Search CTL/CD8+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 52859

Download this epitope record as JSON.

HXB2 Location	gp160(89-98) gp120(89-98) DNA(6489..6518)	gp160 Epitope Map
Author Location	Env
Epitope	VTENFNMWKN	Epitope Alignment
Epitope Name	1284
Subtype	multiple
Species (MHC/HLA)	human(A11, A68 supertype)
Immunogen	HIV-1 infection
Patient MHC/HLA	606001: A1, A68, B15, B40, Cw3; 523001: A11, A3, B14, B51, Cw8
Country	United States
Experimental methods	T-cell Elispot
Keywords	binding affinity, supertype, computational epitope prediction, HLA cross-presentation, novel epitope

Notes

• Epitopes defined using sequence parsing and matching algorithm Conservatrix, and epitope prediction tool EpiMatrix, were shown to be conserved in a broad range of HIV-1 sequences derived from different parts of the world. 31 novel highly conserved HIV-1 epitopes were found, among which four were recognized as promiscuous epitopes and five as MHC supertypes.
• Estimated binding probability for VTENFNMWKN:17%. This epitope can be presented by the A11, A68 supertype.

References

DeGroot2003 Anne S. De Groot, Bill Jesdale, William Martin, Caitlin Saint Aubin, Hakima Sbai, Andrew Bosma, Judy Lieberman, Gail Skowron, Fadi Mansourati, and Kenneth H. Mayer. Mapping Cross-Clade HIV-1 Vaccine Epitopes Using a Bioinformatics Approach. Vaccine, 21(27-30):4486-4504, 1 Oct 2003. PubMed ID: 14505932. Show all entries for this paper.