HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 4 matching records:

Displaying record number 56194

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HXB2 Location Pol(67-76)
Protease(11-20)
DNA(2283..2312)
Pol Epitope Map
Author Location Pol(98-)
Epitope VTIKIGGQLK Epitope Alignment
VTIKIGGQLK epitope logo
Species (MHC/HLA) human(A*03:01)
Immunogen vaccine
Country Botswana, United States
Experimental methods CD8 T-cell Elispot - IFNγ, Chromium-release assay
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine strain multiple epitope immunogen

Notes

References

Gorse2008a Geoffrey J. Gorse, Lindsey R. Baden, Margaret Wecker, Mark J. Newman, Guido Ferrari, Kent J. Weinhold, Brian D. Livingston, Tonya L. Villafana, Hongli Li, Elizabeth Noonan, Nina D. Russell, and HIV Vaccine Trials Network. Safety and Immunogenicity of Cytotoxic T-Lymphocyte Poly-Epitope, DNA Plasmid (EP HIV-1090) Vaccine in Healthy, Human Immunodeficiency Virus Type 1 (HIV-1)-Uninfected Adults. Vaccine, 26(2):215-223, 10 Jan 2008. PubMed ID: 18055072. Show all entries for this paper.


Displaying record number 53068

Download this epitope record as JSON.

HXB2 Location Pol(67-76)
Protease(11-20)
DNA(2283..2312)
Pol Epitope Map
Author Location Pol
Epitope VTIKIGGQLK Epitope Alignment
VTIKIGGQLK epitope logo
Show epitope variants
Epitope Name Pol 98
Subtype M group
Species (MHC/HLA) human, humanized mouse, mouse(A*11:01)
Immunogen in vitro stimulation or selection, vaccine
Experimental methods Cytokine production, T-cell Elispot
Keywords subtype comparisons, computational epitope prediction, escape, TCR usage, variant cross-reactivity

Vaccine Details

Vaccine type DNA, peptide
Adjuvant Incomplete Freund's Adjuvant (IFA)

Notes

References

McKinney2004 Denise M. McKinney, Rhonda Skvoretz, Brian D. Livingston, Cara C. Wilson, Michelle Anders, Robert W. Chesnut, Alessandro Sette, Max Essex, Vladimir Novitsky, and Mark J. Newman. Recognition of Variant HIV-1 Epitopes from Diverse Viral Subtypes by Vaccine-Induced CTL. J. Immunol., 173(3):1941-1950, 1 Aug 2004. PubMed ID: 15265928. Show all entries for this paper.


Displaying record number 56536

Download this epitope record as JSON.

HXB2 Location Pol(67-76)
Protease(11-20)
DNA(2283..2312)
Pol Epitope Map
Author Location Pol
Epitope VTIKIGGQLK Epitope Alignment
VTIKIGGQLK epitope logo
Epitope Name Pol98
Subtype B
Species (MHC/HLA) human(A3)
Immunogen vaccine
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, polyepitope
Vaccine component other

Notes

References

Wilson2008 Cara C. Wilson, Mark J. Newman, Brian D. Livingston, Samantha MaWhinney, Jeri E. Forster, Jim Scott, Robert T. Schooley, and Constance A. Benson. Clinical Phase 1 Testing of the Safety and Immunogenicity of an Epitope-Based DNA Vaccine in Human Immunodeficiency Virus Type 1-Infected Subjects Receiving Highly Active Antiretroviral Therapy. Clin. Vaccine Immunol., 15(6):986-994, Jun 2008. PubMed ID: 18400976. Show all entries for this paper.


Displaying record number 56516

Download this epitope record as JSON.

HXB2 Location Pol(67-76)
Protease(11-20)
DNA(2283..2312)
Pol Epitope Map
Author Location Pol
Epitope VTIKIGGQLK Epitope Alignment
VTIKIGGQLK epitope logo
Epitope Name Pol98
Subtype B, C, D
Species (MHC/HLA) human, mouse(A3 supertype)
Immunogen HIV-1 infection
Country United States
Experimental methods CD8 T-cell Elispot - IFNγ, Other
Keywords binding affinity, supertype, vaccine-induced immune responses, HLA cross-presentation

Notes

References

Wilson2003 Cara C. Wilson, Denise McKinney, Michelle Anders, Samantha MaWhinney, Jeri Forster, Claire Crimi, Scott Southwood, Alessandro Sette, Robert Chesnut, Mark J Newman, and Brian D Livingston. Development of a DNA Vaccine Designed to Induce Cytotoxic T Lymphocyte Responses to Multiple Conserved Epitopes in HIV-1. J. Immunol., 171(10):5611-5623, 15 Nov 2003. PubMed ID: 14607970. Show all entries for this paper.


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