Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 60396

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	Env(42-51)
Epitope	`VPVWKEATTT`	Epitope Alignment
Epitope Name	VT10
Species (MHC/HLA)	human(A*6802)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
VPVWKEATTT had a significantly positive association with HLA A*6802; it was recognized by 4/19 A*6802-positive subjects and 8/249 A*6802-negative subjects.

References

Pereyra2014 Florencia Pereyra, David Heckerman, Jonathan M. Carlson, Carl Kadie, Damien Z. Soghoian, Daniel Karel, Ariel Goldenthal, Oliver B. Davis, Charles E. DeZiel, Tienho Lin, Jian Peng, Alicja Piechocka, Mary Carrington, and Bruce D. Walker. HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes. J. Virol., 88(22):12937-12948, Nov 2014. PubMed ID: 25165115. Show all entries for this paper.

Displaying record number 60397

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	Env(42-51)
Epitope	`VPVWKEATTT`	Epitope Alignment
Epitope Name	VT10
Species (MHC/HLA)	human(B3502, B3503, B*5301)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
VPVWKEATTT had a significantly positive association with HLA B*3502,B*3503,B*5301; it was recognized by 6/36 B*3502,B*3503,B*5301-positive subjects and 12/268 B*3502,B*3503,B*5301-negative subjects.

References

Displaying record number 60394

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	Env(42-51)
Epitope	`VPVWKEATTT`	Epitope Alignment
Epitope Name	VT10
Species (MHC/HLA)	human(B*39)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
VPVWKEATTT had a significantly positive association with HLA B*39; it was recognized by 11/27 B*39-positive subjects and 18/304 B*39-negative subjects.

References

Displaying record number 638

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	gp120(42-51 PV22)
Epitope	`VPVWKEATTT`	Epitope Alignment
Species (MHC/HLA)	human(B55)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

P. Johnson, unpublished.

References

Brander1995a Christian Brander and Bruce Walker. The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. In The HLA-Class I Restricted CTL Response in HIV-1 Infection: Identification of Optimal Epitopes. pages IV--1--IV--9. Los Alamos National Laboratory, Theoretical Biology and Biophysics, Los Alamos, New Mexico, 1995. URL: http://hiv-web.lanl.gov/immunology. Show all entries for this paper.

Displaying record number 1435

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	gp120(41-55)
Epitope	`VPVWKEATTT`	Epitope Alignment
Species (MHC/HLA)	human(B55)
Immunogen	HIV-1 infection
Experimental methods
Keywords

Notes

One of the 51 HIV-1 epitopes selected by Ferrari et al. as good candidate CTL epitopes for vaccines by virtue of being conserved and presented by common HLA alleles.

References

Ferrari2000 G. Ferrari, D. D. Kostyu, J. Cox, D. V. Dawson, J. Flores, K. J. Weinhold, and S. Osmanov. Identification of highly conserved and broadly cross-reactive HIV type 1 cytotoxic T lymphocyte epitopes as candidate immunogens for inclusion in Mycobacterium bovis BCG-vectored HIV vaccines. AIDS Res. Hum. Retroviruses, 16(14):1433-43, 20 Sep 2000. PubMed ID: 11018863. Show all entries for this paper.

Displaying record number 58220

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	gp120( LAI)
Epitope	`VPVWKEATTT`	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B55)
Immunogen	HIV-1 infection
Experimental methods	Chromium-release assay
Keywords	immunodominance

Notes

Epitopes were identified in 3 conserved regions of gp160. CTL from 5/20 sujects recognized 3 overlapping immunodominant epitopes.
1/20 subjects recognized VPVWKEATTT in the context of HLA-B55.

References

Shankar1996 P. Shankar, J. A. Fabry, D. M. Fong, and J. Lieberman. Three Regions of HIV-1 gp160 Contain Clusters of Immunodominant CTL Epitopes. Immunol. Lett., 52:23-30, 1996. PubMed ID: 8877415. Show all entries for this paper.

Displaying record number 55127

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	gp120(42-51)
Epitope	`VPVWKEATTT`	Epitope Alignment
		Show epitope variants
Species (MHC/HLA)	human(B*5501, B55)
Immunogen
Experimental methods
Keywords	subtype comparisons, viral fitness and reversion

Notes

Determined the frequencies of known CD8+ and CD4+ Env epitope sequences among Brazilian HIV sequences of various subtypes.
Present in 32/51 Brazilian HIV sequences; variant VPVWKEAkTT present in all Brazilian subtype C sequences.

References

Queiroz2007 Artur Trancoso Lopo de Queiroz, Luciane Amorim Santos, Domingos Ramon Moreau, Tulio de Oliveira, David I. Watkins, Bernardo Galvão-Castro, and Luiz Carlos Junior Alcantara. Identification and Characterization of Previously Described Epitopes in HIV-1 Subtypes B, C, F and BF in Brazil. Braz. J. Infect. Dis., 11(1):27-30, Feb 2007. PubMed ID: 17625722. Show all entries for this paper.

Displaying record number 639

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	gp120(42-51 PV22)
Epitope	`VPVWKEATTT`	Epitope Alignment
Species (MHC/HLA)	human(B*5501)
Immunogen	HIV-1 infection
Experimental methods
Keywords	optimal epitope

Notes

C. Brander notes this is a B*5501 epitope.

References

Llano2019 Anuska Llano, Samandhy Cedeño, Sandra Silva Arrieta, and Christian Brander. The 2019 Optimal HIV CTL Epitopes Update: Growing Diversity in Epitope Length and HLA restriction. 2019. Show all entries for this paper.

Displaying record number 60395

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	Env(42-51)
Epitope	`VPVWKEATTT`	Epitope Alignment
Epitope Name	VT10
Species (MHC/HLA)	human(B*81)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
VPVWKEATTT had a significantly positive association with HLA B*81; it was recognized by 7/10 B*81-positive subjects and 29/331 B*81-negative subjects.

References

Displaying record number 60398

HXB2 Location	gp160(42-51) gp120(42-51) DNA(6348..6377)	gp160 Epitope Map
Author Location	Env(42-51)
Epitope	`VPVWKEATTT`	Epitope Alignment
Epitope Name	VT10
Species (MHC/HLA)	human(C*01)
Immunogen	HIV-1 infection
Experimental methods	CD8 T-cell Elispot - IFNγ, Flow cytometric T-cell cytokine assay
Keywords	rate of progression, optimal epitope

Notes

Correlation between HLA class I and spontaneous control of HIV-1 was significant for 7-8 epitopes when 341 chronic, HIV-infected subjects, divided into controllers and non-controllers, were tested for EliSpot responses to 257 optimally defined epitopes. 21 epitopes were associated with viral progression. Protective epitopes tend to cluster in regions of critical stability for the protein, therefore constraining escape.
VPVWKEATTT had a significantly positive association with HLA C*01; it was recognized by 3/26 C*01-positive subjects and 5/223 C*01-negative subjects.