine Details

Vaccine type DNA prime with Ad5 boost
Vaccine strain A clade, B clade, C clade
Vaccine component Env, Gag, Nef, Pol

Notes

References

Casazza2013 Joseph P. Casazza, Kathryn A. Bowman, Selorm Adzaku, Emily C. Smith, Mary E. Enama, Robert T. Bailer, David A. Price, Emma Gostick, Ingelise J. Gordon, David R. Ambrozak, Martha C. Nason, Mario Roederer, Charla A. Andrews, Frank M. Maldarelli, Ann Wiegand, Mary F. Kearney, Deborah Persaud, Carrie Ziemniak, Raphael Gottardo, Julie E. Ledgerwood, Barney S. Graham, Richard A. Koup, and VRC 101 Study Team. Therapeutic Vaccination Expands and Improves the Function of the HIV-Specific Memory T-Cell Repertoire. J. Infect. Dis., 207(12):1829-1840, 15 Jun 2013. PubMed ID: 23482645. Show all entries for this paper.


Displaying record number 57921

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HXB2 Location gp160(435-443)
gp120(435-443)
DNA(7527..7553)
gp160 Epitope Map
Author Location Env( 89.6P)
Epitope YAPPISGQI Epitope Alignment
YAPPISGQI epitope logo
Show epitope variants
Epitope Name p41A
Subtype B
Species (MHC/HLA) macaque(Mamu-A*01)
Immunogen SHIV infection, vaccine
Experimental methods Flow cytometric T-cell cytokine assay, Intracellular cytokine staining, Tetramer binding
Keywords vaccine-induced immune responses, variant cross-reactivity

Vaccine Details

Vaccine type adenovirus type 5 (Ad5)
Vaccine strain B clade 89.6P
Vaccine component Env

Notes

References

Hulot2011 Sandrine L. Hulot, Evan M. Cale, Bette T. Korber, and Norman L. Letvin. Vaccine-Induced CD8+ T Lymphocytes of Rhesus Monkeys Recognize Variant Forms of an HIV Epitope but Do Not Mediate Optimal Functional Activity. J. Immunol., 186(10):5663-5674, 15 May 2011. PubMed ID: 21490161. Show all entries for this paper.


Displaying record number 1250

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HXB2 Location gp160(435-443)
gp120(435-443)
DNA(7527..7553)
gp160 Epitope Map
Author Location gp41( 89.6)
Epitope YAPPISGQI Epitope Alignment
YAPPISGQI epitope logo
Epitope Name p41A
Species (MHC/HLA) macaque(Mamu-A*01)
Immunogen SHIV infection, vaccine
Experimental methods  
Keywords immunodominance

Vaccine Details

Vaccine type DNA, modified vaccinia Ankara (MVA)
Vaccine strain B clade 89.6, B clade HXBc2
Vaccine component Env, Gag
Adjuvant IL-2/Ig

Notes

References

Barouch2001 D. H. Barouch, A. Craiu, S. Santra, M. A. Egan, J. E. Schmitz, M. J. Kuroda, T. M. Fu, J. H. Nam, L. S. Wyatt, M. A. Lifton, G. R. Krivulka, C. E. Nickerson, C. I. Lord, B. Moss, M. G. Lewis, V. M. Hirsch, J. W. Shiver, and N. L. Letvin. Elicitation of high-frequency cytotoxic T-lymphocyte responses against both dominant and subdominant simian-human immunodeficiency virus epitopes by DNA vaccination of rhesus monkeys. J. Virol., 75(5):2462-7, Mar 2001. URL: http://jvi.asm.org/cgi/content/full/75/5/2462. PubMed ID: 11160750. Show all entries for this paper.


Displaying record number 801

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HXB2 Location gp160(435-443)
gp120(435-443)
DNA(7527..7553)
gp160 Epitope Map
Author Location  
Epitope YAPPISGQI Epitope Alignment
YAPPISGQI epitope logo
Species (MHC/HLA) macaque(Mamu-A*01)
Immunogen SHIV infection
Experimental methods  
Keywords  

Notes

References

Egan1999 M. A. Egan, M. J. Kuroda, G. Voss, J. E. Schmitz, W. A. Charini, C. I. Lord, M. A. Forman, and N. L. Letvin. Use of Major Histocompatibility Complex Class I/peptide/beta2M Tetramers to Quantitate CD8+ Cytotoxic T Lymphocytes Specific for Dominant and Nondominant Viral Epitopes in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys. J. Virol., 73:5466-5472, 1999. PubMed ID: 10364294. Show all entries for this paper.


