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Displaying record number 55563

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HXB2 Location	Nef(13-20) DNA(8833..8856)	Nef Epitope Map
Author Location	Nef(13-20)
Epitope	`WSMVRERM`	Epitope Alignment
Epitope Name	WM8
Subtype	B
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A68:01, B51, B8, C15, Cw7, DQ2, DQ3, DR3, DR4
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Other
Keywords	rate of progression, escape, mutation acquisition

Notes

An LTNP was followed longitudinally over 6 years and 3 sampling time points, until transition to disease. His HLA were heterozygous and not associated with nonprogressive infection, but 3 alleles were associated with poor clinical prognosis. No attenuating mutations in initial samplings, but an insertion in the V2 loop and continuing CCR5 coreceptor use were found.
A decrease in IFN-gamma response was seen over time, suggesting CTL dysfunction. An increase in T-cell epitopes targeted (e.g. emergence of YL8, YLKDQQLL and WY20, WKFDSRLAFHHMARELHPEY variants and gain of response to EL9, EIKDTKEAL, NL10, NSNPDCKTIL, AK9, AIFQSSMTK, WM8, WSMVRERM, VT15, WVHHTQGYFPDWQNYT) was seen concomitant with disease progression, reflecting viral replication and/or variants.
HLA-B8-restricted epitope WSMVRERM was able to elicit CTL response only by the last time point. HLA restriction was predicted in this study based on the patient's HLA alleles and previous publication.

References

Kemal2008 Kimdar Sherefa Kemal, Tara Beattie, Tao Dong, Barbara Weiser, Rupert Kaul, Carla Kuiken, Julian Sutton, Dorothy Lang, Hongbing Yang, Yan Chun Peng, Ronald Collman, Sean Philpott, Sarah Rowland-Jones, and Harold Burger. Transition from Long-Term Nonprogression to HIV-1 Disease Associated with Escape from Cellular Immune Control. J. Acquir. Immune Defic. Syndr., 48(2):119-126, 1 Jun 2008. PubMed ID: 18520675. Show all entries for this paper.