Search CTL/CD8+ T-Cell Epitope Database

Found 3 matching records:

Displaying record number 685

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HXB2 Location	gp160(208-217) gp120(208-217) DNA(6846..6875)	gp160 Epitope Map
Author Location	gp120( subtype B)
Epitope	VSFEPIPIHY	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(A29)
Immunogen	HIV-1 exposed seronegative
Experimental methods
Keywords

Notes

• 11/16 heavily HIV exposed but persistently seronegative sex-workers in Nairobi had HIV-specific CD8 gamma-IFN responses in the cervix -- systemic CD8+ T cell responses tended to be to the same epitopes but at generally lower levels than cervical CD8+ T cell responses.
• Low risk individuals did not have such CD8+ cells.
• CD8+ T cell epitopes: DTVLEDINL (3 individuals), SLYNTVATL (4 individuals), LSPRTLNAW (3 individuals) and YPLTFGWCF (4 individuals) were most commonly recognized by the HIV-resistant women.

References

Kaul2000 R. Kaul, F. A. Plummer, J. Kimani, T. Dong, P. Kiama, T. Rostron, E. Njagi, K. S. MacDonald, J. J. Bwayo, A. J. McMichael, and S. L. Rowland-Jones. HIV-1-Specific Mucosal CD8+ Lymphocyte Responses in the Cervix of HIV-1-Resistant Prostitutes in Nairobi. J. Immunol., 164:1602-1611, 2000. PubMed ID: 10640781. Show all entries for this paper.

Displaying record number 1664

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HXB2 Location	gp160(208-217) gp120(208-217) DNA(6846..6875)	gp160 Epitope Map
Author Location	gp120(263-272)
Epitope	VSFEPIPIHY	Epitope Alignment
Species (MHC/HLA)	human(A29)
Immunogen	HIV-1 exposed seronegative, HIV-1 infection
Experimental methods
Keywords	HIV exposed persistently seronegative (HEPS)

Notes

• ELISPOT was used to study CTL responses to a panel of 54 predefined HIV-1 epitopes in 91 HIV-1-exposed, persistently seronegative (HEPS) and 87 HIV-1-infected female Nairobi sex workers.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.

Displaying record number 52729

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HXB2 Location	gp160(208-217) gp120(208-217) DNA(6846..6875)	gp160 Epitope Map
Author Location	gp120
Epitope	VSFEPIPIHY	Epitope Alignment
Species (MHC/HLA)	human(A29)
Immunogen	HIV-1 infection
Experimental methods	Intracellular cytokine staining
Keywords	immunodominance, genital and mucosal immunity

Notes

• Predefined immunodominant peptide responses were used to compare CD8+ T cells responses in the blood and cervix of 16 HIV+ Kenyan sex workers. Cervical responses were detected in 8/10 women from whom adequate samples could be obtained. The frequency of the CD8+ T cell response in the genital tract was comparable to the blood, with a trend toward being slightly higher.
• The immunodominant response was to this epitope in the PBMC of 1/16 patients (Kaul et al. 2001, AIDS, 107:1303).

References

Kaul2003 Rupert Kaul, Paul Thottingal, Joshua Kimani, Peter Kiama, Charles W. Waigwa, Job J. Bwayo, Francis A. Plummer, and Sarah L. Rowland-Jones. Quantitative Ex Vivo Analysis of Functional Virus-Specific CD8 T Lymphocytes in the Blood and Genital Tract of HIV-Infected Women. AIDS, 17(8):1139-1144, May 2003. PubMed ID: 12819514. Show all entries for this paper.