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Displaying record number 55531

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HXB2 Location	Nef(146-156) DNA(9232..9264)	Nef Epitope Map
Author Location	Nef(150-160)
Epitope	VPVEPEKVEEA	Epitope Alignment
Subtype	B
Species (MHC/HLA)	human(B*54:01)
Immunogen	HIV-1 infection
Country	Japan
Experimental methods	Chromium-release assay, Intracellular cytokine staining
Keywords	optimal epitope

Notes

• Asian-expressed HLA-B*5401-restricted epitopes were identified using overlapping-peptide methods and characterized. 5 epitopes from Pol and Nef induced CTL responses that killed target cells in more than 25% of B*5401-carrying tested patients.
• 7 peptides from Pol and Nef are listed in Fig. 2 as candidates for B*5401 restriction. No Gag-specific epitopes were identified in this study from the patient whose lymphocytes were screened.
• VPVEPEKVEEA was defined as optimal epitope for HLA-B*5401 restriction, using truncated peptides.

References

Kitano2008 Mitsutaka Kitano, Naoki Kobayashi, Yuka Kawashima, Tomohiro Akahoshi, Kiyoshi Nokihara, Shinichi Oka, and Masafumi Takighuchi. Identification and Characterization of HLA-B*5401-Restricted HIV-1-Nef and Pol-Specific CTL Epitopes. Microbes Infect, 10(7):7647-72, Jun 2008. PubMed ID: 18538615. Show all entries for this paper.