Search CTL/CD8+ T-Cell Epitope Database

Found 13 matching records:

Displaying record number 60451

HXB2 Location	Vif(79-87) DNA(5275..5301)	Vif Epitope Map
Author Location	Vif(79-87)
Epitope	`WHLGQGVSI`	Epitope Alignment
Epitope Name	WI9
Species (MHC/HLA)	human(A*32)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
WHLGQGVSI had a significantly positive association with HLA A*32; it was recognized by 2/16 A*32-positive subjects and 1/118 A*32-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60449

HXB2 Location	Vif(79-87) DNA(5275..5301)	Vif Epitope Map
Author Location	Vif(79-87)
Epitope	`WHLGQGVSI`	Epitope Alignment
Epitope Name	WI9
Species (MHC/HLA)	human(B*1510)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
WHLGQGVSI had a significantly positive association with HLA B*1510; it was recognized by 2/3 B*1510-positive subjects and 13/221 B*1510-negative subjects.

References

Displaying record number 61691

HXB2 Location	Vif(79-87) DNA(5275..5301)	Vif Epitope Map
Author Location	Vif(79-87)
Epitope	`WHLGQGVSI`	Epitope Alignment
Epitope Name	WI9
Species (MHC/HLA)	human(B*1510)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	review

Notes

This review makes the argument that T-cell subsets recognizing the HIV/SIV viral infectivity factor Vif, may be essential for control of HIV replication as vif,/i>-deficient strains can only complete one round of replication and Vif targets the cellular viral-restriction-factor, APOBEC3G (A3G) with the help of Elongin B/C and Cullin-5 to proteasomal degradation.

HIV-1 HLA-B*1510 restricted epitope WI9, WHLGQGVSI (Vif 79-87) overlaps the Vif A3F binding domain, TGERDW.

References

Silver2017 Zachary A. Silver and David I. Watkins. The Role of MHC Class I Gene Products in SIV Infection of Macaques. Immunogenetics, 69(8-9):511-519, Aug 2017. PubMed ID: 28695289. Show all entries for this paper.

Displaying record number 60447

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Epitope Name WI9

Species (MHC/HLA) human(B*3502, B*3503, B*5301)

Immunogen HIV-1 infection

Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay

Keywords rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.

WHLGQGVSI had a significantly positive association with HLA B*3502,B*3503,B*5301; it was recognized by 8/31 B*3502,B*3503,B*5301-positive subjects and 15/224 B*3502,B*3503,B*5301-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 56023

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif

Epitope WHLGQGVSI Epitope Alignment

Epitope Name WI9(Vif)

Subtype B

Species (MHC/HLA) human(B*38)

Immunogen HIV-1 infection

Country China

Experimental methods CD8 T-cell Elispot - IFNγ

Keywords

Notes

49 ART-naive chronically HIV-1 infected Chinese subjects' CTLs were tested with 413 OLPs in IFN-gamma assays, determining optimal epitopes specific for Chinese Clade B HIV-1 sequences.

An inverse correlation was found between CTL response and viral load.

Targeted peptides have lower entropy than peptides that are not CTL targeted. This correlation is independent of HLA-restriction.

Previously described HLA-B38-restricted epitope WHLGQGVSI elicited an immune response in Chinese HIV-1 positive subjects as part of peptide LHTGERDWHLGQGVSIEW.

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.

Displaying record number 61604

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif

Epitope WHLGQGVSI Epitope Alignment

Show epitope variants

Epitope Name B38-WI9 Vif

Species (MHC/HLA) human(B*38)

Immunogen HIV-1 infection

Experimental methods Other

Keywords escape

Notes

Proof of principle is given to show that HIV-1 genome sequence from short reads can be used to reconstruct actual whole genome haplotypes including immune escape mutations. 30 whole genome haplotypes from subject 9213 were reconstructed longitudinally and published. Mutations are found to change depending on linkage and resulting clonal interference shows that selection coefficients to study HIV evolution must be estimated for complete haplotypes and not individual escapes.

