Search CTL/CD8+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 52113

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HXB2 Location	gp160(208-219) gp120(208-219) DNA(6846..6881)	gp160 Epitope Map
Author Location	Env
Epitope	VSFEPIPPHYCA	Epitope Alignment
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Experimental methods
Keywords	epitope processing

Notes

• SP 511 is an A2 restricted CTL clone generated from a Ugandan subject that recognizes VSFEPIPPHYCA.
• CTL could be activated by a fusion protein of an HIV protein and anthrax lethal factor (LFn-HIV) that promotes antigen presenting cell uptake of exogenous protein and allows processing through the MHC class I pathway. This strategy for CTL detection could allow antigen presentation without generation of cells by the standard methods of using live viral vectors carrying a protein, or by loading the cells with peptides and by-passing processing.

References

Cao2002 Huyen Cao, Deepak Agrawal, Nicholas Kushner, Neal Touzjian, Max Essex, and Yichen Lu. Delivery of exogenous protein antigens to major histocompatibility complex class I pathway in cytosol. J. Infect. Dis., 185(2):244-251, 15 Jan 2002. PubMed ID: 11807699. Show all entries for this paper.

Displaying record number 53910

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HXB2 Location	gp160(208-219) gp120(208-219) DNA(6846..6881)	gp160 Epitope Map
Author Location	Env
Epitope	VSFEPIPPHYCA	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A2)
Immunogen	HIV-1 infection
Patient MHC/HLA	A*02:02, A*03:01, B*07:02, B*15:16
Country	United States
Experimental methods
Keywords	escape, acute/early infection

Notes

• Full HIV genomes from nine individuals were analyzed for mutations prior to seroconversion and 7 to 28 days later. It was found that the influence of the host's HLA type was reflected within weeks of infection; a statistically significant number of early nonsynonymous mutations were observed within previously reported CTL epitopes.
• K to E mutation was observed in position 4.

References

Bernardin2005 Flavien Bernardin, Denice Kong, Lorraine Peddada, Lee Ann Baxter-Lowe, and Eric Delwart. Human Immunodeficiency Virus Mutations During the First Month of Infection are Preferentially Found in Known Cytotoxic T-Lymphocyte Epitopes. J. Virol., 79(17):11523-11528, Sep 2005. PubMed ID: 16103205. Show all entries for this paper.