HIV molecular immunology database

 

Search CTL/CD8+ T-Cell Epitope Database

Found 10 matching records:

Displaying record number 57318

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Subtype A, CRF02_AG, CRF06_cpx, CRF09_cpx
Species (MHC/HLA) human(B*35)
Immunogen HIV-1 infection
Country Burkina Faso
Experimental methods Other
Keywords drug resistance

Notes

References

Tebit2009 Denis M. Tebit, Lassana Sangaré, Fabrice Tiba, Yameogo Saydou, Aline Makamtse, Hermann Somlare, Guillaume Bado, Boris G. Kouldiaty, Inoussa Zabsonre, Sibiri L. Yameogo, Kanokporn Sathiandee, Joseph Y. Drabo, and Hans-Georg Kräusslich. Analysis of the Diversity of the HIV-1 pol Gene and Drug Resistance Associated Changes among Drug-Naïve Patients in Burkina Faso. J. Med. Virol., 81(10):1691-701, Oct 2009. PubMed ID: 19697403. Show all entries for this paper.


Displaying record number 430

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location ( SF2)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Show epitope variants
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Experimental methods  
Keywords binding affinity, rate of progression, escape

Notes

References

Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.


Displaying record number 57337

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Epitope Name Pol273
Subtype B
Species (MHC/HLA) human(B35)
Immunogen HIV-1 infection
Country Japan
Experimental methods Chromium-release assay, Cytotoxicity assay, Intracellular cytokine staining, Proliferation, Tetramer binding
Keywords binding affinity

Notes

References

Ueno2007 Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-Specific CTLs. J. Immunol., 178(9):5513-5523, 1 May 2007. PubMed ID: 17442933. Show all entries for this paper.


Displaying record number 61888

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Epitope Name VY10, RTVY10
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, CTL suppression of replication, Intracellular cytokine staining, Tetramer binding
Keywords escape, HLA associated polymorphism

Notes

References

Murakoshi2018a Hayato Murakoshi, Madoka Koyanagi, Tomohiro Akahoshi, Takayuki Chikata, Nozomi Kuse, Hiroyuki Gatanaga, Sarah L. Rowland-Jones, Shinichi Oka, and Masafumi Takiguchi. Impact of a Single HLA-A*24:02-Associated Escape Mutation on the Detrimental Effect of HLA-B*35:01 in HIV-1 Control. EBioMedicine, 36:103-112, Oct 2018. PubMed ID: 30249546. Show all entries for this paper.


Displaying record number 1341

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords  

Notes

References

Tomiyama2000a H. Tomiyama, S. Oka, G. S. Ogg, S. Ida, A. J. McMichael, and M. Takiguchi. Expansion of HIV-1-specific CD28- CD45RA- CD8+ T cells in chronically HIV-1-infected individuals. AIDS, 14(13):2049-51, 8 Sep 2000. PubMed ID: 10997412. Show all entries for this paper.


Displaying record number 55575

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Country Japan
Experimental methods CTL suppression of replication, Cytokine production, HLA binding, Other, Tetramer binding
Keywords class I down-regulation by Nef

Notes

References

Ueno2008 Takamasa Ueno, Chihiro Motozono, Sachi Dohki, Philip Mwimanzi, Susanne Rauch, Oliver T. Fackler, Shinichi Oka, and Masafumi Takiguchi. CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef. J. Immunol., 180(2):1107-1116, 15 Jan 2008. PubMed ID: 18178851. Show all entries for this paper.


Displaying record number 429

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT(273-282 SF2)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Show epitope variants
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Experimental methods  
Keywords review

Notes

References

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.

Tomiyama1997 H. Tomiyama, K. Miwa, H. Shiga, Y. I. Moore, S. Oka, A. Iwamoto, Y. Kaneko, and M. Takiguchi. Evidence of Presentation of Multiple HIV-1 Cytotoxic T Lymphocyte Epitopes by HLA-B*3501 Molecules That Are Associated with the Accelerated Progression of AIDS. J. Immunol., 158:5026-5034, 1997. PubMed ID: 9144523. Show all entries for this paper.


Displaying record number 58654

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location Pol(273-282)
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Epitope Name RT VY10
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection
Country Barbados, Botswana, Haiti, Japan, Mexico, South Africa, United Kingdom, United States
Experimental methods CD8 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining, Tetramer binding
Keywords optimal epitope, novel epitope

Notes

References

Matthews2012 Philippa C. Matthews, Madoka Koyanagi, Henrik N. Kløverpris, Mikkel Harndahl, Anette Stryhn, Tomohiro Akahoshi, Hiroyuki Gatanaga, Shinichi Oka, Claudia Juarez Molina, Humberto Valenzuela Ponce, Santiago Avila Rios, David Cole, Jonathan Carlson, Rebecca P. Payne, Anthony Ogwu, Alfred Bere, Thumbi Ndung'u, Kamini Gounder, Fabian Chen, Lynn Riddell, Graz Luzzi, Roger Shapiro, Christian Brander, Bruce Walker, Andrew K. Sewell, Gustavo Reyes Teran, David Heckerman, Eric Hunter, Søren Buus, Masafumi Takiguchi, and Philip J. R. Goulder. Differential Clade-Specific HLA-B*3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope. J. Virol., 86(23):12643-12654, Dec 2012. PubMed ID: 22973023. Show all entries for this paper.


Displaying record number 61868

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HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location  
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Epitope Name VY10
Subtype B
Species (MHC/HLA) human(B*35:01)
Immunogen HIV-1 infection, vaccine
Country Japan
Experimental methods CD8 T-cell Elispot - IFNγ, Intracellular cytokine staining, Other
Keywords vaccine-induced immune responses

Notes

References

Zou2019 Chengcheng Zou, Hayato Murakoshi, Nozomi Kuse, Tomohiro Akahoshi, Takayuki Chikata, Hiroyuki Gatanaga, Shinichi Oka, Tomáš Hanke, and Masafumi Takiguchi. Effective Suppression of HIV-1 Replication by Cytotoxic T Lymphocytes Specific for Pol Epitopes in Conserved Mosaic Vaccine Immunogens. J. Virol., 93(7), 1 Apr 2019. PubMed ID: 30674626. Show all entries for this paper.


Displaying record number 56015

Download this epitope record as JSON.

HXB2 Location Pol(273-282)
RT(118-127)
DNA(2901..2930)
Pol Epitope Map
Author Location RT
Epitope VPLDKDFRKY Epitope Alignment
VPLDKDFRKY epitope logo
Show epitope variants
Epitope Name VY10(RT)
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country China
Experimental methods CD8 T-cell Elispot - IFNγ
Keywords variant cross-reactivity, chronic infection

Notes

References

Zhai2008 Song Zhai, Yan Zhuang, Yang Song, Shu Li, Dedong Huang, Wenzhen Kang, Xinhong Li, Qi Liao, Yanhou Liu, Zhongfang Zhao, Yichen Lu, and Yongtao Sun. HIV-1-Specific Cytotoxic T Lymphocyte (CTL) Responses Against Immunodominant Optimal Epitopes Slow the Progression of AIDS in China. Curr. HIV Res., 6(4):335-350, Jun 2008. PubMed ID: 18691032. Show all entries for this paper.


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