Dominant Vif epitope, WI9, WHLGQGVSI was present as WT in haplotypes studied, at days 0-59, but by day 59 had begun escape for Patient 9213. Mutations seen were WHLGQGVaI (S8A), WHLGQGaSI (V7A) and anchor residue change, WHLGQGVSv (I9V).

References

Pandit2014 Aridaman Pandit and Rob J. de Boer. Reliable Reconstruction of HIV-1 Whole Genome Haplotypes Reveals Clonal Interference and Genetic Hitchhiking among Immune Escape Variants. Retrovirology, 11:56, 4 Jul 2014. PubMed ID: 24996694. Show all entries for this paper.

Displaying record number 52563

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Species (MHC/HLA) human(B*3801)

Immunogen HIV-1 infection

Experimental methods

Keywords optimal epitope

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 61022

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Subtype B

Species (MHC/HLA) human(B*3801)

Immunogen HIV-1 infection

Patient MHC/HLA 25327: A*2301, A*2601, B*3801, B*3801, Cw*0401, Cw*1203

Country United States

Experimental methods CD8 T-cell Elispot - IFNγ

Keywords acute/early infection

Notes

The extent to which set-point viremia is affected by early HIV-infection T cell responses to either conserved or variable epitopes was studied. 23 ART-naive subjects were characterized for CTL responses for 6 months, postinfection. While most CTL responses (73/123) were targeted against variable HIV-1 epitopes, recognition of conserved epitopes (16/123) was associated with lower set point viremia. This was independent of HLA type and also functional avidity of the CTL response. Most of the conserved responses were targeted to Gag and Pol epitopes.

WHLGQGVSI , restricted by B*3801, was recognized by 1 patient with the restricting allele.

References

Kunwar2013 Pratima Kunwar, Natalie Hawkins, Warren L. Dinges, Yi Liu, Erin E. Gabriel, David A. Swan, Claire E. Stevens, Janine Maenza, Ann C. Collier, James I. Mullins, Tomer Hertz, Xuesong Yu, and Helen Horton. Superior Control of HIV-1 Replication by CD8+ T Cells Targeting Conserved Epitopes: Implications for HIV Vaccine Design. PLoS One, 8(5):e64405, 2013. PubMed ID: 23741326. Show all entries for this paper.

Displaying record number 60444

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Epitope Name WI9

Species (MHC/HLA) human(B*40)

Immunogen HIV-1 infection

Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay

Keywords rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.

WHLGQGVSI had a significantly positive association with HLA B*40; it was recognized by 10/26 B*40-positive subjects and 23/255 B*40-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60450

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Epitope Name WI9

Species (MHC/HLA) human(B*52)

Immunogen HIV-1 infection

Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay

Keywords rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.

WHLGQGVSI had a significantly positive association with HLA B*52; it was recognized by 1/4 B*52-positive subjects and 0/114 B*52-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60445

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Epitope Name WI9

Species (MHC/HLA) human(B*81)

Immunogen HIV-1 infection

Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay

Keywords rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.

WHLGQGVSI had a significantly positive association with HLA B*81; it was recognized by 7/10 B*81-positive subjects and 50/331 B*81-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60448

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Epitope Name WI9

Species (MHC/HLA) human(C*07)

Immunogen HIV-1 infection

Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay

Keywords rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.

WHLGQGVSI had a significantly positive association with HLA C*07; it was recognized by 10/87 C*07-positive subjects and 3/134 C*07-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60446

HXB2 Location Vif(79-87)
DNA(5275..5301) Vif Epitope Map

Author Location Vif(79-87)

Epitope WHLGQGVSI Epitope Alignment

Epitope Name WI9

Species (MHC/HLA) human(C*12)

Immunogen HIV-1 infection

Experimental methods CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay

Keywords rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.

WHLGQGVSI had a significantly positive association with HLA C*12; it was recognized by 17/50 C*12-positive subjects and 33/281 C*12-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.