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Displaying record number 55509

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HXB2 Location	Nef(183-193) DNA(9343..9375)	Nef Epitope Map
Author Location	Nef
Epitope	WRFDSRLAHH	Epitope Alignment
Epitope Name	WH10
Subtype	B
Species (MHC/HLA)	human(A1)
Immunogen	HIV-1 infection
Country	United States
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay, Tetramer binding
Keywords	dynamics, characterizing CD8+ T cells, chronic infection

Notes

• T-cells were studied for exhaustion and dysfunction in chronic HIV infection. Polyfunctionality of CTL immune response to HIV-1 decreased with persistence of antigen presence over time in chronic infection. CTL exhaustion can thus be halted by reduction in viral antigen load - either by ART or through escape mutations.
• PD-1, marker for activation and apoptosis increases over time, but it decreases when epitope mutations develop. CD127 however, is not impacted by viral escape.
• 215 days after first testing, epitope WRFDSRLAHH varied to WkFDSlLAHH in an untreated patient, Ac-183. Previously published HLA-restriction for WH10 is HLA-A1.

References

Streeck2008 Hendrik Streeck, Zabrina L. Brumme, Michael Anastario, Kristin W. Cohen, Jonathan S. Jolin, Angela Meier, Chanson J. Brumme, Eric S. Rosenberg, Galit Alter, Todd M. Allen, Bruce D. Walker, and Marcus Altfeld. Antigen Load and Viral Sequence Diversification Determine the Functional Profile of HIV-1-Specific CD8+ T Cells. PLoS Med, 5(5):e100, 6 May 2008. PubMed ID: 18462013. Show all entries for this paper.