Search CTL/CD8+ T-Cell Epitope Database

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Displaying record number 58270

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HXB2 Location	gp160(44-53) gp120(44-53) DNA(6354..6383)	gp160 Epitope Map
Author Location	Env
Epitope	VWKDAKTTLF	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

• To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
• Env epitope VWKDAKTTLF stimulated peak EliSpot response in no subjects, but stimulated peak proliferation response in 2 subjects none of whom had reached disease end point.

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.

Displaying record number 58271

Download this epitope record as JSON.

HXB2 Location	gp160(44-53) gp120(44-53) DNA(6354..6383)	gp160 Epitope Map
Author Location	Env
Epitope	VWKDAKTTLF	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Kenya
Experimental methods	CD8 T-cell Elispot - IFNγ
Keywords	rate of progression

Notes

• To test whether CTL proliferation is a cause or result of immune protection, 31 ART-naive subjects in the chronic phase of HIV-1 infection were followed longitudinally for 121 person-years for Env-specific responses. Delayed disease progression was strongly correlated with CTL proliferation. Age, baseline viral load (VL), IFN-gamma EliSpot responses were not predictors of disease progression.
• Env epitope VWKDAKTTLF stimulated peak EliSpot response in no subjects, but stimulated peak proliferation response in 2 subjects none of whom had reached disease end point.

References

McKinnon2012 Lyle R. McKinnon, Rupert Kaul, Joshua Kimani, Nico J. Nagelkerke, Charles Wachihi, Keith R. Fowke, Terry Blake Ball, and Francis A. Plummer. HIV-Specific CD8+ T-Cell Proliferation Is Prospectively Associated with Delayed Disease Progression. Immunol. Cell Biol., 90(3):346-351, Mar 2012. PubMed ID: 21606945. Show all entries for this paper.