Displaying record number 53189

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HXB2 Location gp160(435-443)
gp120(435-443)
DNA(7527..7553)
gp160 Epitope Map
Author Location Env
Epitope YAPPISGQI Epitope Alignment
YAPPISGQI epitope logo
Species (MHC/HLA) macaque(Mamu-A*01)
Immunogen vaccine
Experimental methods Flow cytometric T-cell cytokine assay
Keywords rate of progression, vaccine-induced immune responses, kinetics, memory cells, characterizing CD8+ T cells

Vaccine Details

Vaccine type DNA
Vaccine strain B clade 89.6P, SIV
Vaccine component Env, Gag

Notes

References

Davenport2004 Miles P. Davenport, Ruy M. Ribeiro, and Alan S. Perelson. Kinetics of Virus-Specific CD8+ T Cells and the Control of Human Immunodeficiency Virus Infection. J. Virol., 78(18):10096-10103, Sep 2004. PubMed ID: 15331742. Show all entries for this paper.


Displaying record number 1635

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HXB2 Location gp160(435-443)
gp120(435-443)
DNA(7527..7553)
gp160 Epitope Map
Author Location Env( 89.6)
Epitope YAPPISGQI Epitope Alignment
YAPPISGQI epitope logo
Epitope Name p41A
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods  
Keywords immunodominance

Vaccine Details

Vaccine type vaccinia
Vaccine strain B clade 89.6, SIV
Vaccine component Env, Gag-Pol
Adjuvant IL-2/Ig

Notes

References

Barouch2001b D. H. Barouch, S. Santra, M. J. Kuroda, J. E. Schmitz, R. Plishka, A. Buckler-White, A. E. Gaitan, R. Zin, J. H. Nam, L. S. Wyatt, M. A. Lifton, C. E. Nickerson, B. Moss, D. C. Montefiori, V. M. Hirsch, and N. L. Letvin. Reduction of simian-human immunodeficiency virus 89.6P viremia in rhesus monkeys by recombinant modified vaccinia virus Ankara vaccination. J. Virol., 75(11):5151-8, Jun 2001. URL: http://jvi.asm.org/cgi/content/full/75/11/5151. PubMed ID: 11333896. Show all entries for this paper.


Displaying record number 1251

Download this epitope record as JSON.

HXB2 Location gp160(435-443)
gp120(435-443)
DNA(7527..7553)
gp160 Epitope Map
Author Location Env( 89.6)
Epitope YAPPISGQI Epitope Alignment
YAPPISGQI epitope logo
Epitope Name p41A
Species (MHC/HLA) macaque
Immunogen vaccine
Experimental methods  
Keywords  

Vaccine Details

Vaccine type DNA
Vaccine strain B clade 89.6, SIV
Vaccine component Env, Gag
Adjuvant IL-2/Ig

Notes

References

Barouch2000 D. H. Barouch, S. Santra, J. E. Schmitz, M. J. Kuroda, T. M. Fu, W. Wagner, M. Bilska, A. Craiu, X. X. Zheng, G. R. Krivulka, K. Beaudry, M. A. Lifton, C. E. Nickerson, W. L. Trigona, K. Punt, D. C. Freed, L. Guan, S. Dubey, D. Casimiro, A. Simon, M. E. Davies, M. Chastain, T. B. Strom, R. S. Gelman, D. C. Montefiori, M. G. Lewis, E. A. Emini, J. W. Shiver, and N. L. Letvin. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science, 290(5491):486-92, 20 Oct 2000. PubMed ID: 11039923. Show all entries for this paper.

Shen2000 X. Shen and R. F. Siliciano. Preventing AIDS but not HIV-1 infection with a DNA vaccine. Science, 290(5491):463-5, 20 Oct 2000. PubMed ID: 11183769. Show all entries for this paper.


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