Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 55858

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HXB2 Location	Nef(13-20) DNA(8833..8856)	Nef Epitope Map
Author Location	Nef(260-267)
Epitope	WPAIRERM	Epitope Alignment
		Show epitope variants
Epitope Name	WM8
Subtype	B
Species (MHC/HLA)	human(B*08)
Immunogen	HIV-1 infection
Patient MHC/HLA	A1, A2, B49, B8, Cw7
Country	Germany
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	escape, mutation acquisition

Notes

• The Nef HLA-B8-restricted dominant epitope FL8, FLKEKGGL, was studied both longitudinally over time as well as horizontally in a 56 subject cohort of HIV-1 infected patients to chart FL8 variants. FL8 mutants were associated with higher pVL and lower CD4 cell counts.
• Patient 01 who was studied over time accumulated a mutation in WPAIRERM to WPAIRaRM concomitant with a strong viremic increase. Original autologous and viral variant sequences were both tested for response: the original epitope elicited a CTL response but a strong decrease in recognition was seen with the variant, suggesting an escape.
• HLA restrictions in this study are previously published and correlate with the subject's HLA.

References

Maurer2008 Katja Maurer, Ellen G. Harrer, Andreas Goldwich, Kathrin Eismann, Silke Bergmann, Matthias Schmitt-Haendle, Bernd Spriewald, Sandra M. Mueller, Thomas Harrer, and German Competence Network for HIV/AIDS. Role of Cytotoxic T-Lymphocyte-Mediated Immune Selection in a Dominant Human Leukocyte Antigen-B8-Restricted Cytotoxic T-Lymphocyte Epitope in Nef. J. Acquir. Immune Defic. Syndr., 48(2):133-141, 1 Jun 2008. PubMed ID: 18391752. Show all entries for this paper.

Displaying record number 53286

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HXB2 Location	Nef(13-20) DNA(8833..8856)	Nef Epitope Map
Author Location	( C consensus)
Epitope	WPAIRERM	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(B*08:01)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	characterizing CD8+ T cells

Notes

• HLA class I restricted CD8+ T-cell responses against HIV-1 were analyzed in African patients. Significantly more responses were shown to be HLA-B restricted. Viral load, CD4 count, and thus rate of disease progression were also associated with HLA-B alleles. In addition, the selection pressure imposed on HIV-1 by HLA-B alleles was shown to be substantially greater than by other alleles.
• This epitope was suggested to be the epitope within a longer reactive peptide based on correspondence with a known epitope in the HIV database. Also, a significantly higher frequency of people in the Durban cohort who reacted with the peptide had this HLA type.

References

Kiepiela2004 Photini Kiepiela, Alasdair J. Leslie, Isobella Honeyborne, Danni Ramduth, Christina Thobakgale, Senica Chetty, Prinisha Rathnavalu, Corey Moore, Katja J. Pfafferott, Louise Hilton, Peter Zimbwa, Sarah Moore, Todd Allen, Christian Brander, Marylyn M. Addo, Marcus Altfeld, Ian James, Simon Mallal, Michael Bunce, Linda D. Barber, James Szinger, Cheryl Day, Paul Klenerman, James Mullins, Bette Korber, Hoosen M. Coovadia, Bruce D. Walker, and Philip J. R. Goulder. Dominant Influence of HLA-B in Mediating the Potential Co-Evolution of HIV and HLA. Nature, 432(7018):769-775, 9 Dec 2004. LA-UR 04-5920. PubMed ID: 15592417. Show all entries for this paper.

Displaying record number 54071

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HXB2 Location	Nef(13-20) DNA(8833..8856)	Nef Epitope Map
Author Location	( C consensus)
Epitope	WPAIRERM	Epitope Alignment
Subtype	C
Species (MHC/HLA)	human(B*08:01)
Immunogen	HIV-1 infection
Country	South Africa
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression, optimal epitope

Notes

• A comprehensive analysis of 160 class I T cell responses in 578 individuals from KwaZulu-Natal, South Africa was performed. Gag-specific responses were associated with lowering viremia, while Env, accessory and regulatory protein-specific responses were associated with higher viremia.
• WPAIRERM is an optimal epitope.

References

Kiepiela2007 Photini Kiepiela, Kholiswa Ngumbela, Christina Thobakgale, Dhanwanthie Ramduth, Isobella Honeyborne, Eshia Moodley, Shabashini Reddy, Chantal de Pierres, Zenele Mncube, Nompumelelo Mkhwanazi, Karen Bishop, Mary van der Stok, Kriebashnie Nair, Nasreen Khan, Hayley Crawford, Rebecca Payne, Alasdair Leslie, Julia Prado, Andrew Prendergast, John Frater, Noel McCarthy, Christian Brander, Gerald H. Learn, David Nickle, Christine Rousseau, Hoosen Coovadia, James I. Mullins, David Heckerman, Bruce D. Walker, and Philip Goulder. CD8+ T-Cell Responses to Different HIV Proteins Have Discordant Associations with Viral Load. Nat. Med., 13(1):46-53, Jan 2007. PubMed ID: 17173051. Show all entries for this paper.